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20,252 grants found
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CSHL 2023 Conference on Biology of Cancer: Microenvironment & Metastasis
Biology of Cancer: Microenvironment & Metastasis Cold Spring Harbor, New York September 19 – 23, 2023 ABSTRACT Cancer is now recognized as an abnormal organ where multiple cell...
Regulation of hematopoiesis during tumor progression
Project Summary/Abstract The immune system plays an important role during tumor progression, having the ability to recognize and kill tumor cells (T cells and NK cells) [1]. Unfort...
Effects of entinostat and neoantigen vaccination on bladder cancer
Project Summary/Abstract Bladder cancer is a prevalent and deadly cancer, with over 80,000 new cases and 17,000 deaths annually in the United States. Advanced bladder cancer has on...
Label-free imaging of CAR T cell metabolism
PROJECT SUMMARY / ABSTRACT The goal of this proposal is to develop non-invasive single-cell technologies to improve the potency of T cell therapies against cancer. The first 6 chim...
Mechanism of cell lethality following loss of gene expression.
PROJECT SUMMARY The goal of this project is to determine the mechanism by which cell death results from transcriptional inhibition. The consensus model in the field posits that cel...
Engineering In Vivo Chimeric Antigen Receptor Macrophages (CARMs) using mRNA-exosomes for Cancer Immunotherapy
PROJECT SUMMARY Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic cancers. However, for solid tumors, CAR T cells face challenges inclu...
Defining the Biological Arc of Grade Group 1 Prostate Cancer
The long-term goal of this project is to further reduce the biological uncertainty associated with surveillance for favorable-risk prostate cancer. Although most men with favorable...
Tumor-intrinsic and paracrine roles of endoglin in pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy featuring early metastasis, late onset of symptoms, and notorious resistance to existing therapies. A critic...
Human specific STING agonists for the treatment of cancer
PROJECT SUMMARY Cellular innate immune sensors, such as STING (STIMULATOR OF INTERFERON GENES), have evolved to detect microbial infection of the cell (1-3). STING controls the pot...
Prostate Specific Anti-androgen Therapy for Localized Prostate Cancer
Abstract Prostate cancer is the most common malignancy in men worldwide and its incidence is steadily rising. Treatment options for early-stage prostate cancer include radical pros...
Development of peptide drug conjugates for cancer therapy
Abstract The ultimate goal of this project is to develop and commercialize peptide drug conjugates to treat life- threatening triple negative breast cancer. Triple negative breast...
Tumor Monorail Device for Serial Glioblastoma Biopsy
Project Summary/Abstract Glioblastoma (GBM) is one of the most common and deadliest form of malignant brain tumors, with median patient survival of 12-15 months and five-year survi...
Targeting Macrophages to Treat Soft Tissue Sarcomas
PROJECT SUMMARY Soft tissues sarcomas (STS) is a broad term for multiple subtypes of cancer that start in soft tissues. Most STS are treated in the same way in the clinic regardles...
An Improved Epigenetic Algorithm for Guiding Low Dose CT Lung Cancer Screening
SPECIFIC AIMS Approximately 90% of lung cancer results from smoking. Low Dose Computerized Tomography (LDCT) of smokers can detect lung cancer earlier allowing more effective treat...
Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma
Project Summary The Kaposi's sarcoma-associated herpesvirus (KSHV) causes the AIDS-defining B cell malignancy, primary effusion lymphoma (PEL). KSHV is found in all tumor cell...
Secondary Cervical Cancer Prevention of Vulnerable Women with HPV and HIV Co-infection in India
ABSTRACT In India, cervical cancer (CC) remains one of the most common malignancies among women, with about 100,000 women diagnosed annually. HIV promotes the progression of precan...
Combining immunotherapy with molecularly targeted radiation therapy
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICI) have limited single agent activity in metastatic castration resistant prostate cancer (mCRPC), in part related to the lo...
Defining the role of tumoral MHC Class I Expression in Mediating Colorectal Cancer Racial Disparities
PROJECT SUMMARY Compared to Whites, African American/Blacks (AA/B) have a substantially higher (40-50%) colorectal cancer (CRC) mortality rate that is a function of both higher inc...
Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging
1 2 functions, 3 have 4 spatial resolution and sensitivity. Such specifications impact both neurologic and neuro-oncologic diseases. In 5 the former, they allow detecting, quantita...
DATA MANAGEMENT FOR CANCER DIAGNOSIS PROGRAM ACTIVITIES
The National Cancer Institute (NCI) is an institute within the National Institutes of Health (NIH), one of eight agencies that compose the Public Health Service (PHS), Department o...