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20,252 grants found
Showing 3,941 – 3,960 of 20,252 grants
Exploiting cell fate transition to overcome radiation resistance in glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is a devastating brain tumor that affects about 15,000 Americans every year. Despite maximal surgical resection and chemoradiation, GBMs remain i...
Mechanisms of tumor cell clustering in breast cancer metastasis
Metastasis is the primary cause of breast cancer-related morbidity and mortality. During metastasis, cells from primary tumors shed into the bloodstream as circulating tumor cells...
Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy
Priming of antitumor immunity relies on a specialized subset of conventional Dendritic Cells (cDC1s), CD103+ DCs, that have unique capabilities of trafficking tumor antigens to lym...
Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy
Priming of antitumor immunity relies on a specialized subset of conventional Dendritic Cells (cDC1s), CD103+ DCs, that have unique capabilities of trafficking tumor antigens to lym...
Targeting FOXP3 mRNA splicing for breast cancer immunotherapy
Project Abstract The development of cancer immunotherapy including immune checkpoint inhibitors and adoptive cell transfer (ACT)-based therapies revolutionized cancer treatment. Th...
Identifying metabolic dependencies in Hurthle cell carcinoma of the thyroid-Res 1
Project Summary: Cancers require metabolic adaptations to support the unbridled proliferation that drives tumor growth. Mutations in the mitochondrial genome (mtDNA) are observed i...
SUPPLEMENT TO THE JOURNAL OF THE NATIONAL CANCER INSTITUTE (JNCI) MONOGRAPHS 50TH ANNIVERSARY ISSUE OF THE NATIONAL CANCER INSTITUTE'S SEER PROGRAM: A HALF-CENTURY OF TURNING CANCER DATA INTO DISCOVE
The SEER Program celebrates is 50th anniversary in 2023 and has contracted with the Oxford University Press to publish a special monograph within the Journal for the National Cance...
SCIENTIFIC SUPPORT SERVICES FOR THE NATIONAL CANCER INSTITUTE, DIVISION OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS), CALL ORDER 3 UNDER BPA #HHSN261201800002B
The Contract effort objective is to provide management, scientific, and technical support to core activities in the Division of Cancer Control and Population Science (DCCPS). Resul...
Identifying metabolic dependencies in Hurthle cell carcinoma of the thyroid-Res 1
Project Summary: Cancers require metabolic adaptations to support the unbridled proliferation that drives tumor growth. Mutations in the mitochondrial genome (mtDNA) are observed i...
Targeting FOXP3 mRNA splicing for breast cancer immunotherapy
Project Abstract The development of cancer immunotherapy including immune checkpoint inhibitors and adoptive cell transfer (ACT)-based therapies revolutionized cancer treatment. Th...
Multisite Implementation of COMPRENDO (ChildhOod Malignancy Peer REsearch NavigatiOn) to improve participation of Hispanic children in cancer clinical trials
PROJECT SUMMARY Childhood cancer is the leading cause of death by disease past infancy in the U.S. While survival rates are improving, stark racial/ethnic disparities remain. Hispa...
Neoadjuvant Neratinib in Stage I-III HER2-mutated Lobular Breast Cancer
BACKGROUND: Invasive lobular carcinoma (ILC) accounts for approximately 10-15% of all breast cancers and is characterized by hormone receptor positivity (HR+), lack of HER2 amplifi...
Genetic Epidemiology of Hepatocellular Carcinoma in African Americans
Project Summary/Abstract Over the past three decades, hepatocellular carcinoma (HCC) emerged as the fastest growing cancer in the U.S. With cure being possible in less than 10% of...
Predicting Future Liver Remnant Function and Growth Trajectory Using Novel MR Imaging Biomarkers
PROJECT ABSTRACT Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths in the world. In fact, HCC is the fastest growing cause of all cancer deaths in...
FURTHER DEVELOPMENT OF IPSC-BASED VACCINE FOR COLON CANCER PREVENTION
Colorectal Cancer (CRC) is the third most common cancer diagnosed in men and women, and the second leading cause of cancer death in the US. While the evidence supports that CRC-scr...
Multisite Implementation of COMPRENDO (ChildhOod Malignancy Peer REsearch NavigatiOn) to improve participation of Hispanic children in cancer clinical trials
PROJECT SUMMARY Childhood cancer is the leading cause of death by disease past infancy in the U.S. While survival rates are improving, stark racial/ethnic disparities remain. Hispa...
Neoadjuvant Neratinib in Stage I-III HER2-mutated Lobular Breast Cancer
BACKGROUND: Invasive lobular carcinoma (ILC) accounts for approximately 10-15% of all breast cancers and is characterized by hormone receptor positivity (HR+), lack of HER2 amplifi...
Genetic Epidemiology of Hepatocellular Carcinoma in African Americans
Project Summary/Abstract Over the past three decades, hepatocellular carcinoma (HCC) emerged as the fastest growing cancer in the U.S. With cure being possible in less than 10% of...
Dual-payload antibody-drug conjugate for chemo-immunotherapy of triple-negative breast cancers
SUMMARY Triple-negative breast cancers (TNBCs) are highly aggressive and often relapse post standard cytotoxic chemotherapies. The immunotherapies such as immune checkpoint blocker...
Community Services Navigation to Advance Health Equity in Breast Cancer Screening
Project Abstract Community Services Navigation to Advance Health Equity in Breast Cancer Screening Persistent inequities in breast cancer outcomes can be traced in large part to in...