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20,252 grants found
Showing 3,741 – 3,760 of 20,252 grants
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine
Project Summary Despite the progress made in precision oncology, clinicians typically face a vast volume and variety of next- generation sequencing and molecular data that is frequ...
Harnessing the repetitive genome for cancer immunotherapy
PROJECT SUMMARYThis KOS proposal describes a five-year career development training program in cancer epigenetics and tumor immunology. Dr. Gabriel Griffin has completed clinical tr...
Early response to radiotherapy and immunotherapy in rectal cancer: an integrated molecular, cellular, and spatial approach
Project Abstract With increased incidence in young populations and ~65% three-year survival of high-risk locally advanced rec- tal cancer, innovative approaches to improve outcomes...
A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches.
PROJECT SUMMARY The tumor microenvironment (TME) in essentially all epithelial cancers is associated with significant biochemical and structural changes in the extracellular matrix...
Enhancing TET activity for the treatment of hematological malignancy
PROJECT SUMMARY Advanced age in the majority of acute myeloid leukemia (AML) patients limits the use of aggressive chemotherapy leading to poor overall survival. Alternative treatm...
Tumor-intrinsic and paracrine roles of endoglin in pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy featuring early metastasis, late onset of symptoms, and notorious resistance to existing therapies. A critic...
Label-free imaging of CAR T cell metabolism
PROJECT SUMMARY / ABSTRACT The goal of this proposal is to develop non-invasive single-cell technologies to improve the potency of T cell therapies against cancer. The first 6 chim...
A Pilot Feasibility Study of an Intervention to Decrease Overtreatment of Low-risk Thyroid Cancer
PROJECT SUMMARY Nearly 90% of patients with low-risk papillary thyroid cancer undergo total thyroidectomy, the treatment option with the greatest morbidity, even though less invasi...
Vascular regulation of fatty acid transport in metastatic tumor outgrowth
Project Summary Tumor metastasis requires supportive microenvironment for outgrowth of disseminated tumor cells. The switch of metastatic cells from dormant to proliferative state...
Optimizing Treatment of Prostate Cancer in Men living with HIV
SUMMARY Cancer is a leading cause of morbidity and mortality among aging people with HIV (PWH) and prostate cancer is now one of the most common cancers among PWH. Despite this, pr...
Consequences of retrotransposition on genome integrity
Project SummaryTransposable elements are a major source of human genetic variation and also contribute to human diseases by causing somatic mutations. The activity of transposition...
HIGHLY SELECTIVE MACROBIOMOLECULAR ISOLATION, SOFT-LANDING AND CHARACTERIZATION USING STRUCTURES FOR LOSSLESS ION MANIPULATIONS
PROJECT SUMMARY/ABSTRACT (30 lines) This project aims to address the current gap in technology for rapid and comprehensive (mass, structure) profiling of biomacromolecules. While h...
SCH: A New Computational Framework for Learning from Imbalanced Biomedical Data
Advances in cancer prevention, diagnosis, and treatment have dramatically improved long-term survival of those diagnosed with breast cancer. However, this success has been tempered...
Emerging role of tumor-derived exosomes in immune modulation and breast cancer health disparity.
Project Abstract Triple-negative breast cancer (TNBC) is an aggressive and invasive breast cancer subtype, accounting for 10-15% of breast cancer diagnoses. TNBC affects African-Am...
Preclinical Validation of Personalized Molecular Assays for Measurable Residual Disease Monitoring in Pediatric AML
PROJECT SUMMARY/ABSTRACT My long-term career goal is to improve outcomes for pediatric patients with acute myeloid leukemia (AML), in part through development of improved modalitie...
Autoantibodies to tumor-derived neoepitopes as biomarkers and immunoPET agents for the early detection of small cell lung cancer
Project Summary/Abstract Small-cell lung cancer (SCLC) kills over 30,000 Americans every year and has a dismal 5-year overall survival rate of less than 7%. However, SCLC outcomes...
Inter-metastatic divergency in small cell lung cancer; implications for the design of future immunotherapies
Abstract Aggressive malignant progression and spreading has limited a clear understanding of the pathophysiology of SCLC. The overarching goal of this “bedside to bench” project is...
Molecular mechanisms and therapeutic targeting of activated NRF2 signaling in MiT/TFE translocation renal cell carcinoma
PROJECT SUMMARY Renal cell carcinoma (RCC) is one of the top ten most common cancers worldwide and is comprised of multiple distinct histologies. One particularly aggressive subtyp...
Understanding and addressing rejection of personalized cancer risk information
PROJECT SUMMARY/ABSTRACT We are entering an era of precision medicine for cancer screening in which screening initiation and maintenance is based on personal risk estimates that in...
Advanced Sample Preparation, Separation and Multiplexed Analysis for In-Depth Proteome Profiling of >1000 Single Cells Per Day
PROJECT SUMMARY/ABSTRACT Cancer tissues exhibit a high degree of phenotypic heterogeneity and plasticity and contain numerous subpopulations of cells in various states. Quantifying...