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20,252 grants found
Showing 3,981 – 4,000 of 20,252 grants
Admin Core
Summary The primary goal of the Administrative Core is to provide logistical, organizational, and managerial support for this Biomarker Characterization Center (BCC) and foster the...
Understanding Breast Cancer Risk and Screening in Transgender Persons through a Pilot Breast Cancer Screening Program
PROJECT SUMMARY/ABSTRACT In the U.S., an estimated 1.4 million people identify as transgender (TG), defined as a person whose gender is different than their sex assigned at birth,...
BCC for Prostate Cancer: Discovery and Translation of Biomarkers for Clinical Unmet Needs
Active surveillance (AS) is the preferred management option for low risk prostate cancer (PCa) patients who would benefit from conservative treatment. However, due to the lack of r...
Admin Core
Summary The primary goal of the Administrative Core is to provide logistical, organizational, and managerial support for this Biomarker Characterization Center (BCC) and foster the...
Biomarker Development Laboratory
Active surveillance (AS), which holds off on treatment for low-risk PCa patients until signs of progression are detected through careful monitoring, was developed as a potential so...
Biomarker Reference Laboratory
Our proposed EDRN BRL, which is located within the Clinical Chemistry Division (CCD) of the Johns Hopkins Medical Institutions, will be an integral part of the BCC. The BRL will co...
The Role of IL-15 in Cutaneous T-cell Lymphoma Progression
PROJECT SUMMARY Cutaneous T-cell Lymphoma (CTCL) is an incurable disease characterized by the localization of neoplastic T lymphocytes to the skin. Patients display a progressive d...
A Novel Framework for Sensitive and Reliable Early Diagnosis, Topographic Mapping, and Stiffness Classification of Colorectal Cancer Polyps
Summary/Abstract: Our long-term goal is to develop a novel soft robotic endoscope with intelligent tactile sensing balloons and complementary machine learning (ML) and computer vis...
Biomarker Development Laboratory
Active surveillance (AS), which holds off on treatment for low-risk PCa patients until signs of progression are detected through careful monitoring, was developed as a potential so...
Biomarker Reference Laboratory
Our proposed EDRN BRL, which is located within the Clinical Chemistry Division (CCD) of the Johns Hopkins Medical Institutions, will be an integral part of the BCC. The BRL will co...
The Role of IL-15 in Cutaneous T-cell Lymphoma Progression
PROJECT SUMMARY Cutaneous T-cell Lymphoma (CTCL) is an incurable disease characterized by the localization of neoplastic T lymphocytes to the skin. Patients display a progressive d...
Understanding Breast Cancer Risk and Screening in Transgender Persons through a Pilot Breast Cancer Screening Program
PROJECT SUMMARY/ABSTRACT In the U.S., an estimated 1.4 million people identify as transgender (TG), defined as a person whose gender is different than their sex assigned at birth,...
A Novel Framework for Sensitive and Reliable Early Diagnosis, Topographic Mapping, and Stiffness Classification of Colorectal Cancer Polyps
Summary/Abstract: Our long-term goal is to develop a novel soft robotic endoscope with intelligent tactile sensing balloons and complementary machine learning (ML) and computer vis...
Targeting GSK3B in refractory B-cell malignancies
Abstract GSK3E functions as essential negative regulator of E-catenin, while E-catenin accumulation represents a central oncogenic driver in cancer. In solid tumors, E-catenin form...
Analyzing Patient-Level Data in a Breast Cancer Clinical Trial
ABSTRACT Most women treated for breast cancer will experience some form of drug-related toxicity and subsequent impairments in Health-related Quality of Life (HRQOL), yet toxicity...
Research Project 2 Proteogenomic-guided therapeutic targeting of breast cancer patient-derived xenograft metastases
Project Summary/Abstract Breast cancer is diagnosed in 1-of-8 women and is the most common type of cancer diagnosed at VCU. There are several genetically distinct subtypes of human...
Myeloid cell-selective, oligonucleotide-based STAT3 inhibition combined with total marrow and lymphoid irradiation for immunotherapy of acute myeloid leukemia
PROJECT SUMMARY There has been little or no long-term improvement in outcomes for patients with treatment-refractory acute myeloid leukemia (AML). The recently developed image-guid...
Noninvasive monitoring of therapeutic response to immune checkpoint inhibitors using circulating exosomes in non-small cell lung cancer
Summary/ Abstract: The emergence of immune checkpoint blockade (ICB) therapy has revolutionized the treatment for advanced cancers including lung cancer. Particularly, anti-PD-1/PD...
United for Health Equity - Living PDX Program (U4HELPP)
PROJECT SUMMARY/ABSTRACT – OVERALL The United for Health Equity-Living PDX Program (U4HELPP) seeks to develop >500 new patient-derived xenograft (PDX) models of cancers originat...
Bioinformatics Core
Project Summary/Abstract The primary goal of the Bioinformatics Core of VCU’s U4HELPP is to provide data management, quality control, reproducible analyses, data storage, and data...