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20,252 grants found
Showing 361 – 380 of 20,252 grants
IRS2 and mitotic regulation in breast cancer
Project Summary The overall goal of this proposal is to determine the mechanism by which Insulin Receptor Substrate 2 (IRS2) regulates the spindle assembly checkpoint (SAC) and to...
Mechanisms Driving the Rapid Evolution of Cancer Genomes
PROJECT SUMMARY/ABSTRACT The goal of this proposal is to identify the mechanism of catastrophic mutational processes that drive very rapid evolution of cancer genomes. One of these...
Radiation and dendritic cell combination to improve immunotherapy response in intrahepatic cholangiocarcinoma
Summary Intrahepatic cholangiocarcinoma (iCCA), the second most common primary liver cancer after hepatocellular carcinoma (HCC), is an aggressive malignancy with dismal overall pr...
Stromal targeting to improve the efficacy of systemically administered drugs for pancreatic ductal adenocarcinomas
Project Summary Only about 20% of pancreatic ductal adenocarcinoma (PDAC) patients are expected to survive one year from diagnosis, with the overall 5-year survival rate reported a...
Development of a novel survey to screen for chemotherapy-induced peripheral neuropathy in young children
PROJECT SUMMARY/ABSTRACT This application is developed to support Rozalyn Rodwin, MD, MHS, a current Assistant Professor in Pediatric Hematology-Oncology at Yale School of Medicine...
Decreasing Cardiometabolic Risk in Survivors of Childhood Cancer: Survivors engaged in Time-Restricted EatiNG after THerapy (STRENGTH)
PROJECT SUMMARY Over 500,000 survivors of childhood cancer are living in the United States today. Cardiovascular disease is the leading cause of noncancer late mortality in this co...
Molecular Mechanisms Underlying Luminal- Neuroendocrine Transdifferentiation
Summary The objective of this proposal is to determine the molecular mechanisms underlying luminal-to-neuroendocrine transdifferentiation (NET) of prostate cancer (PCa). NET underl...
3D Spatial Multi-Omics Profiling of Ovarian Cancer
Research Summary: High-grade serous ovarian cancer (HGSOC) is the most common histologic subtype of ovarian cancer. Despite ongoing efforts to develop effective surgical and treatm...
Center for Human Lymphoma Spatiotemporal Atlas (HuLymSTA)
SUMMARY Non-Hodgkinlymphomas (NHL) represent about 90% of all lymphomas diagnosed each year and is classified based on cell type - B cell, T cell and natural killer (NK) cell types...
Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D)
PROJECT SUMMARY This application aims to address the urgent need for precision in intercepting hereditary diffuse gastric cancer (HDGC) associated with pathogenic germline CDH1 mut...
A Multimodal 3D Atlas of Colorectal Cancer Across Ages of Onset
PROJECT SUMMARY We propose the construction of a three-dimensional (3D) multimodal molecular atlas of colorectal cancer (CRC) across different ages of onset of the disease. We aim...
Human Prostate Tumor Atlas Center
Project Summary Earlier gains in reducing prostate cancer (PCa) mortality, partially due to advances in screening and the use of androgen deprivation therapy to treat metastatic PC...
Pre-cancer atlas of skin cancer
The overarching goal of our proposal is to develop a pre-cancer atlas of skin cancer. Skin is an ideal model to study the early phases of tumorigenesis because it is easily accessi...
Genome-wide approaches to non-invasive screening and characterization of ovarian cancers
PROJECT SUMMARY Ovarian cancer is the deadliest gynecological cancer, in part because there is no widely used screening test and 80% of tumors are diagnosed at a late stage. Though...
An atlas of pancreatic tumorigenesis in the context of altered DNA repair occurring in high-risk individuals
PROJECT SUMMARY/ABSTRACT Pancreatic Ductal Adenocarcinoma (PDAC) is on track to become the second leading cause of cancer related deaths in the United States. This dismal prognosis...
Understanding the role of tumor microenvironment in low grade glioma progression to malignancy
ABSTRACT Our PCA research center brings together the UCLA Neurosurgery team with the Caltech spatial single cell team to construct a comparative spatial atlas of low-grade gliomas....
The Role of Guanine Exchange Factors in Pancreatic Ductal Adenocarcinoma (PDAC)
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a cancer with a poor prognosis and limited treatment options. Multiple lines of evidence have shown that cancer cells fre...
Investigating the Microenvironmental Dysregulation and Polypharmacy Impact during Acute Myeloid Leukemia in an in vitro model of the human bone marrow and in vivo models.
Project Summary and Abstract This award will support Azmeer Sharipol, M.S., long-term goal of developing the expertise and skills needed to become an independent investigator explo...
Desmoplastic small round cell tumor: harnessing new insights and new models
The desmoplastic small round cell tumor (DSRCT) remains one of the most lethal adolescent/young adult (AYA) sarcomas. The EWSR1-WT1 gene fusion is the primary and defining genetic...
PD-1 blockade effects on bone strength and metastatic progression
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) enable anti-tumor immunity by blocking immunoregulatory receptor-ligand interactions (e.g., programmed cell death protein 1 [PD-...