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20,252 grants found
Showing 3,721 – 3,740 of 20,252 grants
Development and Implementation of Advanced Technologies for Cancer Metabolism Research
PROJECT SUMMARY This proposal requests support for my position as the Director of the Cancer Metabolism Core at Sanford Burnham Prebys Medical Discovery Institute (SBP). The Core i...
Optimizing a Social Connectedness Intervention for Young Adults with Cancer
PROJECT SUMMARY/ABSTRACT Young adults with cancer need tailored behavioral interventions to improve their psychosocial health. Any cancer diagnosis in early adulthood can create de...
Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer
SUMMARY Hormone receptor (HR)+ breast cancer (BC) causes the majority of BC-related deaths in the US, reflecting an unmet need for innovative therapeutic approaches. Indeed, resist...
Targeting off-the-shelf iPSC-derived natural killer cells against solid tumors
During the last 2.5 decades, I have led clinical efforts to develop novel NK cell immunotherapy strategies to treat cancer by advancing lab-based discoveries in the areas of natura...
Tailored prostate cancer screening: addressing USPSTF priority research gaps in a racially-diverse study population
ABSTRACT Screening for prostate cancer (PCa) is highly controversial, as accumulated evidence indicates that widespread, routine prostate-specific antigen (PSA)-based screening red...
Etiologic Heterogeneity Between Molecular Subtypes of Prostate Cancer
PROJECT SUMMARY This proposed project investigates the hypothesis that risk factors for prostate cancer differ by molecular subtype of the tumor. It addresses the conundrum that pr...
Epitranscriptomic control of ROS
Maintenance of the GSH redox cycle is reliant on the activities of selenocysteine-containing GSH metabolizing enzymes which play fundamental roles in chemoprevention. Selenocystein...
SCH: A New Computational Framework for Learning from Imbalanced Biomedical Data
Advances in cancer prevention, diagnosis, and treatment have dramatically improved long-term survival of those diagnosed with breast cancer. However, this success has been tempered...
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
ABSTRACT (R01CA251663) Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanis...
Elucidating mechanisms of therapy response in BRCA2 mutant prostate cancers
ABSTRACT Prostate cancer is the most common non-skin malignancy in men and is projected to cause 34,500 deaths in 2022 in the United States alone. Sequencing studies of advanced le...
Molecular mechanisms and therapeutic targeting of activated NRF2 signaling in MiT/TFE translocation renal cell carcinoma
PROJECT SUMMARY Renal cell carcinoma (RCC) is one of the top ten most common cancers worldwide and is comprised of multiple distinct histologies. One particularly aggressive subtyp...
Functional and Pharmacologic Investigation of the NUP98 Fusion Oncoprotein Interactome
PROJECT SUMMARY Chromosomal translocations involving Nucleoporin 98 (NUP98) are observed in approximately 5% of pediatric acute myeloid leukemia (AML) and are associated with resis...
Targeting off-the-shelf iPSC-derived natural killer cells against solid tumors
During the last 2.5 decades, I have led clinical efforts to develop novel NK cell immunotherapy strategies to treat cancer by advancing lab-based discoveries in the areas of natura...
Optimizing a Social Connectedness Intervention for Young Adults with Cancer
PROJECT SUMMARY/ABSTRACT Young adults with cancer need tailored behavioral interventions to improve their psychosocial health. Any cancer diagnosis in early adulthood can create de...
Nuclear envelope and predisposition to hepatic neoplasia
PROJECT SUMMARY Chronic liver diseases such as nonalcoholic steatohepatitis significantly increase the risk of cirrhosis and hepatocellular carcinoma (HCC). However, the underlying...
Replacing Invasive Cystoscopy with Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
Project Summary There are ~800,000 bladder cancer survivors in the US, making it the fifth most prevalent cancer. This study focuses on the largest group of patients with bladder c...
Tailored prostate cancer screening: addressing USPSTF priority research gaps in a racially-diverse study population
ABSTRACT Screening for prostate cancer (PCa) is highly controversial, as accumulated evidence indicates that widespread, routine prostate-specific antigen (PSA)-based screening red...
ATR: targeting mechanical stress induced EMT and immune suppression in triple negative breast cancer
PROJECT DESCRIPTION/ABSTRACT Therapeutically resistant triple negative breast cancer (TNBC) is characterized by mesenchymal features that facilitate immune evasion and disease prog...
HLA B44 motif neoepitopes in NSCLC: Evaluating their effects on the TME and adding them to established markers in a model to predict durable benefit from PD- 1 inhibition with and without chemotherapy
PROJECT SUMMARY Lung cancer is the leading cause of cancer related deaths in the United States and the World. We recently demonstrated that programmed cell death 1 (PD-1) inhibitor...
A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
PROJECT SUMMARY Protein tyrosine phosphorylation is a common mechanism for relaying essential information in animal cells, and many cancers are driven by aberrant tyrosine phosphor...