Browse All Grants
20,252 grants found
Showing 3,381 – 3,400 of 20,252 grants
Uncovering ATR signaling networks underlying chemotherapeutic synergies
PROJECT SUMMARY/ABSTRACT The DNA damage sensor kinase ATR is essential for human cell viability and plays a crucial role in cell tolerance to DNA replication stress1–3. Cancer cell...
Tri-Signal Artificial Antigen Presenting Cells for Cancer Immunotherapy
PROJECT SUMMARY Adoptive cellular therapy (ACT) treatments, in which cancer patients are infused with autologous tumor- specific cytotoxic (CD8+) T cells expanded and activated ex...
Targeting the Immunosuppressive Tumor Microenvironment for Colorectal Cancer Treatment
Project Summary/Abstract Despite notable improvements in colorectal cancer (CRC) treatment, the prognosis of patients with metastatic CRC (mCRC) remains poor, with a median overall...
Modeling and Dissecting Epigenetic Drivers of Gliomagenesis
PROJECT SUMMARY Diffuse gliomas are incurable brain tumors despite aggressive therapies 1–4. Understanding the mechanisms that initiate gliomas is a critical step towards improving...
Enhancing Precision of Pediatric Cancer Molecular Targets by Aggregating CCDI Genomic Data to Pediatric Cancer Knowledgebase
ABSTRACT Knowledge about molecular targets, including those affected by genetic abnormality, has become increasingly critical for childhood cancer precision oncology. To facilitate...
Integrated delivery of cancer control interventions for adolescents and young adults living with HIV in Zambia
PROJECT SUMMARY/ABSTRACT Zambia is a global epicenter for HIV with a large number of adolescents and young adults living with HIV (AYAHIV). Compared with their uninfected peers, AY...
Project 4:Targeting M2-like Macrophages and MDSC with Myelolytic-Virotherapy
Abstract - Project 4: Cure rates for pediatric patients with relapsed or metastatic solid tumors remain unacceptably low. Cancer immunotherapies hold great promise, but scores of d...
Project 1
PROJECT SUMMARY: Children with NUP98-rearranged acute leukemias demonstrate a poor response to conventional therapy and are associated a high rate of relapsed disease and poor over...
Southern Environmental Health Study
SUMMARY Approximately 80% of human cancers are caused by adverse environmental exposures, unhealthy lifestyles and/or their interactions with host susceptibility factors. Previous...
Illuminating the evolutionary history of colorectal cancer metastasis: basic principles and clinical applications
Background. Metastasis to vital organs is the cause of death in a large majority of cancer patients. Although it is of eminent clinical importance to understand how systemic diseas...
South Carolina Cancer Disparities Research Center (SC CADRE)
SUMMARY . ABSTRACT N/A. Description is included in the original proposal.
South Carolina Cancer Disparities Research Center (SC CaDRe)
Project Summary & Abstract N/A Description is included in the original proposal
Project 1 - Molecular Genetics of Human Papillomavirus Infection and Oncogenesis
PROJECT 1 − SUMMARY/ABSTRACT A subset of human papillomaviruses (HPVs) cause 5% of human cancers including the majority of cervical cancers. Over the current funding period, we dis...
Project 3 - Characterizing the Amplification Factories of Epstein-Barr Virus and Kaposi's Sarcoma-associated Herpesvirus
PROJECT 3 − SUMMARY/ABSTRACT Epstein-Barr Virus (EBV) and Kaposi's Sarcoma Herpesvirus (KSHV) cause lymphomas, carcinomas, and sarcomas in people across the world. No specific...
Project 4 - Controlling the Latent-to-Lytic Switch in Epstein-Barr Virus
PROJECT 4 – PROJECT SUMMARY/ABSTRACT Epstein-Barr virus (EBV) is associated with 2% of human cancers, including a variety of B-cell lymphomas, nasopharyngeal carcinomas, and some g...
Project 5 - EBV Drivers of Oncogenesis and Novel Therapies
PROJECT 5 – PROJECT SUMMARY/ABSTRACT Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro results in their growth transformation; however, in vivo, the growth of EBV...
Singer SPORE Supplement
ABSTRACT The long-term goal of the SPORE in Soft Tissue Sarcoma is to reduce the morbidity and mortality from soft tissue sarcoma by developing therapies targeted to specific molec...
Text2QuitPLUS: A Text-based Smoking Cessation Intervention for Sexual and Gender Minority Groups
ABSTRACT Smoking among sexual and gender minority (SGM) groups, which include lesbian, gay, bisexual, and transgender (LGBT) individuals, have been reported from different sources...
Colorado Head and Neck Cancer SPORE
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 23-059. Sinonasal carcinoma (SC) is an important head and ne...
Project 4:Targeting M2-like Macrophages and MDSC with Myelolytic-Virotherapy
Abstract - Project 4: Cure rates for pediatric patients with relapsed or metastatic solid tumors remain unacceptably low. Cancer immunotherapies hold great promise, but scores of d...