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Active RESEARCH CENTERS
Project 3: Credentialing CDK 4/6 inhibitors used with radiation as an effective treatment strategy in locally advanced ER+ and TNBC
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT Radiation (RT) therapy remains a mainstay in the treatment of women with breast cancer (BC), but locoregional disease recurrence remains a significant clin...

Active RESEARCH CENTERS
Core A: Biostatistics and Computational Biology Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (CORE A, BIOSTATISTICS AND COMPUTATIONAL BIOLOGY CORE) The Biostatistics and Computational Biology (BCB) Core provides comprehensive professional support t...

Active RESEARCH CENTERS
Core B: Clinical Trials Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (CLINICAL TRIALS CORE) The University of Michigan Rogel Cancer Center Molecularly Targeted Radiosensitization of Locally Advanced Cancers SPORE aims to red...

Active RESEARCH CENTERS
Core C: Radiosensitization Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (Radiosensitization Core) The Radiosensitization Core within this SPORE will provide specialized expertise, instrumentation and technical services to each...

Active RESEARCH CENTERS
Translational Pathology Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY-ABSTRACT (Translational Pathology Core) The overarching mission of the Translational Pathology Core is to collect human tissues associated with clinical information...

Active RESEARCH CENTERS
Developmental Research Program
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY-ABSTRACT (DEVELOPMENTAL RESEARCH PROGRAM) Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As...

Active RESEARCH CENTERS
Project 3: Credentialing CDK 4/6 inhibitors used with radiation as an effective treatment strategy in locally advanced ER+ and TNBC
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT Radiation (RT) therapy remains a mainstay in the treatment of women with breast cancer (BC), but locoregional disease recurrence remains a significant clin...

Active RESEARCH CENTERS
Core B: Clinical Trials Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (CLINICAL TRIALS CORE) The University of Michigan Rogel Cancer Center Molecularly Targeted Radiosensitization of Locally Advanced Cancers SPORE aims to red...

Active RESEARCH CENTERS
Core C: Radiosensitization Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (Radiosensitization Core) The Radiosensitization Core within this SPORE will provide specialized expertise, instrumentation and technical services to each...

Active RESEARCH CENTERS
Translational Pathology Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY-ABSTRACT (Translational Pathology Core) The overarching mission of the Translational Pathology Core is to collect human tissues associated with clinical information...

Active RESEARCH CENTERS
Developmental Research Program
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY-ABSTRACT (DEVELOPMENTAL RESEARCH PROGRAM) Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As...

Active RESEARCH CENTERS
Career Enhancement Program
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (CAREER ENHANCEMENT PROGRAM) The Career Enhancement Program (CEP) of the Molecularly Targeted Radiosensitization of Locally Advanced Cancers SPORE at the U...

Active RESEARCH CENTERS
Molecularly Targeted Radiosensitization of Locally Advanced Cancers
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY (OVERALL) Cancer cannot be cured unless the primary tumor is cured. For patients with locally advanced or unresectable disease for whom initial surgery is not an op...

$20.66M
USD
Active RESEARCH CENTERS
Administrative Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

Project Abstract-Summary (Administrative Core) The Administrative Core of the University of Michigan Molecularly Targeted Radiosensitization of Locally Advanced Cancers SPORE (Radi...

Active RESEARCH CENTERS
Project 1: Combining PARP inhibition with radiation to sensitize HR proficient pancreatic cancers to immunotherapy
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (PROJECT 1) We discovered that inhibitors of the DDR (DNA damage response) enhance radiation-induced T1IFN (Type I interferon)-mediated innate immunity and...

Active RESEARCH CENTERS
Project 2: Overcoming GBM RT-resistance
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (Project 2) Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like su...

Active RESEARCH CENTERS
Career Enhancement Program
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (CAREER ENHANCEMENT PROGRAM) The Career Enhancement Program (CEP) of the Molecularly Targeted Radiosensitization of Locally Advanced Cancers SPORE at the U...

Active RESEARCH CENTERS
Molecularly Targeted Radiosensitization of Locally Advanced Cancers
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY (OVERALL) Cancer cannot be cured unless the primary tumor is cured. For patients with locally advanced or unresectable disease for whom initial surgery is not an op...

$19.46M
USD
Active RESEARCH CENTERS
Administrative Core
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

Project Abstract-Summary (Administrative Core) The Administrative Core of the University of Michigan Molecularly Targeted Radiosensitization of Locally Advanced Cancers SPORE (Radi...

Active RESEARCH CENTERS
Project 1: Combining PARP inhibition with radiation to sensitize HR proficient pancreatic cancers to immunotherapy
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2023 – 2028

PROJECT SUMMARY/ABSTRACT (PROJECT 1) We discovered that inhibitors of the DDR (DNA damage response) enhance radiation-induced T1IFN (Type I interferon)-mediated innate immunity and...