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20,252 grants found
Showing 381 – 400 of 20,252 grants
Integrative Deep Learning Models for Multimodal Markers of Cancer Treatment Outcomes
PROJECT SUMMARY The most pressing challenge in oncology is the need for accurate biomarker-driven prognostic/predictive risk- stratification to identify patients who are unlikely t...
Discovery of Novel Therapeutic Strategies for Cancer Immunotherapy
Project Summary The central hypothesis of my F99-phase proposal is that the lack of T-cell infiltration into human tumors may be caused by the presence of tumor-derived T-cell excl...
IMAT-ITCR Collaboration: Multiplexed Spatial Data Calibration and analysis using micro-capsules
Project summary A major goal of cancer research is to define the composition of the tumor micro-environment (TME) across individuals. Once measured, differences in TME composition...
IMAT-ITCR Collaboration: Engineering model-based systems to monitor and steer subclonal dynamics
PROJECT SUMMARY Ongoing cancer genomic studies have documented numerous mutations across all tumor types. Most cancer mutations have not been functionally characterized, as conduct...
Comprehensive Cancer Center Support Grant
Cervical cancer elimination as a public health problem has become a reality if we focus on the uptake of three evidence-based tools: HPV vaccination, cervical cancer screening, and...
Mayo CCCG (Supp) - Impact of Multi-Channel Communication Campaigns on Cancer Prevention, Control and Survivorship (CaPCaS) in Black, Hispanic, Rural, and Sexual and Gender Minority Populations
ABSTRACT This application is being submitted by the Mayo Clinic Comprehensive Cancer Center (MCCCC) to extend the period of support for the P30 Administrative Supplement for Multi-...
Communication in American Indians thru Strategies for Equity 4 Cancer (CASE4Cancer)
PROJECT SUMMARY: Cancer continues to be the top cause of death for American Indians (AIs) in North Carolina. With higher rates of colorectal cancer (CRC) late stage diagnosis and m...
TAZ-driven Regulation of Tumor Microenvironment in Triple-Negative Breast Cancer
ABSTRACT Breast cancer (BC) is a complex and heterogeneous neoplastic disease with a high incidence and mortality. BC can be divided into clinical, histopathologic, and molecular s...
P30 Administrative Supplement for Multi-Channel Communication Campaigns for Improvements in Cancer Education and Outcomes (MICEO) in Underserved Populations
PROJECT ABSTRACT Childhood cancer survivors are a high-priority, underserved population for HPV vaccination. They are less likely to be vaccinated when compared to the general popu...
Multi-antigen-specific CAR T cells to treat acute myeloid leukemia
PROJECT SUMMARY Chimeric antigen receptor (CAR) T cell therapy is a novel form of cellular immunotherapy in which the antigen specificity of T cells is redirected using synthetic r...
Discerning mechanisms of semaphorin 7A-mediated tumor progression via immunoevasion
Project We Summary/Abstract have identified that semaphorin 7a (SEMA7A)—a signaling molecule that activates integrin-β1 signaling in cancer—is upregulated in postpartum breast canc...
Federated Learning Framework for Multimodal Survival Analysis in Pediatric Cancers
Overall Summary/Abstract Childhood cancers, although rare, significantly impact thousands of children globally each year. The complexity and variability of these cancers necessitat...
SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use
Abstract Serologic testing for presence of SARS-CoV-2 antibodies is a critical tool for understanding the epidemiology and designing control strategies for the COVID-19 pandemic. O...
Tulane University COVID Antibody and Immunity Network (TUCAIN) Supplement
ABSTRACT The SARS-CoV-2 virus, the causative agent of COVID-19, has infected a reported 13,810,247 persons globally as of July 16, 2020 with a mortality rate of 4.2%. In the State...
A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research
PROJECT SUMMARY / ABSRACT CIBMTR (Center for International Blood and Marrow Transplant Research) represents an international network of >360 treatment centers and maintains a cl...
Targeting regenerative reprogramming in colorectal cancer
ABSTRACT Poorly defined fitness features enable a subset of cancer cells to survive therapy, ultimately giving rise to treatment-refractory tumors. The expanded use of sequencing t...
Chromatin and immune regulation of tumor growth and progression
PROJECT SUMMARY Lung and pancreatic ductal adenocarcinomas are often diagnosed at very late stages of tumor progression when they are most aggressive and difficult to treat. Curren...
Targeting Oxidized PTP1B for Anticancer Drug Discovery
PROJECT SUMMARY PTP1B, a non-receptor–type oncogenic PTP, also known as PTPN1, is involved in growth factor signaling. The PTP1B gene is frequently amplified in cancers and correla...
Cancer Center Administration
Project Summary/Abstract: Administration Norris Cotton Cancer Center (NCCC) Administration bridges the Geisel School of Medicine at Dartmouth College (Geisel) and Dartmouth-Hitchco...
Cancer Research Career Enhancement
Project Summary/Abstract: Career Enhancement Norris Cotton Cancer Center (NCCC) is a central provider and resource of Career Enhancement activities for its trainees, Program Member...