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20,252 grants found
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p27pTpT drives cancer-promoting inflammation and shapes the tumor microenvironment (TME) toward a more tumor-permissive state in vivo
Breast Cancer (BC) is the leading cause of cancer-related death in women. Therapy resistance is a major limiting factor. Therefore, the long-term goal of this grant is to elucidate...
p27pTpT drives cancer-promoting inflammation and shapes the tumor microenvironment (TME) toward a more tumor-permissive state in vivo
Breast Cancer (BC) is the leading cause of cancer-related death in women. Therapy resistance is a major limiting factor. Therefore, the long-term goal of this grant is to elucidate...
Computer-Aided Triage of Body CT Scans with Deep Learning
PROJECT SUMMARY / ABSTRACT Computed tomography (CT) imaging for the body can result in thousands of images spanning many organs and myriad possible diseases. With growing patient l...
The Immunomodulatory Effects of Nrf2 Activation on Macrophages in the Lung Tumor Microenvironment
Project Summary There is a critical need for the development of new therapies for lung cancer, as current treatments are ineffective and the five-year survival rate remains below 2...
Computer-Aided Triage of Body CT Scans with Deep Learning
PROJECT SUMMARY / ABSTRACT Computed tomography (CT) imaging for the body can result in thousands of images spanning many organs and myriad possible diseases. With growing patient l...
Targeting chemotherapy resistant high grade serous ovarian cancer
Project Summary Of all gynecologic cancers, ovarian cancer (OCa) has the highest mortality rate in the US. Patients with serous OCa respond to current treatments, including cytotox...
Targeting chemotherapy resistant high grade serous ovarian cancer
Project Summary Of all gynecologic cancers, ovarian cancer (OCa) has the highest mortality rate in the US. Patients with serous OCa respond to current treatments, including cytotox...
Health-related quality of life and patient reported outcomes among people living with HIV and cancer
PROJECT SUMMARY Advances in HIV treatment have improved life expectancy among people with HIV (PWH). As PWH live longer, they are at increased risk for cancer and cancer-related mo...
The Immunomodulatory Effects of Nrf2 Activation on Macrophages in the Lung Tumor Microenvironment
Project Summary There is a critical need for the development of new therapies for lung cancer, as current treatments are ineffective and the five-year survival rate remains below 2...
A novel, one stop, affordable, point of care and artificial intelligence supported system of screening, triage and treatment selection for cervical cancer and precancer in the LMICs
EASTER Application identifier 1161104 Summary statement Artificial intelligence (AI) has penetrated many scientific disciplines, including medicine. AI is fast gaining reputation a...
Engineered Nanoformulation for Immune-modulation in Cancer
Expression of immune check point (ICP) molecules on tumor cells and the host immune cells, especially T-cells present in the tumor milieu, negatively impact the cancer treatment ou...
Optimizing the Efficacy and Safety of CD33-Targeted Immunotherapy for Acute Myeloid Leukemia and Other CD33+ Disorders
ABSTRACT Therapies targeting CD33 have long been pursued to improve outcomes in acute myeloid leukemia (AML). Longer survival with the CD33 monoclonal antibody (mAb)-drug conjugate...
Research Specialist in Cancer Genomics to Integrate Basic Research and Clinical Data
ABSTRACT Human cancers are complex diseases with pathobiology driven by heritable genetics, environmental exposures, somatic genomic and epigenomic alterations, and contributions f...
Development of abuse liability-based tobacco tax proposals: Experimental impact on tobacco-related socioeconomic cancer health disparities
PROJECT SUMMARY/ABSTRACT Nearly 30% of all cancer deaths are attributable to tobacco use. Tobacco taxes have positively impacted the prevalence of tobacco use and subsequently the...
A novel AR degrader in castrate-resistant prostate cancer
Androgen receptor (AR) plays a critical role in prostate cancer (PCa) in all stages. While a majority of patients with PCa initially respond to androgen deprivation and/or anti-and...
Georgia Consortium to Eliminate Cervical Cancer in Women Living with HIV (GaCECC-WLWH)
PROJECT SUMMARY/ABSTRACT Women living with HIV (WLWH) have a substantially increased risk for cervical cancer when compared to women without HIV infection (1). Georgia has the seco...
Reflectance confocal microscopy-optical coherence tomography (RCM-OCT) imaging of oral lesions: Toward an affordable device and approach for developing countries
High rates of incidence and prevalence of oral cancers occur in 15-20 developing low-and-middle income countries (LMICs) in Asia and Africa. Visual clinical examination followed by...
Georgia Consortium to Eliminate Cervical Cancer in Women Living with HIV (GaCECC-WLWH)
PROJECT SUMMARY/ABSTRACT Women living with HIV (WLWH) have a substantially increased risk for cervical cancer when compared to women without HIV infection (1). Georgia has the seco...
Optimizing the Efficacy and Safety of CD33-Targeted Immunotherapy for Acute Myeloid Leukemia and Other CD33+ Disorders
ABSTRACT Therapies targeting CD33 have long been pursued to improve outcomes in acute myeloid leukemia (AML). Longer survival with the CD33 monoclonal antibody (mAb)-drug conjugate...
A novel, one stop, affordable, point of care and artificial intelligence supported system of screening, triage and treatment selection for cervical cancer and precancer in the LMICs
EASTER Application identifier 1161104 Summary statement Artificial intelligence (AI) has penetrated many scientific disciplines, including medicine. AI is fast gaining reputation a...