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20,252 grants found
Showing 3,361 – 3,380 of 20,252 grants
Investigating tRNA biology as a prognostic and oncogenic feature in pancreatic adenocarcinoma
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is uniquely difficult to treat due to late diagnosis and limited medical management options for a majority of patients. This...
Targeting Nonsense-Mediated RNA Decay in Splicing Factor Mutant Myeloid Malignancies.
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by peripheral blood cytopenias, bone marrow dysplasia, and ineff...
The role of DPF2 stability in SMARCB1-deficient cancers
PROJECT SUMMARY Rhabdoid tumors are one of the most aggressive and lethal cancers in pediatric oncology with overall 5-year survival rates of ~20-25%. Loss of SMARCB1 is the primar...
Examining the impact of laboratory housing temperature on murine CD28 and the response to anti-PD-1
Project Abstract/Summary For decades, animals in biomedical research have yielded significant scientific and medical breakthroughs by generating the essential preclinical data that...
Machine Learning and Radiomics Techniques for Analysis of Daily MRI in Glioblastoma Patients
PROJECT SUMMARY Glioblastoma is the most common primary brain cancer worldwide. Novel treatment strategies are urgently needed since glioblastoma is nearly universally fatal with a...
Targeting Metabolic Reprogramming in ER+ Breast Cancer
Project Summary: Adjuvant endocrine therapies are effective in treating estrogen receptor-positive (ER+) breast cancer, but drug-tolerant persister cancer cells (DTPs) contribute t...
The roles of AP-1 pathway activation in NK cell development and exhaustion programming in AML
PROJECT SUMMARY/ABSTRACT The 5-year overall survival rate for acute myeloid leukemia (AML) is less than 35%, making it the most fatal leukemia in adults. Natural killer (NK) cells...
RNA Processing in Cancer Conference: From Bench to Bedside
SUMMARY Alterations in RNA processing have recently emerged as a new cancer hallmark and a promising target for cancer therapies. The fields of cancer and RNA biology have traditio...
Identifying genetic vulnerabilities in KIAA1549-BRAF mutant pediatric low-grade gliomas
Project Summary: Pediatric low-grade gliomas (pLGGs) typically harbor only a single oncogenic driver event which almost universally result in MAPK pathway activation. The most freq...
Fibroblasts in the establishment of the liver pre-metastatic niche
PROJECT SUMMARY Postpartum breast cancer (PPBC), defined as breast cancer diagnosed within 10-years after a women's last childbirth, accounts for 50% of young women's bre...
STAKEHOLDER ENGAGEMENT AND OUTREACH SUPPORT FOR HEALTH BEHAVIOR CHANGE AND CANCER CONTROL RESOURCES
The National Cancer Institute (NCI) has created smoking cessation and other behavioral health services for multiple population groups and diverse audiences. NCI needs to provide su...
Project 4: Off-the-shelf engineered cord blood-derived natural killer cells for the treatment acute lymphoblastic leukemia
Summary: The past several years have seen tremendous advances in the engineering of immune effector cells as therapy for cancer. However, chimeric antigen receptor (CAR)-modified T...
Understanding the role of β2AR-signaling on ILC2 differentiation/plasticity and its implications in cancer progression
Project Summary / Abstract: In preclinical models, norepinephrine released by sympathetic nerves during chronic stress have been demonstrated to promote an immunosuppressive tumor...
THIS PURCHASE ORDER INCLUDES SERVICES TO OBTAIN ANNUAL POPULATION ESTIMATES FOR STATE, COUNTIES AND CENSUS TRACTS BASED ON THE COUNTS PRODUCED BY THE US CENSUS BUREAU. THESE SPECIFICALLY-DEVELOPED EST
THIS PURCHASE ORDER INCLUDES SERVICES TO OBTAIN ANNUAL POPULATION ESTIMATES FOR STATE, COUNTIES AND CENSUS TRACTS BASED ON THE COUNTS PRODUCED BY THE US CENSUS BUREAU.SPECIFICALLY-...
Posttranslational Regulation of FOXA1 in Breast Cancer
Project Summary Breast cancer is the second leading cause of cancer mortality in women and nearly 75% of all breast tumors express estrogen receptor alpha (ER) at the time of diagn...
STING-dependent Intestinal Regeneration upon Radiation Injury
Summary The intestinal epithelium is the fast renewing adult tissue and highly sensitive to genotoxic agents such as radiation and chemotherapy. Acute gastrointestinal (GI) injury...
Elucidation of the molecular mechanisms of the RBM15-MKL1 fusion protein in acute megakaryoblastic leukemia
PROJECT SUMMARY/ABSTRACT Acute megakaryoblastic leukemia (AMKL) is a form of cancer most prevalent in children under four years old. Targeted AMKL-specific treatment options are li...
Investigating splicing-derived antigens in the context of Rbm10-mutant lung adenocarcinoma
Project summary: The adaptive immune system can specifically recognize and kill cancer cells. Therapies that reinvigorate tumor-specific CD8 T cells cure a subset of patients with...
Illuminating the evolutionary history of colorectal cancer metastasis: basic principles and clinical applications
Background. Metastasis to vital organs is the cause of death in a large majority of cancer patients. Although it is of eminent clinical importance to understand how systemic diseas...
Differential Wnt Dependencies in Colon Epithelium.
Project Summary/Abstract This proposal details a five-year training plan for the development of a research program focused on elucidating the therapeutic potential of superimposed...