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20,252 grants found
Showing 341 – 360 of 20,252 grants
Enhancement and further development of informatics methods for long-read cancer sequencing
Project Summary Long-read sequencing is rapidly transforming our knowledge of the human genome as well as the approach to uncovering human genetic variation and alterations. In con...
Tumor-cell intrinsic and extrinsic determinants of drug resistance and metastasis
PROJECT SUMMARY Despite advances in cancer therapy, metastatic disease is overwhelmingly fatal and accounts for most cancer- related deaths. Systemic therapies fail to control diss...
Comparative analysis of M-CSF and GM-CSF in human monocyte metabolic reprogramming and differentiation into tumor-associated macrophage-like cells
PROJECT SUMMARY A major component of the tumor microenvironment, tumor-associated macrophages (TAMs) play a critical role in the orchestration of immunosuppression, cancer cell pro...
Promoting Activated Natural Killer (NK) Cell Accumulation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, with a 5-year survival rate of only 12%. Immunotherapy, such as anti-...
Investigating DNA polymerase O in replication stress and cancer therapy
Principal Investigator: Wu, Xiaohua Project Summary Replication stress often occurs when DNA replication is disrupted, leading to DNA double-strand break (DSB) formation. Replicati...
Dissecting intrinsic variability in engineered T Cell immunotherapies
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has revolutionized oncology. Chimeric Antigen Receptor (CAR) T cells in particular have shown dramatic successes in some liquid tumors...
Investigating the regulation of cancer cell death by NFE2L1
Project Summary Resistance to therapy is responsible for 90% of cancer patient mortality. Our understanding of how cancer cells resist therapy-induced death is limited. My goal is...
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
SUMMARY/ABSTRACT Breast cancer is a leading cause of death in the U.S. and a major public health burden as one woman out of eight will receive a diagnosis in her lifetime. Advances...
Ceramide and Cell Metabolism: Defining the Role of Sphingolipids in Modulating Mitochondrial Bioenergetics of Chronic Lymphocytic Leukemia
Project Summary/Abstract Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia and accounts for 20% of leukemia-related deaths annually. In CLL, hyperactivat...
Resolving epigenetic determinants of cellular plasticity programs in non-small cell lung cancer
SUMMARY Pioneering research in cancer biology over the past four decades has uncovered a repertoire of oncogenes and tumor suppressors that initiate and maintain tumorigenesis acro...
Evaluating and Optimizing Novel nSMase2 Inhibitors in the Treatment of Cancers
PROJECT ABSTRACT / SUMMARY: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but many patients fail to respond. Expanding the response to ICIs is a major g...
Determinants of susceptibility to pediatric acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT The role of germline genetic variation and viral infection in development and progression has been studied extensively in adult tumors and autoimmune disea...
The alterations caused by obese extracellular vesicles on colorectal cancer tumor microenvironment
Project Summary Colorectal cancer (CRC) patients with a high body-mas index (BMI) have poor efficacy to chemotherapy, creating an urgent need to design targeted therapy for this gr...
Clinical Translation of a Large Oncosome-Based Prostate Cancer Blood Test
ABSTRACT - The focus of this proposal is on lethal, metastatic prostate cancer (PC). The aim of this study is to develop an innovative, minimally invasive, liquid biopsy assay that...
Investigating the molecular signatures and pathways indicative of air pollution toxicity in lung carcinogenesis using single- and multi-omics analyses of genomics, proteomics, and metabolomics
Project Summary Air pollution is a known environmental risk factor for lung cancer, but the detailed mechanisms driving air pollution-induced carcinogenesis and the key molecular e...
Informatics strategies to improve immune-related adverse event detection in cancer patients
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have drastically improved cancer survival over the past decade, but this survival comes at the cost of a new class of i...
Understanding expression and signaling of sex hormone receptors in brain cancers
PROJECT SUMMARY There is significant evidence of cancer-type specific patterns of sex hormone receptor expression and signaling in many central nervous system (CNS) tumors, often c...
Microbiome-Mitochondrial Interactions Driving Cancer-Induced Cachexia in the Obese State
PROJECT SUMMARY Research: At the time of cancer diagnosis, 40% - 60% of patients are overweight or obese. Despite this, there is a dearth of literature on the impact of weight stat...
Intersection of cytoskeletal regulation with tumor cell metabolism
SUMMARY Pancreatic cancer (PDAC) is particularly lethal, due in part to a resistance to therapies and a high incidence of metastasis. The overall goal of our research program is to...
Defining pro-metastatic drivers in the pancreatic cancer tumor microenvironment
PROJECT ABSTRACT Pancreatic adenocarcinoma (PDAC) is an almost uniformly fatal disease most often diagnosed after the development of metastases. The tumor suppressor gene, TP53, is...