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20,252 grants found
Showing 3,961 – 3,980 of 20,252 grants
Evaluation of a therapeutic vaccination strategy with motif neoepitope peptide-pulsed autologous dendritic cells for non-small cell lung cancer patients harboring a charged HLA-B binding pocket.
PROJECT SUMMARY Lung cancer is the leading cause of cancer related deaths in the United States and the World. Inefficient prediction of functional tumor neoantigens and insufficien...
Targeting metabolic vulnerabilities induced by the 1p19q codeletion in oligodendrogliomas
PROJECT SUMMARY Gliomas are the most common malignant primary brain tumors in adults. Among gliomas driven by mutant isocitrate dehydrogenase, tumors harboring a 1p/19q codeletion...
Interventional method development for multiplexed personalized drug evaluation using implantable microdevices
Abstract: Novel implantable miniaturized devices (IMDs) placed directly in patient tumors can rapidly evaluate multi-drug responses in-situ. They can be used in any solid tumor to...
Novel therapeutics for the targeted eradication of DDR-defective tumors
PROJECT SUMMARY/ABSTRACT. O6-Methylguanine methyltransferase (MGMT) reverts O6-alkylguanosine residues to guanosine via dealkylation by SN2 displacement. MGMT is ubiquitously expre...
Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment
ABSTRACT The psychosocial care of patients with advanced lung cancer (ALC) has not kept pace with current medical treatments, creating significant gaps in care. Treatments like imm...
Targeting metabolic vulnerabilities induced by the 1p19q codeletion in oligodendrogliomas
PROJECT SUMMARY Gliomas are the most common malignant primary brain tumors in adults. Among gliomas driven by mutant isocitrate dehydrogenase, tumors harboring a 1p/19q codeletion...
Dual-payload antibody-drug conjugate for chemo-immunotherapy of triple-negative breast cancers
SUMMARY Triple-negative breast cancers (TNBCs) are highly aggressive and often relapse post standard cytotoxic chemotherapies. The immunotherapies such as immune checkpoint blocker...
Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment
ABSTRACT The psychosocial care of patients with advanced lung cancer (ALC) has not kept pace with current medical treatments, creating significant gaps in care. Treatments like imm...
Evaluation of a therapeutic vaccination strategy with motif neoepitope peptide-pulsed autologous dendritic cells for non-small cell lung cancer patients harboring a charged HLA-B binding pocket.
PROJECT SUMMARY Lung cancer is the leading cause of cancer related deaths in the United States and the World. Inefficient prediction of functional tumor neoantigens and insufficien...
Interventional method development for multiplexed personalized drug evaluation using implantable microdevices
Abstract: Novel implantable miniaturized devices (IMDs) placed directly in patient tumors can rapidly evaluate multi-drug responses in-situ. They can be used in any solid tumor to...
Community Services Navigation to Advance Health Equity in Breast Cancer Screening
Project Abstract Community Services Navigation to Advance Health Equity in Breast Cancer Screening Persistent inequities in breast cancer outcomes can be traced in large part to in...
Novel therapeutics for the targeted eradication of DDR-defective tumors
PROJECT SUMMARY/ABSTRACT. O6-Methylguanine methyltransferase (MGMT) reverts O6-alkylguanosine residues to guanosine via dealkylation by SN2 displacement. MGMT is ubiquitously expre...
Facilitation of Information Exchange for Shared Decision Making for Lung Cancer Screening
ABSTRACT I am a pulmonary critical care physician at the UMass Chan Medical School and a former scholar of the Massachusetts Consortium for Cardiopulmonary Implementation Science p...
EARLY ONSET MALIGNANCIES INITIATIVE CLINICAL DATA CENTER
EARLY ONSET MALIGNANCIES INITIATIVE CLINICAL DATA CENTER
Facilitation of Information Exchange for Shared Decision Making for Lung Cancer Screening
ABSTRACT I am a pulmonary critical care physician at the UMass Chan Medical School and a former scholar of the Massachusetts Consortium for Cardiopulmonary Implementation Science p...
Trispecific CAR-T cells targeting CD19, CD20 and CD22 to treat B-cell malignancies
Project summary CD19 targeted chimeric antigen receptor T cells (CAR-Ts) have revolutionized cellular immunotherapy in refractory B-cell malignancies such as B-cell Non-Hodgkin’s l...
Targeting myeloid suppression to enhance anti-tumor immunity in breast cancer
Project Summary Myeloid immune suppression, driven by macrophages and monocytes, is a known mechanism of intrinsic resistance to immune checkpoint inhibition (ICI), which has provi...
Trispecific CAR-T cells targeting CD19, CD20 and CD22 to treat B-cell malignancies
Project summary CD19 targeted chimeric antigen receptor T cells (CAR-Ts) have revolutionized cellular immunotherapy in refractory B-cell malignancies such as B-cell Non-Hodgkin’s l...
Targeting myeloid suppression to enhance anti-tumor immunity in breast cancer
Project Summary Myeloid immune suppression, driven by macrophages and monocytes, is a known mechanism of intrinsic resistance to immune checkpoint inhibition (ICI), which has provi...
BCC for Prostate Cancer: Discovery and Translation of Biomarkers for Clinical Unmet Needs
Active surveillance (AS) is the preferred management option for low risk prostate cancer (PCa) patients who would benefit from conservative treatment. However, due to the lack of r...