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20,252 grants found
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Transcriptional Regulation in ZFTA-RELA Ependymoma
SUMMARY Transcriptional networks in cancer are a collection of inputs from developmental and cell identity programs, oncogenic proteins, metabolic circuits, and micro-environmental...
Southwest EDRN Clinical Validation Center for Head and Neck Cancer
Project Summary/Abstract The goal of the EDRN Southwest Clinical Validation Center for Head and Neck Cancer is to improve oropharyngeal cancerscreening through the rigorous validat...
Inducing Tumor Neoantigens Through RNA Editing for Cancer Immunotherapy
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy but remain effective in only a subset of patients and tumor types. The success...
Novel Triple-Negative Breast cancer vulnerability governed by PNPT1-mediated RNA decay
PROJECT SUMMARY / ABSTRACT Breast cancer is the most common cancer and the leading cause of cancer death in females. Triple negative breast cancer (TNBC) is a highly aggressive and...
Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemia
PROJECT SUMMARY Phosphatases and kinases are established classes of drug targets in oncology due to the presence of structured catalytic pockets or allosteric sites that can be tar...
HLA B44 motif neoepitopes in NSCLC: Evaluating their effects on the TME and adding them to established markers in a model to predict durable benefit from PD- 1 inhibition with and without chemotherapy
PROJECT SUMMARY Lung cancer is the leading cause of cancer related deaths in the United States and the World. We recently demonstrated that programmed cell death 1 (PD-1) inhibitor...
Leveraging Health Systems to Increase Implementation of Evidence-based Surgical Cancer Care
PROJECT SUMMARY Hospitals are increasingly consolidating into health systems with shared ownership and management. Care in a health system has potential benefits for surgical cance...
RepurPosed AntiretrOviraL ThErapieS to EliminAte Cervical Cancer (POLESA Trial)
R37CA284033In the absence of cytology- and HPV-based cervical cancer screening, screening of the cervix by visual inspection after application of acetic acid (VIA) to highlight pre...
Utilizing Multi-omics to Facilitate Cancer Biology Research
Project Summary As a member of the E. Alejandro Sweet-Cordero laboratory my efforts are directed at executing the computational aspects of the grants, manuscripts, and the general...
Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma
Project Summary The Kaposi's sarcoma-associated herpesvirus (KSHV) causes the AIDS-defining B cell malignancy, primary effusion lymphoma (PEL). KSHV is found in all tumor cell...
Defining the Biological Arc of Grade Group 1 Prostate Cancer
The long-term goal of this project is to further reduce the biological uncertainty associated with surveillance for favorable-risk prostate cancer. Although most men with favorable...
Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer
SUMMARY Hormone receptor (HR)+ breast cancer (BC) causes the majority of BC-related deaths in the US, reflecting an unmet need for innovative therapeutic approaches. Indeed, resist...
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
PROJECT SUMMARY/ABSTRACT Lung cancer is the leading cause of cancer death in the United States, and lung cancer screening has been demonstrated to effectively reduce lung cancer by...
Elucidating the distinct roles of T cell-polarized microglia in glioblastoma suppression and progression
Project Summary/Abstract Glioblastoma is a grade IV diffuse astrocytoma, the deadliest and most common form of adult brain cancer. Standard of care extends survival by approximatel...
The Hematologic Malignancies Conference
SUMMARY/ABSTRACT The goal of this R13 application is to provide partial support to the 2023 Scientific Research Conference on Hematologic Malignancies administered by the Federatio...
Pathway-guided treatment of immune checkpoint inhibitor therapy-induced colon toxicity
Abstract Development of immune-related adverse effects (irAEs) is one of the significant challenges of current approved cancer therapy with immune checkpoint inhibitors (ICIs) of t...
Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemia
PROJECT SUMMARY Phosphatases and kinases are established classes of drug targets in oncology due to the presence of structured catalytic pockets or allosteric sites that can be tar...
Bionic Breast Project: A Neuroprosthesis to Restore Touch Sensation and Reduce Chronic Pain After Mastectomy
PROJECT SUMMARY/ABSTRACT Millions of women worldwide have undergone mastectomy and breast reconstruction procedures. Simple (also called total) mastectomy, the most common mastecto...
Mechanisms of REST-mediated immunosuppression in cancer
Project Abstract Tumor-intrinsic factors in cancer cells modulate the immune milieu to enable prolonged survival and growth of tumors. In breast cancer (BC), the 2nd leading cause...
The role of PTEN in epigenetic and metabolic regulation of IDH-mutant gliomas
ABSTRACT Astrocytic tumors of the central nervous system (CNS) are intractable tumors and harbor dismal outcomes due to a lack of targeted treatment options. More than 70% of astro...