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20,252 grants found
Showing 3,681 – 3,700 of 20,252 grants
HMGB1 in EB-Associated Squamous Cell Carcinoma
Project Summary/Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic disease characterized by chronic wounds and shortened lifespan due to a high incidence...
Elucidating mechanisms of therapy response in BRCA2 mutant prostate cancers
ABSTRACT Prostate cancer is the most common non-skin malignancy in men and is projected to cause 34,500 deaths in 2022 in the United States alone. Sequencing studies of advanced le...
HLA B44 motif neoepitopes in NSCLC: Evaluating their effects on the TME and adding them to established markers in a model to predict durable benefit from PD- 1 inhibition with and without chemotherapy
PROJECT SUMMARY Lung cancer is the leading cause of cancer related deaths in the United States and the World. We recently demonstrated that programmed cell death 1 (PD-1) inhibitor...
FOXA1 regulates cytokine signaling and immune landscape in prostate cancer through ARID1A
Summary Prostate cancer (PCa) is the most commonly diagnosed cancer and the second leading cause of cancer death in American males. Androgen deprivation therapies and androgen rece...
Bispecific Antibody Therapeutics for Neuroblastoma and Diffuse Midline Glioma
PROJECT SUMMARY/ABSTRACT Clearly identified barriers have undermined the promise of immunotherapy for pediatric patients with solid or brain tumors. Most of these tumors lack genet...
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
PROJECT SUMMARY/ABSTRACT Lung cancer is the leading cause of cancer death in the United States, and lung cancer screening has been demonstrated to effectively reduce lung cancer by...
RepurPosed AntiretrOviraL ThErapieS to EliminAte Cervical Cancer (POLESA Trial)
Project Summary/Abstract As the death toll from cervical cancer continues to rise, particularly in low-resource settings, we are in search of more effective approaches to cervical...
Role of the CD44/Hyaluronan axis in mesenchymal prostate cancer
Lineage plasticity has emerged as an important mechanism of treatment resistance in prostate cancer that results into multiple different tumor states. Recent classifications effort...
The Cholangiocarcinoma Conference: Molecular Drivers, Microenvironment, and Precision Medicine
Project Summary/Abstract Cholangiocarcinoma (CCA) is a macro-molecularly diverse hepato-biliary tract malignancy that accounts for approximately 3.0% of gastrointestinal malignanci...
Mitochondrial Regulation of Interferon Response in Melanoma
PROJECT SUMMARY Interferons (IFNs) are central orchestrators of tumor immunity and can elicit both pro-tumor and anti-tumor responses depending on the cancer cell type, the type of...
Vascular regulation of fatty acid transport in metastatic tumor outgrowth
Project Summary Tumor metastasis requires supportive microenvironment for outgrowth of disseminated tumor cells. The switch of metastatic cells from dormant to proliferative state...
University of California and UT Southwestern D-PDTC
PROJECT SUMMARY/ABSTRACT The University of California and the University of Texas Southwestern (UCaTS) Diversity Patient-Derived Xenograft (PDX) Development and Trial Center’s is a...
Admin Core
PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish and characterize a large collection of minority patient-derived cancer xenografts (PDXs) from two canc...
PDX Core
PROJECT SUMMARY/ABSTRACT The primary objectives of the Patient Derived Xenograft (PDX) Core will be to establish and characterize PDXs, and to support the research aims of the two...
Bioinformatics Core
PROJECT SUMMARY The overall objective of the proposed Diversity PDX Development and Testing Center (D-PDTC) is directed at improving cancer precision medicine approaches for gastri...
Advancing gastric cancer precision medicine in Latinos through patient-derived modeling
PROJECT SUMMARY/ASTRACT Gastric cancer (GC) is a leading cause of cancer incidence, mortality, and survival disparities in Latinos, the largest and youngest U.S. minority and the l...
Characterizing treatment responses for common lung cancer (LC) subtypes in Latinos and Asians
SPECIFIC AIMS The purpose of UCaTS Project 2 is to target clinically important genomic markers of early resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant non...
Pilot Projects and Trans-Network Activities
PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) to Redu...
Utilizing Multi-omics to Facilitate Cancer Biology Research
Project Summary As a member of the E. Alejandro Sweet-Cordero laboratory my efforts are directed at executing the computational aspects of the grants, manuscripts, and the general...
Replacing Invasive Cystoscopy with Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
Project Summary There are ~800,000 bladder cancer survivors in the US, making it the fifth most prevalent cancer. This study focuses on the largest group of patients with bladder c...