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20,252 grants found
Showing 3,701 – 3,720 of 20,252 grants
OR2H1 is an effective target for CAR T cells in human epithelial tumors
ABSTRACT Identifying accessible tumor antigens that are not expressed in vital organs would allow genetic engineering of CAR T cells to avoid dysfunction at tumor beds. We have ide...
The abuse liability, topography and toxicology of ice flavors and non-menthol synthetic cooling agents in e-cigarette products
PROJECT SUMMARY Recently, synthetic cooling agents, WS-3 (N-ethyl-p-menthane-3-carboxamide) and WS-23 (2-isopropyl-N,2,3 trimethylbutyramide), that solely impart a cooling sensatio...
Delineating Functional Immunity via Image-Guided PET
Abstract Immunotherapy has made an enormous impact in the treatment of multiple types of cancer, however most patients fail to benefit and methods to monitor response are lacking....
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
PROJECT SUMMARY: Radiotherapy can be a highly effective treatment for many types of cancers. A major impediment to achieving its full curative promise is the current delivery proce...
Computational approaches to the mechanistic elucidation of the serrated pathway of human colon carcinogenesis
PROJECT SUMMARY This K25 Mentored Quantitative Research Development Award project proposal is to allow the PI, Dr. Marmar Moussa - an experienced Computer Scientist and Bioinformat...
Using natural killer cells to prevent breast cancer metastases
Project Summary/Abstract Most of breast cancer related mortality is related to metastatic disease. While NK cells play an essential role in the control of metastatic breast cancer...
The AVANÇO Research Consortium: A Mozambique/Brazil/Texas Alliance to advance novel and affordable technologies for the prevention and diagnosis of cervical cancer in women living with HIV
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Admin Core
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Project 1
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Project 2
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Shared Resources Core
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Developmental Core
ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Braz...
Neoantigen-specific T cells in a novel cutaneous squamous cell carcinoma model
Abstract: More than one million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed annually in the US and approximately 4% of patients develop metastases and 2% die of...
Studying the role of TERRA in telomere protection and length regulation
PROJECT SUMMARY Telomeres are specialized DNA-protein complex that protect the ends of linear chromosomes. Mammalian telomeres are composed of highly conserved tandem repeat sequen...
Novel Triple-Negative Breast cancer vulnerability governed by PNPT1-mediated RNA decay
PROJECT SUMMARY / ABSTRACT Breast cancer is the most common cancer and the leading cause of cancer death in females. Triple negative breast cancer (TNBC) is a highly aggressive and...
The Role of SKIDA1 in Acute Myeloid Leukemia Initiation and Maintenance
ABSTRACT Chromosomal translocations involving the MLL1 gene often drive infant acute myeloid leukemia (AML). MLL fusion proteins (e.g., MLL-ENL, MLL-AF9, MLL-AF10) activate self-re...
A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
PROJECT SUMMARY Protein tyrosine phosphorylation is a common mechanism for relaying essential information in animal cells, and many cancers are driven by aberrant tyrosine phosphor...
Engineering Protein Modulators of Notch Activation for T-cell immunotherapy
Summary Investigators at the University of Minnesota have teamed up to engineer novel protein activators of the Notch family of cell surface receptors, which are master regulators...
Microfluidic technology to isolate tumoricidal T-cells from peripheral blood
PROJECT SUMMARY Adoptive cell transfer (ACT) using ex vivo expanded anti-tumor T-cells has garnered significant interest due to successes in treating melanoma and other cancers. Th...
Cannabis for Palliative Care in Cancer: A Placebo-controlled Randomized Trial of Full Spectrum Hemp-derived CBD/THC
Project Summary Problems with pain, sleep, and mood are common among individuals diagnosed with cancer (i.e., cancer survivors/patients), and many are turning to cannabis for sympt...