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20,252 grants found
Showing 3,881 – 3,900 of 20,252 grants
The Role of Platelets in Establishing the Lung Pre-Metastatic Niche in Breast Cancer
PROJECT SUMMARY Tumor metastasis remains responsible for >65% of cancer-associated mortality and nearly all breast cancer deaths. Given the difficulties in treating metastatic d...
Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy
PROJECT SUMMARY/ABSTRACT Millions of women worldwide have undergone mastectomy and breast reconstruction procedures. Simple (also called total) mastectomy, the most common mastecto...
Pathway-guided treatment of immune checkpoint inhibitor therapy-induced colon toxicity
Abstract Development of immune-related adverse effects (irAEs) is one of the significant challenges of current approved cancer therapy with immune checkpoint inhibitors (ICIs) of t...
Defining the role of tumoral MHC Class I Expression in Mediating Colorectal Cancer Racial Disparities
PROJECT SUMMARY Compared to Whites, African American/Blacks (AA/B) have a substantially higher (40-50%) colorectal cancer (CRC) mortality rate that is a function of both higher inc...
The abuse liability, topography and toxicology of ice flavors and non-menthol synthetic cooling agents in e-cigarette products
PROJECT SUMMARY Recently, synthetic cooling agents, WS-3 (N-ethyl-p-menthane-3-carboxamide) and WS-23 (2-isopropyl-N,2,3 trimethylbutyramide), that solely impart a cooling sensatio...
The AVANÇO Research Consortium: A Mozambique/Brazil/Texas Alliance to advance novel and affordable technologies for the prevention and diagnosis of cervical cancer in women living with HIV
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Admin Core
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Project 1
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Project 2
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Shared Resources Core
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Developmental Core
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Dissecting Neuro-Immune Interactions in Cancer
PROJECT SUMMARY/ABSTRACT: Cancer is highly adept at exploiting normal physiological functions to support its growth. One important component of tissue physiology is neurons which w...
Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is particularly resistant to therapy and typically presents as metastatic disease. Characterized by hypoxia, dense stroma, and meta...
Reducing the chasm in behavioral health care for older adults with cancer: Development of the Center for Implementation Research in Cancer in Later Life (CIRCL)
PROJECT SUMMARY Older adults with cancer (OACs) comprise a large and growing proportion of cancer patients and survivors. Many OACs have unmet behavioral health needs with signific...
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
PROJECT SUMMARY: Radiotherapy can be a highly effective treatment for many types of cancers. A major impediment to achieving its full curative promise is the current delivery proce...
Microfluidic technology to isolate tumoricidal T-cells from peripheral blood
PROJECT SUMMARY Adoptive cell transfer (ACT) using ex vivo expanded anti-tumor T-cells has garnered significant interest due to successes in treating melanoma and other cancers. Th...
Using natural killer cells to prevent breast cancer metastases
Project Summary/Abstract Most of breast cancer related mortality is related to metastatic disease. While NK cells play an essential role in the control of metastatic breast cancer...
OR2H1 is an effective target for CAR T cells in human epithelial tumors
ABSTRACT Identifying accessible tumor antigens that are not expressed in vital organs would allow genetic engineering of CAR T cells to avoid dysfunction at tumor beds. We have ide...
Defining kinase interaction pathways to enhance anti-cancer efficacy and minimize associated morbidities of kinase inhibitor drugs.
PROJECT SUMMARY The decreased quality of life and increased morbidity due to oncological drugs such as Tyrosine Kinase Inhibitors (TKIs) is a serious and growing general health pro...
Role of the CD44/Hyaluronan axis in mesenchymal prostate cancer
Lineage plasticity has emerged as an important mechanism of treatment resistance in prostate cancer that results into multiple different tumor states. Recent classifications effort...