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20,252 grants found
Showing 21 – 40 of 20,252 grants
Multicomponent mhealth interventions for healthcare providers and the community to increase cancer screening in India
PROJECT SUMMARY/ABSTRACT Given that a large proportion of cancers are detected at a late stage in India, approaches to increase screening uptake could have a significant impact on...
ConnectedNest: a digital platform connecting individuals with cancer to social care
SUMMARY ConnectedNest, a novel electronic social care referral platform developed by XanthosHealth, addresses the impact of social determinants of health (SDoH) on individuals faci...
1/2 Howard - Hopkins Comprehensive Alliance in Cancer Research, Education, and Equity (H2CAREE)
PROJECT SUMMARY In response to NIH PAR-23-308, the Howard-Johns Hopkins Comprehensive Alliance in Cancer Research, Education and Equity (H2CAREE) initiative aims to advance cancer...
2/2 Howard - Hopkins Comprehensive Alliance in Cancer Research, Education, and Equity (H2CAREE)
PROJECT SUMMARY In response to NIH PAR-23-308, the Howard-Johns Hopkins Comprehensive Alliance in Cancer Research, Education and Equity (H2CAREE) initiative aims to advance cancer...
Randomized Clinical Trial of a Culturally-Tailored Suite of Smoking Cessation Resources for American Indian Persons
While American Indian (AI) persons have historically used wild or homegrown tobacco for spiritual purposes, the use of commercially produced tobacco has risen dramatically. Today,...
Development of three KSHV vaccine platforms and chimeric MHV68-K-G for in vivo mouse infection study
Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is a prevalent virus that establishes a lifelong persistent infection in humans and is associated with Kaposi's sa...
NP855 for Targeting Thyrointegrin αvβ3 receptors and Norepinephrine Transporter in Neuroblastoma Management
SUMMARY: Neuroblastoma (NB) is the most common cancer diagnosed in children younger than one year old and is the most frequent solid tumor in children < 5-years of age. Those wi...
Development of a novel, RNA-interference-based therapeutic to treat prostate cancer
PROJECT SUMMARY Prostate cancer (PC) is the most common cancer in men, and the second leading cause of cancer death among men in the United States. There is a critical unmet need t...
Development of a Novel Nectin Targeting Antibody-drug Conjugate for Ovarian Cancer Therapy
PROJECT SUMMARY/ABSTRACT Ovarian cancer is the most lethal gynecologic cancer with limited therapeutic options. Targeted cancer therapeutics, such as antibody-drug conjugates (ADCs...
Bioactivity of CAR T cells secreting T cell engager-anitbodies in humans with glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is a deadly brain tumor with limited treatment options. We have developed a promising new treatment for GBM using chimeric antigen receptor (CAR)...
Video Inspired Discussions about Ethical Outcomes in Pediatrics (VIDEO-PEDS)
Parents of children with cancer often face complicated decision making throughout their child’s illness. Goals-of-care (GOC) interventions help patients, their families, and clinic...
Pediatric acute lymphoblastic leukemia: Improving outcomes through incorporation of novel targeted therapies into treatment for relapsed and newly diagnosed disease
O’Brien R50 Research Specialist (Clinician Scientist) Project Summary/Abstract While many children with acute lymphoblastic leukemia (ALL) are cured with frontline therapy, for tho...
MetaboCore: Needle biopsy assay of drug sensitivity for solid tumors.
Abstract The goal of personalized oncology is to select the most appropriate drug(s) for individual cancers. A number of platforms (e.g., organoids and PDX mice) have been develope...
Torch Recon: An Innovative Reconstruction Software for Increased Throughput and Improved Low-Count Quantitative SPECT Imaging
PROJECT SUMMARY/ABSTRACT Single-photon emission computed tomography (SPECT) imaging plays a pivotal role in radiopharmaceutical therapy (RPT), allowing clinicians to personalize pr...
Steering the next generation of NCI-sponsored clinical trials in gastroesophageal cancers
Gastrointestinal cancers, and gastroesophageal adenocarcinomas in particular, are experiencing a clinical renaissance with the approval of recent biomarker-directed therapies. With...
Assay Development and Prognostic Model for Predicting Early Clinical Failure in Follicular Lymphoma
ABSTRACT Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma (NHL) subtype with a highly variable clinical course. While asymptomatic and low-tumor burden pat...
Multimodal dendrimer theranostics targeting aggressive subtypes of prostate cancer
PROJECT SUMMARY Our ultimate goal is to develop a practical, theranostic platform for managing PC. Prostate cancer (PC) is the second most common cancer and the fifth most frequent...
State-transition and leukemia potential dynamics to inform disease evolution and adaptive therapy
PROJECT SUMMARY Acute myeloid leukemia (AML) is a group of aggressive and highly heterogeneous malignancies with poor overall survival. Despite advances in identification of molecu...
Impact of Rural Hospital Closures on Cancer Outcomes and Cancer Racial Disparity among Medicare Beneficiaries
PROJECT SUMMARY/ABSTRACT Since 2005, 199 rural hospitals have closed in the US. These closures have resulted in a loss of primary care physicians, surgical services, limited access...
Understanding the biology of disparity-associated genomically stable gastric tumors
PROJECT SUMMARY Gastric cancer (GC) has a high mortality rate in Latinos. This is likely the result of multi-level social determinants of health and population-specific factors. Ou...