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20,252 grants found
Showing 3,841 – 3,860 of 20,252 grants
Countering E-cigarette Marketing in the Retail Environment among Adolescents and Young Adults
PROJECT SUMMARY/ ABSTRACT Despite significant efforts to limit youth from accessing and using electronic cigarettes (e-cigarettes), many adolescents and young adults are directly p...
Defining pro-metastatic and endothelial-regulatory roles for LIN28B in hepatocellular carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) is a lethal solid tumor that is highly dependent on recruitment of new blood vessels and has no common genomic targets. As for most s...
Traditional and New Dietary Assessment Methods (TANDAM) for Personalized Nutrition
PROJECT SUMMARY/ABSTRACT Errors in dietary assessment methods attenuate the association between diet and chronic disease outcomes, such as obesity and cancer, which derails efforts...
A Novel Melanoma Vaccine Based on a Shared Neoantigen and a Liquid Polymer Platform
Abstract Despite the dramatic improvement in outcomes afforded by immune checkpoint inhibitors and targeted therapies, most patients with metastatic BRAF-mutated melanoma ultimatel...
Sulindac sensitizes colorectal cancer to anti-PD-L1 therapy
Project Summary: The overall survival of colorectal cancer (CRC) patients has improved significantly over the past few decades, but the 5-year survival rate for patients with stage...
Evaluation of Patient Factors and Sample Pre-Analytics on Predictive Multiplex Immunohistochemical Assays in Immuno-Oncology Patients
Project Summary/Abstract Therapies against immunologic checkpoint proteins, such as PD-L1, have revolutionized the treatment of multiple malignancies, such as malignant melanoma, l...
SEER TRAINING WEBSITE, NEW DATA ITEM FEASIBILITY STUDY, AND SEER ADVANCED TOPICS FOR REGISTRY PROFESSIONALS WORKSHOP TECHNICAL AND LOGISTICAL SUPPORT
TECHNICAL AND LOGISTICAL SUPPORT for -SEER TRAINING WEBSITE, -NEW DATA ITEM FEASIBILITY STUDY, -AND SEER ADVANCED TOPICS FOR REGISTRY PROFESSIONALS WORKSHOP
A Type I Hybrid Effectiveness-Implementation Trial to Evaluate a Navigation-Based Multilevel Intervention to Decrease Delays Starting Adjuvant Therapy Among Patients with Head and Neck Cancer
PROJECT SUMMARY/ABSTRACT This R01 proposal aims to test the effectiveness, mechanism, and implementation of a navigation-based multilevel intervention to improve the delivery of ti...
HMGB1 in EB-Associated Squamous Cell Carcinoma
Project Summary/Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic disease characterized by chronic wounds and shortened lifespan due to a high incidence...
Therapy-induced cognitive impairment in a rat model of prostate cancer
Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment. However, ADT has adverse effects, including cognitive impairment that compromises quality of life for...
LncRNA EPIC1 induces immunotherapy resistance by activating EZH2 in breast cancer
Summary:On July 26, 2021, the FDA approved the anti-PD1 immunotherapy pembrolizumab (Keytruda®, Merck) for triple negative breast cancer (TNBC) patients. Although significant progr...
Evaluating a remotely delivered, digital health CRC screening intervention among racially diverse patients of a community health center
Project Summary/Abstract Colorectal cancer (CRC) screening is one of the most effective tools to reduce cancer morbidity and mortality. Yet, CRC screening rates at federally qualif...
Targeting PLK1 signaling for the treatment of fibrolamellar carcinoma
PROJECT SUMMARY Fibrolamellar carcinoma (FLC) is a childhood liver cancer with a high case mortality rate. Patients with FLC typically present with advanced disease, as there are n...
Dissecting the tumor-intrinsic and -extrinsic roles of TBK1 in tumor immunity
Project Summary Immune checkpoint blockade (ICB) targeting the PD-1/PD-L1 pathway has induced dramatic and durable clinical responses in melanoma and other cancers. Despite the suc...
Exploring the Role of Nitrogen Metabolism in Cancer
PROJECT SUMMARY/ABSTRACT There has been a renewed interest in how oncogenic driver mutations and tumor suppressor losses contribute to cancer-associated alterations in cellular met...
Validation of an aqueous humor liquid biopsy for molecular prognostication and monitoring of children with retinoblastoma.
Project Summary There is a significant body of research into the genetic, genomic and epigenomic alterations of retinoblastoma (RB), a primary eye cancer that forms in the developi...
Investigating the roles of oncogenic extrachromosomal circular DNAs in cancer
ABSTRACT Increased oncogene expression mediated by focal amplifications is a common mechanism for oncogene activation in human cancers. Two major mechanisms leading to oncogene amp...
Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
ABSTRACT Targeted cancer therapy, in the form of tyrosine kinase inhibitors, has been a game changer for patients with cancers driven by activating mutations in genes encoding thes...
Assessment of a Radiomics-Based Computer-Aided Diagnosis Tool for Cancer Risk Stratification of Pulmonary Nodules
PROJECT SUMMARY/ABSTRACT This proposal describes a comprehensive 5-year mentored career development plan with the goal of training the candidate to become a leading independent phy...
Personalized neuroblastoma vaccines
PROJECT SUMMARY This Multiple Principal Investigator (MPI) Project proposal for the Pediatric Immunotherapy Network is focused on high-risk neuroblastoma, a diverse and enigmatic m...