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20,252 grants found
Showing 3,641 – 3,660 of 20,252 grants
Targeting PP4 to improve ovarian cancer response to immunotherapy
PROJECT SUMMARY/ABSTRACT High-grade serous ovarian cancer has the highest mortality rate of all gynecologic cancers. There is a critical unmet need to identify new therapeutic targ...
Defining a novel subset of metastasis-associated monocytes
Project Summary/Abstract Metastasis is a feature of advanced disease whereby tumor cells spread to distant parts of the body, and is responsible for the vast majority of cancer-rel...
Light-directed therapy of squamous cell head and neck cancer with a novel dual-acting chemotherapeutic.
PROJECT SUMMARY. In this Phase I STTR project, Light Switch Bio will collaborate with Virginia Commonwealth University and the University of Pennsylvania for the early-stage develo...
Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)
PROJECT SUMMARY – OVERALL The partnership center, entitled Partnership to Assess Viral and Immune Landscape Intersections with Oncology (PAVILION) for People Living with HIV Progra...
Administration & Coordinating Core
PROJECT SUMMARY – ADMINISTRATIVE & COORDINATING CORE The Administrative & Coordinating (AC) Core for the Partnership to Assess Viral and Immune Landscape Intersections with...
Project 1: Exploring viral and immunological factors of HPV associated cancers in PLWH and its relation to survival
PROJECT SUMMARY – PROJECT 1 People living with HIV (PLWH) have significantly higher cancer incidence compared to people without HIV for cancers caused by HPV (cervical, vulvar, ana...
Project 2: Novel investigation of Epstein-Barr virus as a potential cause of conjunctival squamous cell carcinoma among people living with HIV in Zimbabwe
PROJECT SUMMARY – PROJECT 2 Conjunctival squamous cell carcinoma (cSCC) is an eye cancer with unknown etiology. cSCC disproportionately impacts Sub-Saharan Africa (SSA), a setting...
Data Management & Statistical Core
PROJECT SUMMARY – DATA MANAGEMENT & STATISTICS CORE The overarching goal of the Data Management & Statistics Core (DMSC) for the Partnership to Assess Viral and Immune Land...
Central Laboratory Core
PROJECT SUMMARY – CENTRAL LABORATORY CORE The overarching goal of the Central Laboratory (CL) Core for the Partnership to Assess Viral and Immune Landscape Intersections with Oncol...
Developmental & Career Enhancement Core
PROJECT SUMMARY – DEVELOPMENTAL CORE The overarching goal of the Developmental Core (DC) for the Partnership to Assess Viral and Immune Landscape Intersections with Oncology for Pe...
Molecular dissection of extrachromosomal DNA formation, development, and evolution
PROJECT SUMMARY / ABSTRACT The devastation wrought by cancer derives primarily from the capacity of tumor cells to evolve. Metastasis, immune evasion, treatment resistance, and eve...
Targeting PP4 to improve ovarian cancer response to immunotherapy
PROJECT SUMMARY/ABSTRACT High-grade serous ovarian cancer has the highest mortality rate of all gynecologic cancers. There is a critical unmet need to identify new therapeutic targ...
Randomized clinical trial to test the efficacy of a smartphone app for smoking cessation for nondaily smokers
Project Summary Nondaily smoking is an increasingly prevalent pattern of smoking with substantial health detriments. Currently, 25% of all U.S. adult smokers are nondaily smokers,...
In vivo Evaluation of Lymph Nodes Using Quantitative Ultrasound
Project Summary This application proposes a collaborative study to be performed by Weill Cornell Medicine (WCM) in New York, NY, as the lead organization in collaboration with GE R...
Signaling basis of senescence-associated secretory phenotype and its implications in epithelial ovarian cancer
Project Summary Cellular senescence is a tumor-suppressive cell growth arrest triggered by inducers such as stand-of-care epithelial ovarian cancer (EOC) chemotherapeutic platinum,...
SUMOylation disruption is toxic for SS18-SSX-driven synovial sarcoma
Project Summary: Synovial Sarcoma (SS) is driven by the SS18-SSX oncofusion, and SS18-SSX is the only reoccurring mutation in SS. SS normally metastasizes, resulting in a 15-year o...
Identification of small molecule inhibitors to exonuclease 1 for breast cancer treatment
ABSTRACT Our overall goal, which is fully responsive to PAR-20-271, is to develop a selective and effective inhibitor of the multi-functional DNA repair enzyme exonuclease 1 (EXO1)...
Investigating the interplay between senescence and T cell immunity
PROJECT SUMMARY/ABSTRACT CANDIDATE: One of my long-standing interests is to understand the mediators of a successful antitumoral T cell response. In this application, I am proposin...
Signaling basis of senescence-associated secretory phenotype and its implications in epithelial ovarian cancer
Project Summary Cellular senescence is a tumor-suppressive cell growth arrest triggered by inducers such as stand-of-care epithelial ovarian cancer (EOC) chemotherapeutic platinum,...
Identification of small molecule inhibitors to exonuclease 1 for breast cancer treatment
ABSTRACT Our overall goal, which is fully responsive to PAR-20-271, is to develop a selective and effective inhibitor of the multi-functional DNA repair enzyme exonuclease 1 (EXO1)...