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20,252 grants found
Showing 3,901 – 3,920 of 20,252 grants
University of California and UT Southwestern D-PDTC
PROJECT SUMMARY/ABSTRACT The University of California and the University of Texas Southwestern (UCaTS) Diversity Patient-Derived Xenograft (PDX) Development and Trial Center’s is a...
Admin Core
PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish and characterize a large collection of minority patient-derived cancer xenografts (PDXs) from two canc...
PDX Core
PROJECT SUMMARY/ABSTRACT The primary objectives of the Patient Derived Xenograft (PDX) Core will be to establish and characterize PDXs, and to support the research aims of the two...
Bioinformatics Core
PROJECT SUMMARY The overall objective of the proposed Diversity PDX Development and Testing Center (D-PDTC) is directed at improving cancer precision medicine approaches for gastri...
Advancing gastric cancer precision medicine in Latinos through patient-derived modeling
PROJECT SUMMARY/ASTRACT Gastric cancer (GC) is a leading cause of cancer incidence, mortality, and survival disparities in Latinos, the largest and youngest U.S. minority and the l...
Characterizing treatment responses for common lung cancer (LC) subtypes in Latinos and Asians
SPECIFIC AIMS The purpose of UCaTS Project 2 is to target clinically important genomic markers of early resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant non...
Pilot Projects and Trans-Network Activities
PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) to Redu...
Cannabis for Palliative Care in Cancer: A Placebo-controlled Randomized Trial of Full Spectrum Hemp-derived CBD/THC
Project Summary Problems with pain, sleep, and mood are common among individuals diagnosed with cancer (i.e., cancer survivors/patients), and many are turning to cannabis for sympt...
Neoantigen-specific T cells in a novel cutaneous squamous cell carcinoma model
Abstract: More than one million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed annually in the US and approximately 4% of patients develop metastases and 2% die of...
Elucidating the distinct roles of T cell-polarized microglia in glioblastoma suppression and progression
Project Summary/Abstract Glioblastoma is a grade IV diffuse astrocytoma, the deadliest and most common form of adult brain cancer. Standard of care extends survival by approximatel...
Mechanism of cell lethality following loss of gene expression.
PROJECT SUMMARY The goal of this project is to determine the mechanism by which cell death results from transcriptional inhibition. The consensus model in the field posits that cel...
Mitochondrial Regulation of Interferon Response in Melanoma
PROJECT SUMMARY Interferons (IFNs) are central orchestrators of tumor immunity and can elicit both pro-tumor and anti-tumor responses depending on the cancer cell type, the type of...
Delineating Functional Immunity via Image-Guided PET
Abstract Immunotherapy has made an enormous impact in the treatment of multiple types of cancer, however most patients fail to benefit and methods to monitor response are lacking....
Sulindac sensitizes colorectal cancer to anti-PD-L1 therapy
Project Summary: The overall survival of colorectal cancer (CRC) patients has improved significantly over the past few decades, but the 5-year survival rate for patients with stage...
Defining pro-metastatic and endothelial-regulatory roles for LIN28B in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) is a lethal solid tumor that is highly dependent on recruitment of new blood vessels and has no common genomic targets. As for most s...
Mechanisms of REST-mediated immunosuppression in cancer
Project Abstract Tumor-intrinsic factors in cancer cells modulate the immune milieu to enable prolonged survival and growth of tumors. In breast cancer (BC), the 2nd leading cause...
The Role of SKIDA1 in Acute Myeloid Leukemia Initiation and Maintenance
ABSTRACT Chromosomal translocations involving the MLL1 gene often drive infant acute myeloid leukemia (AML). MLL fusion proteins (e.g., MLL-ENL, MLL-AF9, MLL-AF10) activate self-re...
Studying the role of TERRA in telomere protection and length regulation
PROJECT SUMMARY Telomeres are specialized DNA-protein complex that protect the ends of linear chromosomes. Mammalian telomeres are composed of highly conserved tandem repeat sequen...
Effects of entinostat and neoantigen vaccination on bladder cancer
Project Summary/Abstract Bladder cancer is a prevalent and deadly cancer, with over 80,000 new cases and 17,000 deaths annually in the United States. Advanced bladder cancer has on...
Evaluation of Patient Factors and Sample Pre-Analytics on Predictive Multiplex Immunohistochemical Assays in Immuno-Oncology Patients
Project Summary/Abstract Therapies against immunologic checkpoint proteins, such as PD-L1, have revolutionized the treatment of multiple malignancies, such as malignant melanoma, l...