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20,252 grants found
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Project 2: Overcoming GBM RT-resistance
PROJECT SUMMARY/ABSTRACT (Project 2) Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like su...
Core A: Biostatistics and Computational Biology Core
PROJECT SUMMARY/ABSTRACT (CORE A, BIOSTATISTICS AND COMPUTATIONAL BIOLOGY CORE) The Biostatistics and Computational Biology (BCB) Core provides comprehensive professional support t...
PDGF-BB and the metastatic brain microenvironment
PROJECT SUMMARY Recent studies by my group have highlighted the clinical relevance of platelet-derived growth factor-B (PDGFB) secreted by malignant breast epithelial cells and its...
PDGF-BB and the metastatic brain microenvironment
PROJECT SUMMARY Recent studies by my group have highlighted the clinical relevance of platelet-derived growth factor-B (PDGFB) secreted by malignant breast epithelial cells and its...
Chicago Alternative Prevention Study for BReast CAncer in Diverse Populations of High-Risk Women (CAPSBRACA)
PROJECT SUMMARY Risk-stratified breast cancer screening strategies are a paradigm shift from the one-size-fits-all screening approach. Previous age-based screening strategies prove...
Dissecting the intrinsic and extrinsic regulators of prostate cancer dormancy in the bonemicroenvironment.
Project Summary / Abstract………………………………………………………………………………..…. Metastatic prostate cancer (PC) typically manifests in the skeleton. The lesions arise from disseminated tumor cells (D...
Mapping p53 dynamics to cell-fate outcomes in reprogramming and oncogenesis
Project Summary Cell fates are decided as an organism develops. In human development, pluripotent stem cells differentiate into the three layers of ectoderm, mesoderm, and endoderm...
Dissecting the intrinsic and extrinsic regulators of prostate cancer dormancy in the bonemicroenvironment.
Project Summary / Abstract………………………………………………………………………………..…. Metastatic prostate cancer (PC) typically manifests in the skeleton. The lesions arise from disseminated tumor cells (D...
Chicago Alternative Prevention Study for BReast CAncer in Diverse Populations of High-Risk Women (CAPSBRACA)
PROJECT SUMMARY Risk-stratified breast cancer screening strategies are a paradigm shift from the one-size-fits-all screening approach. Previous age-based screening strategies prove...
Mapping p53 dynamics to cell-fate outcomes in reprogramming and oncogenesis
Project Summary Cell fates are decided as an organism develops. In human development, pluripotent stem cells differentiate into the three layers of ectoderm, mesoderm, and endoderm...
Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction
PROJECT SUMMARY/ABSTRACT Lymphedema is a major complication after radiation and/or surgery for breast and gynecological cancers. Advancements in surgical techniques mitigate the ri...
Understanding and Targeting the R-Loop-Mediated DNA Damage Response at Telomeres
Project Summary Oxidative DNA damage is frequently generated by radiation, chemicals, and endogenous oxygen radicals, contributing to genomic instability during both aging and tumo...
Novel synthetic lethality strategy for TP53 mutant colorectal cancer
PROJECT SUMMARY/ABSTRACT Genetic alterations in the tumor suppressor p53 gene (TP53) are found in most colorectal adenocarcinomas (CRC) and contributes to poor prognosis. The p53 p...
Therapeutic targeting of master regulators in non-canonical AR driven advanced lethal prostate cancers
PROJECT SUMMARY (ABSTRACT)Androgen receptor (AR) targeted therapies such as abiraterone, enzalutamide, apalutamide, and darolutamide are effective treatments for patients with adva...
Aging in place for older adults with cancer: The role of physical function and home environment
Project Summary and Abstract This award will support Dr. Jensen-Battaglia’s long-term goal of developing the expertise and skills needed to become an independent investigator explo...
Mechanisms and In Vivo Efficacy of Synergistic Acid Ceramidase and Bcl-2 Inhibition in Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is an aggressive, heterogeneous myeloid malignancy that results in bone marrow failure. The Bcl-2 antagonist/BH3-mimetic, vene...
Chromatin and immune regulation of tumor growth and progression
PROJECT SUMMARY Lung and pancreatic ductal adenocarcinomas are often diagnosed at very late stages of tumor progression when they are most aggressive and difficult to treat. Curren...
Phase 2 clinical trial of a novel T cell therapy following bridging therapy with hypomethylating agents for relapsed AML patients post-stem cell transplant
ABSTRACT This Phase II application will advance MT-401, a novel multi-tumor associated antigen (mTAA)-specific T cell product for the treatment of acute myeloid leukemia (AML) and...
SBIR TOPIC 454: A SOFTWARE TOOL FOR STANDARDIZATION OF RADIOTHERAPY TREATMENT PLANS FOR AI VALIDATION
The goal of this proposal is to create a medical device development tool (MDDT) for use during performance evaluation of artificial intelligence (AI)-based radiotherapy software.Th...
Phase 2 clinical trial of a novel T cell therapy following bridging therapy with hypomethylating agents for relapsed AML patients post-stem cell transplant
ABSTRACT This Phase II application will advance MT-401, a novel multi-tumor associated antigen (mTAA)-specific T cell product for the treatment of acute myeloid leukemia (AML) and...