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20,252 grants found
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Alternatively spliced cell surface proteins as drivers of leukemogenesis and targets for immunotherapy
Project Summary While impressive progress has been made in tumor immunology and clinical application of immunomodulatory agents in solid tumors, we don’t fully understand how to ef...
Engineering In Vivo Chimeric Antigen Receptor Macrophages (CARMs) using mRNA-exosomes for Cancer Immunotherapy
PROJECT SUMMARY Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic cancers. However, for solid tumors, CAR T cells face challenges inclu...
Clinical, molecular, and immune characterization of naturally occurring osteosarcoma in dogs
PROJECT SUMMARY Naturally occurring osteosarcoma in dogs has been proposed as a promising translational platform to serve as an intermediary between mouse studies and human clinica...
The role of PRMT5 in preventing intra-chromosomal deletions in cancer cells
Project Summary/Abstract PRMT5 is an arginine methyltransferase with key roles in cancer. The gene has pleiotropic functions ranging from gene regulation and development to modulat...
An Improved Epigenetic Algorithm for Guiding Low Dose CT Lung Cancer Screening
SPECIFIC AIMS Approximately 90% of lung cancer results from smoking. Low Dose Computerized Tomography (LDCT) of smokers can detect lung cancer earlier allowing more effective treat...
The role of the intestinal microbiome in cancer immunotherapy
ABSTRACT The gut microbiota consists of a community of diverse microbes and has many effects on human (patho)physiology. Microbiome composition has been associated with many diseas...
Understanding and addressing rejection of personalized cancer risk information
PROJECT SUMMARY/ABSTRACT We are entering an era of precision medicine for cancer screening in which screening initiation and maintenance is based on personal risk estimates that in...
Synthetic introns for selective targeting of RNA splicing factor-mutant leukemia
SUMMARY Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors, resulting in sequence-specific changes in RNA splicing that promote disease initi...
Using implantable microdevices for deep phenotyping of multiple drug responses in brain tumor patients
Gliomas are a particularly aggressive type of brain cancer with poor prognosis that affect about 20,000 newly diagnosed patients in the US annually. There is high interest in ident...
Discovering the Timing and Origins of Bone and Soft Tissue Cancers
SUMMARY Sarcomas are cancers of the bone and connective tissue that affect a higher proportion of children than adults. Many childhood sarcomas are difficult to diagnose, which can...
Secondary Cervical Cancer Prevention of Vulnerable Women with HPV and HIV Co-infection in India
ABSTRACT In India, cervical cancer (CC) remains one of the most common malignancies among women, with about 100,000 women diagnosed annually. HIV promotes the progression of precan...
Computational approaches to the mechanistic elucidation of the serrated pathway of human colon carcinogenesis
PROJECT SUMMARY This K25 Mentored Quantitative Research Development Award project proposal is to allow the PI, Dr. Marmar Moussa - an experienced Computer Scientist and Bioinformat...
Bispecific Antibody Therapeutics for Neuroblastoma and Diffuse Midline Glioma
PROJECT SUMMARY/ABSTRACT Clearly identified barriers have undermined the promise of immunotherapy for pediatric patients with solid or brain tumors. Most of these tumors lack genet...
Integrating liquid biopsy-based epigenetic and imaging modalities to evaluate disease response in multiple myeloma
PROJECT SUMMARY Multiple myeloma (MM) affects ~35,000 adult patients in the United States and causes ~12,000 deaths each year. Novel immunomodulatory drugs and effective multidrug...
Novel mechanism of induction of tumor pyroptosis by IL-9-secreting Tc9 cells
PROJECT SUMMARY Blood CD8+ T cells can be subdivided into different subsets based on their cytokine section profiles and functions. We have shown that IL-9-secreting CD8+ Tc9 cells...
FOXA1 regulates cytokine signaling and immune landscape in prostate cancer through ARID1A
Summary Prostate cancer (PCa) is the most commonly diagnosed cancer and the second leading cause of cancer death in American males. Androgen deprivation therapies and androgen rece...
Etiologic Heterogeneity Between Molecular Subtypes of Prostate Cancer
PROJECT SUMMARY This proposed project investigates the hypothesis that risk factors for prostate cancer differ by molecular subtype of the tumor. It addresses the conundrum that pr...
Microbial Dysbiosis in Pancreatic Cancer Initiation and Progression
Project Summary Pancreatic adenocarcinoma is a devastating disease with a five-year survival of only 10%. The rise of immunotherapy has led to breakthrough treatments in many cance...
Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging
1 2 functions, 3 have 4 spatial resolution and sensitivity. Such specifications impact both neurologic and neuro-oncologic diseases. In 5 the former, they allow detecting, quantita...
Transcriptional Regulation in ZFTA-RELA Ependymoma
SUMMARY Transcriptional networks in cancer are a collection of inputs from developmental and cell identity programs, oncogenic proteins, metabolic circuits, and micro-environmental...