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20,252 grants found
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Understanding and Targeting the R-Loop-Mediated DNA Damage Response at Telomeres
Project Summary Oxidative DNA damage is frequently generated by radiation, chemicals, and endogenous oxygen radicals, contributing to genomic instability during both aging and tumo...
Mechanisms and In Vivo Efficacy of Synergistic Acid Ceramidase and Bcl-2 Inhibition in Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is an aggressive, heterogeneous myeloid malignancy that results in bone marrow failure. The Bcl-2 antagonist/BH3-mimetic, vene...
Novel synthetic lethality strategy for TP53 mutant colorectal cancer
PROJECT SUMMARY/ABSTRACT Genetic alterations in the tumor suppressor p53 gene (TP53) are found in most colorectal adenocarcinomas (CRC) and contributes to poor prognosis. The p53 p...
Therapeutic targeting of master regulators in non-canonical AR driven advanced lethal prostate cancers
PROJECT SUMMARY (ABSTRACT)Androgen receptor (AR) targeted therapies such as abiraterone, enzalutamide, apalutamide, and darolutamide are effective treatments for patients with adva...
Aging in place for older adults with cancer: The role of physical function and home environment
Project Summary and Abstract This award will support Dr. Jensen-Battaglia’s long-term goal of developing the expertise and skills needed to become an independent investigator explo...
Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
PROJECT SUMMARY/ABSTRACT Lymphedema is a major complication after radiation and/or surgery for breast and gynecological cancers. Advancements in surgical techniques mitigate the ri...
A Paradigm to Examine Cancer Disparities: Limited English Proficient Chinese Patients with Thyroid Nodules
PROJECT SUMMARY Asian Americans and Pacific Islanders are the only racial/ethnic group in the United States (US) for whom cancer is the leading cause of death for both sexes. Thus,...
Integrated Imaging Tools for Intercellular Chemokine Signalling
Chemokines and their G-protein coupled receptors (GPCRs) are key mediators of intercellular signaling between cancer cells and multiple stromal cell types. Cancer cell proliferatio...
Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries
The development of scalable, cost-effective antibody libraries for detecting proteins (or other molecules) has greatly lagged the development of methods for detecting (e.g. by hybr...
CAR T cells targeting mesothelin and secreting bispecific antibodies targeting fibroblasts in pancreatic cancer
PROJECT SUMMARY CAR T cell therapy for solid tumors is hindered by a lack of tumor-specific antigens that are safe to target and homogenously expressed throughout the tumor, diffic...
Using Momentary Measures to Understand Physical Activity Adoption and Maintenance among Pacific Islanders in the United States
PROJECT SUMMARY/ABSTRACT Pacific Islanders represent one of the fastest growing racial/ethnic groups in the United States. Pacific Islanders suffer from disparities in a variety of...
Mechanisms of gene expression regulation in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second deadliest cancer within the next 10-years. Investigations into novel mechanisms of PDAC tr...
Engineering Biomaterials to Modulate the Bone Marrow Microenvironment in Multiple Myeloma
PROJECT SUMMARY Multiple myeloma (MM) accounts for ~23% of all hematologic malignancies with a 2.1% of cancer-related deaths in the United States in 2022. Despite tremendous effort...
Mechanisms of gene expression regulation in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second deadliest cancer within the next 10-years. Investigations into novel mechanisms of PDAC tr...
Engineering Biomaterials to Modulate the Bone Marrow Microenvironment in Multiple Myeloma
PROJECT SUMMARY Multiple myeloma (MM) accounts for ~23% of all hematologic malignancies with a 2.1% of cancer-related deaths in the United States in 2022. Despite tremendous effort...
Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries
The development of scalable, cost-effective antibody libraries for detecting proteins (or other molecules) has greatly lagged the development of methods for detecting (e.g. by hybr...
Using Momentary Measures to Understand Physical Activity Adoption and Maintenance among Pacific Islanders in the United States
PROJECT SUMMARY/ABSTRACT Pacific Islanders represent one of the fastest growing racial/ethnic groups in the United States. Pacific Islanders suffer from disparities in a variety of...
CAR T cells targeting mesothelin and secreting bispecific antibodies targeting fibroblasts in pancreatic cancer
PROJECT SUMMARY CAR T cell therapy for solid tumors is hindered by a lack of tumor-specific antigens that are safe to target and homogenously expressed throughout the tumor, diffic...
Integrated Imaging Tools for Intercellular Chemokine Signalling
Chemokines and their G-protein coupled receptors (GPCRs) are key mediators of intercellular signaling between cancer cells and multiple stromal cell types. Cancer cell proliferatio...
A Paradigm to Examine Cancer Disparities: Limited English Proficient Chinese Patients with Thyroid Nodules
PROJECT SUMMARY Asian Americans and Pacific Islanders are the only racial/ethnic group in the United States (US) for whom cancer is the leading cause of death for both sexes. Thus,...