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20,252 grants found
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SUMOylation disruption is toxic for SS18-SSX-driven synovial sarcoma
Project Summary: Synovial Sarcoma (SS) is driven by the SS18-SSX oncofusion, and SS18-SSX is the only reoccurring mutation in SS. SS normally metastasizes, resulting in a 15-year o...
In vivo Evaluation of Lymph Nodes Using Quantitative Ultrasound
Project Summary This application proposes a collaborative study to be performed by Weill Cornell Medicine (WCM) in New York, NY, as the lead organization in collaboration with GE R...
Investigating the interplay between senescence and T cell immunity
PROJECT SUMMARY/ABSTRACT CANDIDATE: One of my long-standing interests is to understand the mediators of a successful antitumoral T cell response. In this application, I am proposin...
CELL EXPANSION BIOREACTORS FOR ASSAY-READY IMMUNOCOMPETENT PATIENT MODELS
Project Summary/Abstract Although cancer is a leading cause of death globally, oncology drugs have the lowest success rates, cost the most to develop, and constantly show promising...
Integration of non-invasive deep tissue microwave thermometry in the VectRx hyperthermia device in a transgenic liver tumor pig model
Project Summary/Abstract NeoTherma Oncology (NTO/www.neothermaoncology.com) has developed a novel non-invasive medical device that delivers mild hyperthermia (HT) loco-regionally a...
Novel mechanism of induction of tumor pyroptosis by IL-9-secreting Tc9 cells
PROJECT SUMMARY Blood CD8+ T cells can be subdivided into different subsets based on their cytokine section profiles and functions. We have shown that IL-9-secreting CD8+ Tc9 cells...
Rapid, simple, and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy
Abstract While a growing arsenal of drugs is available to treat specific molecular abnormalities across cancers, therapy effectiveness can now be predicted by detecting specific ge...
Decoding the epigenetic landscape that delineates T cell homeostatic proliferation from uncontrolled growth”
PROJECT SUMMARY Epigenetic reinforcement of T cell exhaustion is a well-established barrier limiting multiple modalities of T cell- based immunotherapies for cancer. This proposal...
Fast-kinetics approaches to define direct gene-regulatory functions of MYB in leukemia
Project Summary/Abstract Acute myeloid leukemia (AML) remains a therapeutic challenge and a significant public health burden, necessitating development of novel therapies. The tran...
Defining kinase interaction pathways to enhance anti-cancer efficacy and minimize associated morbidities of kinase inhibitor drugs.
PROJECT SUMMARY The decreased quality of life and increased morbidity due to oncological drugs such as Tyrosine Kinase Inhibitors (TKIs) is a serious and growing general health pro...
Assessment of a Radiomics-Based Computer-Aided Diagnosis Tool for Cancer Risk Stratification of Pulmonary Nodules
PROJECT SUMMARY/ABSTRACT This proposal describes a comprehensive 5-year mentored career development plan with the goal of training the candidate to become a leading independent phy...
Personalized neuroblastoma vaccines
PROJECT SUMMARY This Multiple Principal Investigator (MPI) Project proposal for the Pediatric Immunotherapy Network is focused on high-risk neuroblastoma, a diverse and enigmatic m...
HIGHLY SELECTIVE MACROBIOMOLECULAR ISOLATION, SOFT-LANDING AND CHARACTERIZATION USING STRUCTURES FOR LOSSLESS ION MANIPULATIONS
PROJECT SUMMARY/ABSTRACT (30 lines) This project aims to address the current gap in technology for rapid and comprehensive (mass, structure) profiling of biomacromolecules. While h...
Integrating liquid biopsy-based epigenetic and imaging modalities to evaluate disease response in multiple myeloma
PROJECT SUMMARY Multiple myeloma (MM) affects ~35,000 adult patients in the United States and causes ~12,000 deaths each year. Novel immunomodulatory drugs and effective multidrug...
A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches.
PROJECT SUMMARY The tumor microenvironment (TME) in essentially all epithelial cancers is associated with significant biochemical and structural changes in the extracellular matrix...
Alternatively spliced cell surface proteins as drivers of leukemogenesis and targets for immunotherapy
Project Summary While impressive progress has been made in tumor immunology and clinical application of immunomodulatory agents in solid tumors, we don’t fully understand how to ef...
ATR: targeting mechanical stress induced EMT and immune suppression in triple negative breast cancer
PROJECT DESCRIPTION/ABSTRACT Therapeutically resistant triple negative breast cancer (TNBC) is characterized by mesenchymal features that facilitate immune evasion and disease prog...
Evaluating a remotely delivered, digital health CRC screening intervention among racially diverse patients of a community health center
Project Summary/Abstract Colorectal cancer (CRC) screening is one of the most effective tools to reduce cancer morbidity and mortality. Yet, CRC screening rates at federally qualif...
Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
ABSTRACT Targeted cancer therapy, in the form of tyrosine kinase inhibitors, has been a game changer for patients with cancers driven by activating mutations in genes encoding thes...
Harnessing the repetitive genome for cancer immunotherapy
PROJECT SUMMARYThis KOS proposal describes a five-year career development training program in cancer epigenetics and tumor immunology. Dr. Gabriel Griffin has completed clinical tr...