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20,252 grants found
Showing 3,921 – 3,940 of 20,252 grants
Hypoxic regulation of macrophage migration and function via fibroblast reprogramming in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States despite representing only 2% of all cancer cases. P...
Regulation of hematopoiesis during tumor progression
Project Summary/Abstract The immune system plays an important role during tumor progression, having the ability to recognize and kill tumor cells (T cells and NK cells) [1]. Unfort...
Rapid, simple, and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy
Abstract While a growing arsenal of drugs is available to treat specific molecular abnormalities across cancers, therapy effectiveness can now be predicted by detecting specific ge...
Inter-metastatic divergency in small cell lung cancer; implications for the design of future immunotherapies
Abstract Aggressive malignant progression and spreading has limited a clear understanding of the pathophysiology of SCLC. The overarching goal of this “bedside to bench” project is...
Engineering Protein Modulators of Notch Activation for T-cell immunotherapy
Summary Investigators at the University of Minnesota have teamed up to engineer novel protein activators of the Notch family of cell surface receptors, which are master regulators...
Advanced Sample Preparation, Separation and Multiplexed Analysis for In-Depth Proteome Profiling of >1000 Single Cells Per Day
PROJECT SUMMARY/ABSTRACT Cancer tissues exhibit a high degree of phenotypic heterogeneity and plasticity and contain numerous subpopulations of cells in various states. Quantifying...
Development and Implementation of Advanced Technologies for Cancer Metabolism Research
PROJECT SUMMARY This proposal requests support for my position as the Director of the Cancer Metabolism Core at Sanford Burnham Prebys Medical Discovery Institute (SBP). The Core i...
Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is particularly resistant to therapy and typically presents as metastatic disease. Characterized by hypoxia, dense stroma, and meta...
The role of ARID1A mutations in Latino gastric cancer biology and disparities
PROJECT SUMMARY/ABSTRACT The University of California and the University of Texas Southwestern (UCaTS) Diversity Patient-Derived Xenograft (PDX) Development and Trial Center’s is a...
Cancer biology and pre-clinical studies of BRCAness in Latino gastric tumors
PROJECT SUMMARY/ABSTRACT The University of California and the University of Texas Southwestern (UCaTS) Diversity Patient-Derived Xenograft (PDX) Development and Trial Center’s is a...
Personalized neoantigen vaccines using nucleoside-modified mRNA-lipid nanoparticles
PROJECT SUMMARY: U01 CA217959 Supplement Application This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-029. The pare...
Immunoregulatory Mechanisms of BiTE Efficacy in the Cold Neuroblastoma TME
ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-24-029. Bispecific T cell engagers (BTE) connect cancer cells...
Targeting Macrophages to Treat Soft Tissue Sarcomas
PROJECT SUMMARY Soft tissues sarcomas (STS) is a broad term for multiple subtypes of cancer that start in soft tissues. Most STS are treated in the same way in the clinic regardles...
Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
ABSTRACT Targeted cancer therapy, in the form of tyrosine kinase inhibitors, has been a game changer for patients with cancers driven by activating mutations in genes encoding thes...
Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
ABSTRACT Targeted cancer therapy, in the form of tyrosine kinase inhibitors, has been a game changer for patients with cancers driven by activating mutations in genes encoding thes...
Tumor Monorail Device for Serial Glioblastoma Biopsy
Project Summary/Abstract Glioblastoma (GBM) is one of the most common and deadliest form of malignant brain tumors, with median patient survival of 12-15 months and five-year survi...
The Promoting Resilience in Stress Management (PRISM) Intervention: a multi-site randomized controlled trial for Adolescents and Young Adults with advanced cancer
PROJECT SUMMARY Cancer among Adolescents and Young Adults (AYAs) is particularly difficult because age-related developmental challenges of identity, relationships, and vocation may...
Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy
Priming of antitumor immunity relies on a specialized subset of conventional Dendritic Cells (cDC1s), CD103+ DCs, that have unique capabilities of trafficking tumor antigens to lym...
Exploiting cell fate transition to overcome radiation resistance in glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is a devastating brain tumor that affects about 15,000 Americans every year. Despite maximal surgical resection and chemoradiation, GBMs remain i...
Mechanisms of tumor cell clustering in breast cancer metastasis
Metastasis is the primary cause of breast cancer-related morbidity and mortality. During metastasis, cells from primary tumors shed into the bloodstream as circulating tumor cells...