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20,252 grants found
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Functional and Pharmacologic Investigation of the NUP98 Fusion Oncoprotein Interactome
PROJECT SUMMARY Chromosomal translocations involving Nucleoporin 98 (NUP98) are observed in approximately 5% of pediatric acute myeloid leukemia (AML) and are associated with resis...
Emerging role of tumor-derived exosomes in immune modulation and breast cancer health disparity.
Project Abstract Triple-negative breast cancer (TNBC) is an aggressive and invasive breast cancer subtype, accounting for 10-15% of breast cancer diagnoses. TNBC affects African-Am...
Transcriptional Activation of p62 by the master antioxidant NRF2 in EBV latency
Project Summary EBV infection is associated with a panel of diseases and cancers, and serves as a fascinating paradigm for the study of host-virus interactions. Oxidative stress is...
The role of PRMT5 in preventing intra-chromosomal deletions in cancer cells
Project Summary/Abstract PRMT5 is an arginine methyltransferase with key roles in cancer. The gene has pleiotropic functions ranging from gene regulation and development to modulat...
Discovering the Timing and Origins of Bone and Soft Tissue Cancers
SUMMARY Sarcomas are cancers of the bone and connective tissue that affect a higher proportion of children than adults. Many childhood sarcomas are difficult to diagnose, which can...
A Pilot Feasibility Study of an Intervention to Decrease Overtreatment of Low-risk Thyroid Cancer
PROJECT SUMMARY Nearly 90% of patients with low-risk papillary thyroid cancer undergo total thyroidectomy, the treatment option with the greatest morbidity, even though less invasi...
The biological effect and the mode of action of the CXCL7-CXCL12 chemokine heterodimer
ABSTRACT Chemokines are essential in health and disease such as infections, autoimmune diseases, atherosclerosis, HIV/AIDS, and cancer. Many chemokines engage in heterophilic inter...
Early response to radiotherapy and immunotherapy in rectal cancer: an integrated molecular, cellular, and spatial approach
Project Abstract With increased incidence in young populations and ~65% three-year survival of high-risk locally advanced rec- tal cancer, innovative approaches to improve outcomes...
Exploring the Role of Nitrogen Metabolism in Cancer
PROJECT SUMMARY/ABSTRACT There has been a renewed interest in how oncogenic driver mutations and tumor suppressor losses contribute to cancer-associated alterations in cellular met...
Using implantable microdevices for deep phenotyping of multiple drug responses in brain tumor patients
Gliomas are a particularly aggressive type of brain cancer with poor prognosis that affect about 20,000 newly diagnosed patients in the US annually. There is high interest in ident...
The role of the intestinal microbiome in cancer immunotherapy
ABSTRACT The gut microbiota consists of a community of diverse microbes and has many effects on human (patho)physiology. Microbiome composition has been associated with many diseas...
Regulation of RNA Decapping and Degradation: A novel approach to prostate cancer therapy
Prostate cancer (PCa) is the most frequent killer of men with over 34,000 deaths per year. If PCa is not cured by initial definitive surgery and/or radiation and spreads to lymph n...
Reducing the chasm in behavioral health care for older adults with cancer: Development of the Center for Implementation Research in Cancer in Later Life (CIRCL)
PROJECT SUMMARY Older adults with cancer (OACs) comprise a large and growing proportion of cancer patients and survivors. Many OACs have unmet behavioral health needs with signific...
LncRNA EPIC1 induces immunotherapy resistance by activating EZH2 in breast cancer
Summary:On July 26, 2021, the FDA approved the anti-PD1 immunotherapy pembrolizumab (Keytruda®, Merck) for triple negative breast cancer (TNBC) patients. Although significant progr...
Targeting PLK1 signaling for the treatment of fibrolamellar carcinoma
PROJECT SUMMARY Fibrolamellar carcinoma (FLC) is a childhood liver cancer with a high case mortality rate. Patients with FLC typically present with advanced disease, as there are n...
Therapy-induced cognitive impairment in a rat model of prostate cancer
Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment. However, ADT has adverse effects, including cognitive impairment that compromises quality of life for...
Circadian Clock and Myc-dependent Regulation of Cellular Transformation
The supplement instructions for PAR-22-114 state: “At a minimum, the Research Strategy section should be completed and must include a summary or abstract of the funded parent award...
Optimizing Treatment of Prostate Cancer in Men living with HIV
SUMMARY Cancer is a leading cause of morbidity and mortality among aging people with HIV (PWH) and prostate cancer is now one of the most common cancers among PWH. Despite this, pr...
Elucidating the mechanism of Ga13 mediated tumor suppression in pancreatic cancer
RESEARCH SUMMARY The heterotrimeric G proteins transduce signals from the G protein-coupled receptors (GPCRs), the largest class of cell surface proteins that regulate a wide varie...
Consequences of retrotransposition on genome integrity
Project SummaryTransposable elements are a major source of human genetic variation and also contribute to human diseases by causing somatic mutations. The activity of transposition...