Browse All Grants
20,252 grants found
Showing 3,601 – 3,620 of 20,252 grants
Mechanisms of gene expression regulation in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second deadliest cancer within the next 10-years. Investigations into novel mechanisms of PDAC tr...
Exosomal biomarkers for the early detection of hepatocellular carcinoma
PROJECT SUMMARY: Liver cancer is estimated to afflict 42,230 individuals and result in approximately 30,230 deaths in the US in 2021. The incidence rates for liver cancer have more...
Tumor Antigen Targeted Nanoparticle Therapy for Glioblastoma (GBM)
Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle f...
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention in Uganda
PROJECT SUMMARY Cervical cancer (CC) is the leading cause of cancer-related deaths among women in Uganda, which has one of the world’s highest incidence rates. Evidence-based visua...
Exosomal biomarkers for the early detection of hepatocellular carcinoma
PROJECT SUMMARY: Liver cancer is estimated to afflict 42,230 individuals and result in approximately 30,230 deaths in the US in 2021. The incidence rates for liver cancer have more...
Tumor Antigen Targeted Nanoparticle Therapy for Glioblastoma (GBM)
Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle f...
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention in Uganda
PROJECT SUMMARY Cervical cancer (CC) is the leading cause of cancer-related deaths among women in Uganda, which has one of the world’s highest incidence rates. Evidence-based visua...
Novel DNA cross-linking agents and combination strategies for tumor-specific activation
Project summary/abstract Cancer cells are in a state of increased basal oxidative stress due to their aberrant growth. As a result, cancer cells have elevated levels of reactive ox...
A multimodal approach for precision immuno-oncology in lymphoma treated with CAR-T cells
PROJECT SUMMARY/ABSTRACT Autologous CD19-directed chimeric antigen receptor T-cells (CAR-T) have resulted in extraordinary response rates in relapsing and refractory large B-cell l...
Amyloid-bodies and the Evolution of Malignancies
Diversity Supplement Project Summary The ability of cancer cells to adapt to a wide variety of stress conditions plays a critical role in various physiological facets of tumorigene...
Development of a novel small molecule MDM2 inhibitor for innovative sarcoma treatment
Project summary/abstract This proposal advances the development of a novel therapeutic for p53 wild type sarcomas. Our team has identified a novel MDM2 inhibitor, SA53, with best-i...
Multi-level school-based intervention to improve HPV vaccine uptake and completion in South Africa
PROJECT SUMMARY Human Papillomavirus (HPV) is the most common sexually transmitted infection globally, and is causally linked to cervical, anogenital, and oropharyngeal cancers. HP...
Amyloid-bodies and the Evolution of Malignancies
Amyloid-bodies and the Evolution of Malignancies Project Summary The ability of cancer cells to adapt to a wide variety of stress conditions plays a critical role in various physio...
Rapid Point of Care Test to Screen Human Papillomavirus in Low-Resource Settings
Cervical cancer caused by human papillomavirus (HPV) is the fourth most common cancer among women worldwide, but it is preventable by screening asymptomatic women before HPV infect...
Development of a novel small molecule MDM2 inhibitor for innovative sarcoma treatment
Project summary/abstract This proposal advances the development of a novel therapeutic for p53 wild type sarcomas. Our team has identified a novel MDM2 inhibitor, SA53, with best-i...
A multimodal approach for precision immuno-oncology in lymphoma treated with CAR-T cells
PROJECT SUMMARY/ABSTRACT Autologous CD19-directed chimeric antigen receptor T-cells (CAR-T) have resulted in extraordinary response rates in relapsing and refractory large B-cell l...
Multi-level school-based intervention to improve HPV vaccine uptake and completion in South Africa
PROJECT SUMMARY Human Papillomavirus (HPV) is the most common sexually transmitted infection globally, and is causally linked to cervical, anogenital, and oropharyngeal cancers. HP...
Amyloid-bodies and the Evolution of Malignancies
Amyloid-bodies and the Evolution of Malignancies Project Summary The ability of cancer cells to adapt to a wide variety of stress conditions plays a critical role in various physio...
Development of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategies
PROJECT SUMMARY Cancer cachexia (CC) is characterized by unintentional weight loss secondary to adipose and skeletal muscle tissue wasting. It results from a complex interaction be...
Reprogramming Exosomes for Novel Immunotherapy of Triple Negative Breast Cancer
Abstract Triple negative breast cancer (TNBC) accounts for approximately 15-20% of breast cancers and is the most aggressive subtype of breast cancer. Given little efficacy for exi...