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20,252 grants found
Showing 3,761 – 3,780 of 20,252 grants
Southwest EDRN Clinical Validation Center for Head and Neck Cancer
Project Summary/Abstract The goal of the EDRN Southwest Clinical Validation Center for Head and Neck Cancer is to improve oropharyngeal cancerscreening through the rigorous validat...
Preclinical Validation of Personalized Molecular Assays for Measurable Residual Disease Monitoring in Pediatric AML
PROJECT SUMMARY/ABSTRACT My long-term career goal is to improve outcomes for pediatric patients with acute myeloid leukemia (AML), in part through development of improved modalitie...
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine
Project Summary Despite the progress made in precision oncology, clinicians typically face a vast volume and variety of next- generation sequencing and molecular data that is frequ...
Hypoxic regulation of macrophage migration and function via fibroblast reprogramming in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States despite representing only 2% of all cancer cases. P...
A Type I Hybrid Effectiveness-Implementation Trial to Evaluate a Navigation-Based Multilevel Intervention to Decrease Delays Starting Adjuvant Therapy Among Patients with Head and Neck Cancer
PROJECT SUMMARY/ABSTRACT This R01 proposal aims to test the effectiveness, mechanism, and implementation of a navigation-based multilevel intervention to improve the delivery of ti...
Autoantibodies to tumor-derived neoepitopes as biomarkers and immunoPET agents for the early detection of small cell lung cancer
Project Summary/Abstract Small-cell lung cancer (SCLC) kills over 30,000 Americans every year and has a dismal 5-year overall survival rate of less than 7%. However, SCLC outcomes...
Dissecting the tumor-intrinsic and -extrinsic roles of TBK1 in tumor immunity
Project Summary Immune checkpoint blockade (ICB) targeting the PD-1/PD-L1 pathway has induced dramatic and durable clinical responses in melanoma and other cancers. Despite the suc...
Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is particularly resistant to therapy and typically presents as metastatic disease. Characterized by hypoxia, dense stroma, and meta...
Clinical, molecular, and immune characterization of naturally occurring osteosarcoma in dogs
PROJECT SUMMARY Naturally occurring osteosarcoma in dogs has been proposed as a promising translational platform to serve as an intermediary between mouse studies and human clinica...
Enhancing TET activity for the treatment of hematological malignancy
PROJECT SUMMARY Advanced age in the majority of acute myeloid leukemia (AML) patients limits the use of aggressive chemotherapy leading to poor overall survival. Alternative treatm...
Investigating the roles of oncogenic extrachromosomal circular DNAs in cancer
ABSTRACT Increased oncogene expression mediated by focal amplifications is a common mechanism for oncogene activation in human cancers. Two major mechanisms leading to oncogene amp...
Validation of an aqueous humor liquid biopsy for molecular prognostication and monitoring of children with retinoblastoma.
Project Summary There is a significant body of research into the genetic, genomic and epigenomic alterations of retinoblastoma (RB), a primary eye cancer that forms in the developi...
Nuclear envelope and predisposition to hepatic neoplasia
PROJECT SUMMARY Chronic liver diseases such as nonalcoholic steatohepatitis significantly increase the risk of cirrhosis and hepatocellular carcinoma (HCC). However, the underlying...
The Role of Platelets in Establishing the Lung Pre-Metastatic Niche in Breast Cancer
PROJECT SUMMARY Tumor metastasis remains responsible for >65% of cancer-associated mortality and nearly all breast cancer deaths. Given the difficulties in treating metastatic d...
Leveraging Health Systems to Increase Implementation of Evidence-based Surgical Cancer Care
PROJECT SUMMARY Hospitals are increasingly consolidating into health systems with shared ownership and management. Care in a health system has potential benefits for surgical cance...
Dissecting Neuro-Immune Interactions in Cancer
PROJECT SUMMARY/ABSTRACT: Cancer is highly adept at exploiting normal physiological functions to support its growth. One important component of tissue physiology is neurons which w...
Inducing Tumor Neoantigens Through RNA Editing for Cancer Immunotherapy
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy but remain effective in only a subset of patients and tumor types. The success...
Synthetic introns for selective targeting of RNA splicing factor-mutant leukemia
SUMMARY Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors, resulting in sequence-specific changes in RNA splicing that promote disease initi...
Managing metabolic disruption in pancreatic cancer to prevent weight loss and improve quality of life
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the fourth-leading cause of cancer death in the United States, with 60 000 cases diagnosed annually and five-year surviva...
Microbial Dysbiosis in Pancreatic Cancer Initiation and Progression
Project Summary Pancreatic adenocarcinoma is a devastating disease with a five-year survival of only 10%. The rise of immunotherapy has led to breakthrough treatments in many cance...