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20,252 grants found
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T Cell-Specific BRCA1 Function in Antitumor Immunity and Immunotherapy
ABSTRACT Women with germline mutations of BRCA1 have about an 80% lifetime risk of developing breast cancer. All somatic cells in a germline BRCA1 mutation carrier harbor the same...
Therapeutic targeting of the SWI/SNF chromatin remodeler to regulate GBM chemosensitivity
Glioblastoma (GBM) is the most common primary malignancy of the adult brain and is among the most devastating cancers as it is invariably lethal. The perivascular niche and necroti...
Exploring microRNA degradation in T-cell acute lymphoblastic leukemia
PROJECT SUMMARY Gene expression, the flow of genetic information from DNA to messenger RNA (mRNA) to protein, involves delicate regulation by a group of small RNAs named microRNAs....
Stromal and vascular inputs into pancreatic cancer tumor neighborhoods
PROJECT SUMMARY Cancer cells are the organizers of their surroundings and create a tumor microenvironment (TME) favoring cell division even when oxygen and nutrients are limiting....
Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer.
PROJECT SUMMARY/ABSTRACT Lung cancer remains the leading cause of cancer-related deaths in the U.S. and worldwide. Non–small cell lung cancer (NSCLC) accounts for approximately 85%...
Stromal and vascular inputs into pancreatic cancer tumor neighborhoods
PROJECT SUMMARY Cancer cells are the organizers of their surroundings and create a tumor microenvironment (TME) favoring cell division even when oxygen and nutrients are limiting....
Effect of maternal obesity on breast cancer among offspring: role of the gut microbiota
In Minnesota, American Indian (34.1%) and non-Hispanic Black (33.4%) women are over twice as likely to be obese during pregnancy than non-Hispanic White women of whom 16.6% are obe...
Targeting the long isoform of the prolactin receptor to treat autoimmune diseases and B-cell malignancies
PROJECT SUMMARY Early interventions for high-risk B-cell malignancies, including diffuse large B cell lymphoma (DLBCL), Burkitt's Lymphoma (BL), and B-cell acute lymphoblastic...
Obscurin-Deficient Breast Epithelia Generate Secreted Factors that Prime Lung Vascular Smooth Muscle Cell Pre-metastatic Microenvironment Formation
Project Summary/Abstract: New therapies blocking metastatic spread are greatly needed to improve breast cancer patient survival. Pre-metastatic niche development has been identifie...
Evaluating unique aspects of quiescent ovarian cancer cell biology for therapeutic targets
Most ovarian cancer (OvCa) patients develop fatal chemotherapy-resistant disease. Elucidating mechanisms of chemoresistance in OvCa may identify therapeutic targets to prevent or t...
Novel ultra-short cell free DNA biomarkers for early detection of non-small cell lung cancer.
PROJECT SUMMARY/ABSTRACT Lung cancer remains the leading cause of cancer-related deaths in the U.S. and worldwide. Non–small cell lung cancer (NSCLC) accounts for approximately 85%...
Evaluating unique aspects of quiescent ovarian cancer cell biology for therapeutic targets
Most ovarian cancer (OvCa) patients develop fatal chemotherapy-resistant disease. Elucidating mechanisms of chemoresistance in OvCa may identify therapeutic targets to prevent or t...
T Cell-Specific BRCA1 Function in Antitumor Immunity and Immunotherapy
ABSTRACT Women with germline mutations of BRCA1 have about an 80% lifetime risk of developing breast cancer. All somatic cells in a germline BRCA1 mutation carrier harbor the same...
Targeting the long isoform of the prolactin receptor to treat autoimmune diseases and B-cell malignancies
PROJECT SUMMARY Early interventions for high-risk B-cell malignancies, including diffuse large B cell lymphoma (DLBCL), Burkitt's Lymphoma (BL), and B-cell acute lymphoblastic...
Therapeutic targeting of the SWI/SNF chromatin remodeler to regulate GBM chemosensitivity
Glioblastoma (GBM) is the most common primary malignancy of the adult brain and is among the most devastating cancers as it is invariably lethal. The perivascular niche and necroti...
Effect of maternal obesity on breast cancer among offspring: role of the gut microbiota
In Minnesota, American Indian (34.1%) and non-Hispanic Black (33.4%) women are over twice as likely to be obese during pregnancy than non-Hispanic White women of whom 16.6% are obe...
Stromal and vascular inputs into pancreatic cancer tumor neighborhoods
PROJECT SUMMARY Cancer cells are the organizers of their surroundings and create a tumor microenvironment (TME) favoring cell division even when oxygen and nutrients are limiting....
Obscurin-Deficient Breast Epithelia Generate Secreted Factors that Prime Lung Vascular Smooth Muscle Cell Pre-metastatic Microenvironment Formation
Project Summary/Abstract: New therapies blocking metastatic spread are greatly needed to improve breast cancer patient survival. Pre-metastatic niche development has been identifie...
Tumor and immune determinants of effective anti-tumor immunity in renal cell carcinoma
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) targeting the PD-1 pathway have transformed the management of many advanced cancers, including renal cell carcinoma (RCC), but m...
Elucidating the relevance of BARD1-PLK1 interaction in PDAC and response to therapy
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. The overall 5-year survival rate is only 11% and there is an unmet need for...