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20,252 grants found
Showing 3,461 – 3,480 of 20,252 grants
Admin-Core-001
PROJECT SUMMARY The Administrative Core of the Washington University/University of Oklahoma/University of New Mexico Specialized Program of Research Excellence (SPORE) Route 66 End...
Administrative Core
PROJECT SUMMARY The Administrative Core of the Washington University/University of Oklahoma/University of New Mexico Specialized Program of Research Excellence (SPORE) Route 66 End...
Delineating the mechanisms by which tumor immunity multicellular networks shape T cell state
T cells are greatly impacted by their environment, interacting with neighboring cells that may attract, stimulate, inhibit, and otherwise alter T cell activity. Examining multicell...
Route 66 Endometrial Cancer SPORE
PROJECT SUMMARY The Route 66 Endometrial Cancer SPORE brings together interactive research teams from three institutions to create a dynamic translational research program aimed at...
Administrative Core
PROJECT SUMMARY The Administrative Core of the Washington University/University of Oklahoma/University of New Mexico Specialized Program of Research Excellence (SPORE) Route 66 End...
Project 1: Targeting HSPA Proteins in Advanced and Recurrent Endometrial Cancer Therapy
PROJECT SUMMARY The incidence and mortality of endometrial cancer has increased over the past few decades, and is predicted to continue rising. There is significant need for improv...
Project 2: Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
PROJECT SUMMARY The prognosis for the aggressive histologies in uterine cancer patients is low. This is likely due to lack of identification of pathways specific to uterine serous...
Project 3: Primary Prevention and Uterine Preservation in Premenopausal Women with Obesity and Endometrial Hyperplasia/Cancer
PROJECT SUMMARY/ ABSTRACT Up to 90% of the ~65,000 women diagnosed with endometrial cancer each year in the U.S. are overweight or obese, and up to 60% of endometrial cancer cases...
Core 1: Biostatistics and Bioinformatics Core
PROJECT SUMMARY The Biostatistics and Bioinformatics Core facility provides state-of-the-art statistical support for all Route 66 Endometrial Cancer SPORE investigators and project...
Core 2: Biospecimen, Metabolomics, and Pathology Core
PROJECT SUMMARY/ABSTRACT The goal of the Biospecimen, Metabolomics, and Pathology Core (BMP Core) is to create a federated, multi- institutional resource to provide high-quality, c...
Career Enhancement Program
PROJECT SUMMARYThe goal of the Route 66 Endometrial Cancer SPORE Career Enhancement Program (CEP) is to recruit and support early career and established investigators in translatio...
Role of necrosis in the evolution of highly metastatic and chemo-resistant breast cancers
High-grade, fast-growing breast cancers often display necrosis, usually within the tumor interior, where perfusion, nutrients, and oxygen are limited. Recent studies indicate that...
Pre-clinical testing of low intensity ultrasound as novel strategy to prevent paclitaxel-induced hair follicle damage in a humanized mouse model of chemotherapy-induced alopecia
PROJECT SUMMARY Taxanes like paclitaxel (PTX) are highly effective anti-microtubule agents frequently used in cancer therapy, but they also cause major dose-limiting skin toxicity....
Developmental Research Program
PROJECT SUMMARY/ ABSTRACT The overall goals of the Route 66 Endometrial Cancer SPORE Developmental Research Program (DRP) are to support innovative, early-stage research in endomet...
Route 66 Endometrial Cancer SPORE
PROJECT SUMMARY The Route 66 Endometrial Cancer SPORE brings together interactive research teams from three institutions to create a dynamic translational research program aimed at...
PROMINENT: Discovering the molecular signatures of cancer PROMotion to INform prevENTion
No Abstract
Route 66 Endometrial Cancer SPORE
PROJECT SUMMARY The Route 66 Endometrial Cancer SPORE brings together interactive research teams from three institutions to create a dynamic translational research program aimed at...
The Thromboxane-Prostanoid Receptor in Radiation-Induced Pulmonary Fibrosis
Project Summary: Radiation induced lung injury is a crucial dose-limiting factor in patients receiving thoracic radiotherapy, affecting a significant proportion of patients even wi...
Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training
Project Summary Women aged 50+ years comprise 77% of breast cancer diagnoses and 93% of all breast cancer survivors (BCS). Unfortunately, the interaction between cancer treatment a...
The telomere biomarker as a tool to inform decision-making for aggressive salvage therapy in men with rising PSA post prostatectomy
Men with biochemical recurrence after prostatectomy receiving salvage radiation (RT) may benefit from added anti-androgen therapy (AAT) by decreasing their likelihood of progressin...