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20,252 grants found
Showing 3,441 – 3,460 of 20,252 grants
Project 3: Targeting Stress-induced MK2 as Novel Strategy in Pancreatic Cancer
PROJECT SUMMARY We propose a phase 1 clinical trial to test the safety and preliminary efficacy of a new therapeutic strategy that aims at augmenting the efficacy of standard chemo...
Core B: Biospecimen Core
PROJECT SUMMARY The controlled collection and processing of clinical specimens from patients with pancreatic ductal adenocarcinoma (PDAC) is a critical activity for an efficient an...
Core C: Biostatistical and Bioinformatics Core
PROJECT SUMMARY The Biostatistics and Bioinformatics Core (Core C) facility will provide study design, pipeline development, data management, and computational support for all SPOR...
Developmental Research Program
PROJECT SUMMARY The goal of the SPORE in Pancreatic Cancer Developmental Research Program (DRP) is to recruit and support developmental research projects in pancreatic cancer for f...
Career Enhancement Program
PROJECT SUMMARY The SPORE in Pancreatic Cancer Career Enhancement Program (CEP) aims to recruit and support new independent investigators in translational pancreatic cancer researc...
SBIR PHASE II, TOPIC 420: INTEGRATED PLATFORM AND CONSUMABLES FOR ROBUST, SENSITIVE AND HIGH-THROUGHPUT SINGLE-CELL PROTEOMICS
Mass spectrometry-based proteomics can now quantify up to thousands of proteins from trace samples including single cells, yet such studies require highly specialized, custom-built...
Mitochondrial NAD+ in Acute Myeloid Leukemias
PROJECT SUMMARY Targeting mitochondrial metabolism is an active area of research in Acute Myeloid Leukemia (AML). The cumulative data indicate that AML cells have heightened mitoch...
The Development and Psychometric Evaluation of the SIRS: A Social Isolation Risk Scale for Survivors of Head and Neck Cancer
Head and neck cancer (HNC) survivors have unique survivorship challenges (e.g., facial disfigurement), which often lead to social isolation. To address social isolation and prevent...
Mitochondrial NAD+ in Acute Myeloid Leukemias
PROJECT SUMMARY Targeting mitochondrial metabolism is an active area of research in Acute Myeloid Leukemia (AML). The cumulative data indicate that AML cells have heightened mitoch...
Route 66 Endometrial Cancer SPORE
PROJECT SUMMARY The Route 66 Endometrial Cancer SPORE brings together interactive research teams from three institutions to create a dynamic translational research program aimed at...
Administrative Core
PROJECT SUMMARY The Administrative Core of the Washington University/University of Oklahoma/University of New Mexico Specialized Program of Research Excellence (SPORE) Route 66 End...
Project 1: Targeting HSPA Proteins in Advanced and Recurrent Endometrial Cancer Therapy
PROJECT SUMMARY The incidence and mortality of endometrial cancer has increased over the past few decades, and is predicted to continue rising. There is significant need for improv...
Project 2: Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
PROJECT SUMMARY The prognosis for the aggressive histologies in uterine cancer patients is low. This is likely due to lack of identification of pathways specific to uterine serous...
Project 3: Primary Prevention and Uterine Preservation in Premenopausal Women with Obesity and Endometrial Hyperplasia/Cancer
PROJECT SUMMARY/ ABSTRACT Up to 90% of the ~65,000 women diagnosed with endometrial cancer each year in the U.S. are overweight or obese, and up to 60% of endometrial cancer cases...
Core 1: Biostatistics and Bioinformatics Core
PROJECT SUMMARY The Biostatistics and Bioinformatics Core facility provides state-of-the-art statistical support for all Route 66 Endometrial Cancer SPORE investigators and project...
Core 2: Biospecimen, Metabolomics, and Pathology Core
PROJECT SUMMARY/ABSTRACT The goal of the Biospecimen, Metabolomics, and Pathology Core (BMP Core) is to create a federated, multi- institutional resource to provide high-quality, c...
Developmental Research Program
PROJECT SUMMARY/ ABSTRACT The overall goals of the Route 66 Endometrial Cancer SPORE Developmental Research Program (DRP) are to support innovative, early-stage research in endomet...
Career Enhancement Program
PROJECT SUMMARYThe goal of the Route 66 Endometrial Cancer SPORE Career Enhancement Program (CEP) is to recruit and support early career and established investigators in translatio...
Role of necrosis in the evolution of highly metastatic and chemo-resistant breast cancers
High-grade, fast-growing breast cancers often display necrosis, usually within the tumor interior, where perfusion, nutrients, and oxygen are limited. Recent studies indicate that...
Delineating the mechanisms by which tumor immunity multicellular networks shape T cell state
T cells are greatly impacted by their environment, interacting with neighboring cells that may attract, stimulate, inhibit, and otherwise alter T cell activity. Examining multicell...