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20,252 grants found
Showing 3,621 – 3,640 of 20,252 grants
Determinants of immunotherapy response in NASH-Hepatocellular carcinoma
PROJECT SUMMARY / ABSTRACT Hepatocellular carcinoma (HCC) incidence and mortality is increasing in the US and worldwide. Around ~50- 60% of HCC patients will receive systemic thera...
Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Zimbabwe (ZIM-CASCADE)
Project Summary/Abstract Zimbabwe is a resource-constrained country with a high burden of HIV and cervical cancer (CXCA). Zimbabwean women with CXCA present with advanced disease a...
Development of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategies
PROJECT SUMMARY Cancer cachexia (CC) is characterized by unintentional weight loss secondary to adipose and skeletal muscle tissue wasting. It results from a complex interaction be...
Reprogramming Exosomes for Novel Immunotherapy of Triple Negative Breast Cancer
Abstract Triple negative breast cancer (TNBC) accounts for approximately 15-20% of breast cancers and is the most aggressive subtype of breast cancer. Given little efficacy for exi...
Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Zimbabwe (ZIM-CASCADE)
Project Summary/Abstract Zimbabwe is a resource-constrained country with a high burden of HIV and cervical cancer (CXCA). Zimbabwean women with CXCA present with advanced disease a...
Determinants of immunotherapy response in NASH-Hepatocellular carcinoma
PROJECT SUMMARY / ABSTRACT Hepatocellular carcinoma (HCC) incidence and mortality is increasing in the US and worldwide. Around ~50- 60% of HCC patients will receive systemic thera...
The role of tumor cell-of-origin-specific PDL1 on tumorigenesis and tumor progression
ABSTRACT This F31-diversity proposal investigates the role of PDL1 in early melanoma progression using our novel cancer cell-of-origin autochthonous mouse model. Our overarching hy...
A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer
PROJECT SUMMARY This K01 application seeks protected time for mentored research and career development training for Dr. Rosalyn Sayaman, PhD to successfully transition to tenure-tr...
Defining a novel subset of metastasis-associated monocytes
Project Summary/Abstract Metastasis is a feature of advanced disease whereby tumor cells spread to distant parts of the body, and is responsible for the vast majority of cancer-rel...
Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)
PROJECT SUMMARY – OVERALL The partnership center, entitled Partnership to Assess Viral and Immune Landscape Intersections with Oncology (PAVILION) for People Living with HIV Progra...
Administration & Coordinating Core
PROJECT SUMMARY – ADMINISTRATIVE & COORDINATING CORE The Administrative & Coordinating (AC) Core for the Partnership to Assess Viral and Immune Landscape Intersections with...
Project 1: Exploring viral and immunological factors of HPV associated cancers in PLWH and its relation to survival
PROJECT SUMMARY – PROJECT 1 People living with HIV (PLWH) have significantly higher cancer incidence compared to people without HIV for cancers caused by HPV (cervical, vulvar, ana...
Project 2: Novel investigation of Epstein-Barr virus as a potential cause of conjunctival squamous cell carcinoma among people living with HIV in Zimbabwe
PROJECT SUMMARY – PROJECT 2 Conjunctival squamous cell carcinoma (cSCC) is an eye cancer with unknown etiology. cSCC disproportionately impacts Sub-Saharan Africa (SSA), a setting...
Data Management & Statistical Core
PROJECT SUMMARY – DATA MANAGEMENT & STATISTICS CORE The overarching goal of the Data Management & Statistics Core (DMSC) for the Partnership to Assess Viral and Immune Land...
Central Laboratory Core
PROJECT SUMMARY – CENTRAL LABORATORY CORE The overarching goal of the Central Laboratory (CL) Core for the Partnership to Assess Viral and Immune Landscape Intersections with Oncol...
Developmental & Career Enhancement Core
PROJECT SUMMARY – DEVELOPMENTAL CORE The overarching goal of the Developmental Core (DC) for the Partnership to Assess Viral and Immune Landscape Intersections with Oncology for Pe...
Molecular dissection of extrachromosomal DNA formation, development, and evolution
PROJECT SUMMARY / ABSTRACT The devastation wrought by cancer derives primarily from the capacity of tumor cells to evolve. Metastasis, immune evasion, treatment resistance, and eve...
A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer
PROJECT SUMMARY This K01 application seeks protected time for mentored research and career development training for Dr. Rosalyn Sayaman, PhD to successfully transition to tenure-tr...
The role of tumor cell-of-origin-specific PDL1 on tumorigenesis and tumor progression
ABSTRACT This F31-diversity proposal investigates the role of PDL1 in early melanoma progression using our novel cancer cell-of-origin autochthonous mouse model. Our overarching hy...
Randomized clinical trial to test the efficacy of a smartphone app for smoking cessation for nondaily smokers
Project Summary Nondaily smoking is an increasingly prevalent pattern of smoking with substantial health detriments. Currently, 25% of all U.S. adult smokers are nondaily smokers,...