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20,252 grants found
Showing 321 – 340 of 20,252 grants
Leading NCI Clinical Trials Network research nationally and at the City of Hope Comprehensive Cancer Center
PROJECT SUMMARY This R50 application will support the activities of Dr. Alex Herrera as a Research Specialist (Clinician Scientist) promoting and supporting National Cancer Institu...
Development of Tailored, Multilevel Cervical Cancer Interventions for Ethnically Diverse Black Women
PROJECT SUMMARY While approximately 85% of Black women report being screened for Cervical Cancer (CC) compared with about 83% of White women, Black women have a higher incidence of...
Parents helping Parents for Youth Vaping Cessation (PhP-VX)
Project Summary Youth electronic cigarette (e-cigarette) use is a public health concern. Many youths are eager to quit vaping, and our prior study estimated that 67.3% of adolescen...
Comparing post-test genetic counseling with and without pre-test counseling: The evolving landscape for optimizing cancer care
Project Summary (Abstract) The number of people who qualify for hereditary breast and ovarian cancer (HBOC) genetic testing has outpaced the number of genetic counselors qualified...
Data-driven Diagnostics using Multimodal- AI Assisted Approaches for Early Cancer Detection
Project Summary: The vast majority (90%) of cancers are epithelial in nature, and oral squamous cell carcinoma (OSCC) accounts for a portion of these cases by afflicting 744,884 pe...
The interface of neurons and cancer
Project Summary The F99 portion of this proposal investigates the role of the brain enriched E3 ubiquitin ligase TRIM9 in melanoma progression. The K00 portion of this proposal inv...
Identifying and Targeting Drivers of Impaired Translation in Tumor-infiltrating CD8+ T-cells.
PROJECT SUMMARY/ ABSTRACT Immune checkpoint blockade (ICB), aimed at reinvigorating immune cells such as T-cells, has exhibited clinical success in a subset of patients yet fails t...
Virtual Digital Histopathology with Explainable Deep Learning for Prostate Cancer Diagnosis
Project Summary Adoption of digital histopathology has increased demands for gigapixel image analysis tools and methods for clinical applications. Integration of deep learning algo...
Harnessing Extracellular Vesicles to Overcome Radiation Resistance in Pediatric Diffuse Midline Glioma
PROJECT SUMMARY Diffuse midline gliomas with H3K27M alteration (DMG-H3K27M) are the leading cause of pediatric brain tumor-associated deaths. All DMG-H3K27M becomes resistant to ra...
Human papillomavirus mRNA detection for assessing cervical cancer risk in resource-limited settings
ABSTRACT Cervical cancer is highly preventable with early detection and treatment, but due to lack of accessible early screening options, incidence and mortality are still very hig...
An In-depth Examination of Psychological Distress among Black Breast Cancer Survivors
PROJECT SUMMARY Psychological distress is an important component of cancer care, and can adversely affect treatment compliance, quality of life and survival. Data about psychologic...
Dissecting the genetic basis of cancer immune evasion in squamous cell carcinoma
PROJECT SUMMARY/ABSTRACT While immunotherapies have revolutionized cancer treatment, a subset of patients, particularly those with squamous cell carcinomas (SCCs) found in the skin...
Informing mechanistic rules of agent-based models with single-cell multi-omics
PROJECT SUMMARY Cancer is driven by interactions between diverse cell types and their tissue microenvironment. Emerging single- cell and spatial transcriptomic systems are mapping...
Investigating microphthalmia-associated transcription factor (MITF) and growth factors as initiators of melanoma
ABSTRACT Melanoma is the deadliest type of skin cancer. It can be cured with surgical resection if detected early, so advancing methods of prevention and early detection for melano...
Elucidating racial and ethnic differences in functional effects of the vaginal microbiome in ovarian cancer
ABSTRACT. This K22 proposal aims to enhance the applicant’s prior quantitative training with a combination of formal coursework and informal guidance to transition to independence...
The role of hexokinase 2 in liver fibrosis and NASH-induced HCC
Hepatic fibrosis is a major cause of mortality in patients with non-alcoholic steatohepatitis (NASH). Hepatic fibrosis also plays a major role in the development of hepatocellular...
Development of Tunable Microenvironment-Responsive CAR T Cells Using Synthetic Gene Circuits to Enhance Potency and Safety
PROJECT SUMMARY Ovarian cancer is the most lethal malignancy of the female reproductive system, and despite advances in understanding of the disease, therapeutic options for treati...
Tumor-Immune Interactions and Cisplatin Resistance in Bladder Cancer
Project summary This K08 Career Development Award proposal for Dr. Filipe de Carvalho describes a research plan and career development program leading up to an academic career as a...
Implementation of a Community-Based Cancer Prevention Intervention with a Marginalized Population Experiencing Food Insecurity
PROJECT SUMMARY/ABSTRACT Food insecurity is a strong mediator in the relationship between poverty and breast cancer mortality in the United States. National data has identified adu...
Optimization of anal cancer screening for people with HIV using genomic methods
PROJECT SUMMARY Anal cancer represents approximately ~10% of all solid cancers among people with HIV (PWH) and is responsible for ~4% of all mortality in this group, representing a...