Browse All Grants
20,252 grants found
Showing 3,341 – 3,360 of 20,252 grants
Mechanism of double-negative T cells in antitumor immunity to breast cancer
Abstract: Breast cancer (BC), the most common cancer globally as of 2021 and accounting for 12% of all new annual cancer cases worldwide, is the most commonly diagnosed cancer amon...
Prevalence and persistence of the ETV6/RUNX1 pre-leukemic clone
Abstract Leukemia is the most common childhood cancer and represents approximately one third of all cancer diagnoses among children age 0-14. There is strong evidence that acute ly...
Inter-organellar communication in metabolic reprogramming of colorectal cancer
PROJECT SUMMARY Colorectal cancers (CRC) are characterized as having a hierarchical organization requiring proliferating and de-differentiated stem cells to maintain tumor growth a...
Innovative Rapid Enabling, Affordable, point-of-Care HPV Self-Testing Strategy (I-REACH)
Abstract Each day, there are an estimated 28 cervical cancer deaths in Nigeria, making cervical cancer the second most common cancer among women in the entire country. Only a minor...
Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer
Project Summary Pancreatic ductal adenocarcinoma (PDAC) has a median 5-year survival of only 11%, and early diagnosis of PDAC is recognized as one of the highest priority areas by...
Targeting the Immunosuppressive Tumor Microenvironment for Colorectal Cancer Treatment
Project Summary/Abstract Despite notable improvements in colorectal cancer (CRC) treatment, the prognosis of patients with metastatic CRC (mCRC) remains poor, with a median overall...
Role of hypoxia in fibroblast reprogramming in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a prevalent form of pancreatic cancer, accounting for about 90% of all cases of this disease. PDAC is highly fatal, where...
Dissecting the role of GPR34 in cDC1 migration and function
PROJECT SUMMARY/ABSTRACT As critical mediators of immunity against intracellular pathogens and cancer, type 1 conventional dendritic cells (cDC1s) cross-present exogenous, cell-ass...
Molecular MR-PET to characterize malignant transformation and identify therapeutic vulnerabilities in human IDH-mutant gliomas
PROJECT SUMMARY/ABSTRACT The World Health Organization (WHO) classification of gliomas has been steadily shifting from a histological classification towards a molecular classificat...
Tri-Signal Artificial Antigen Presenting Cells for Cancer Immunotherapy
PROJECT SUMMARY Adoptive cellular therapy (ACT) treatments, in which cancer patients are infused with autologous tumor- specific cytotoxic (CD8+) T cells expanded and activated ex...
Roles of LMP1 and MYC in EBV-induced B-cell tumors
PROJECT SUMMARY/ABSTRACT Epstein-Barr virus (EBV) is an important cause of human lymphomas in both immunocompetent and immunosuppressed humans, including Burkitt lymphomas (BLs), H...
Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomas
PROJECT SUMMARY/ABSTRACT Sacrococcygeal teratomas (SCTs) are the most common tumor in newborns, have significant perinatal morbidity and mortality, a 35% rate of recurrence, and la...
Alternate splicing as a source of shared neoantigens in a non-small cell lung cancer
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality in the United States. Immune checkpoint inhibitors (ICIs) like anti-PD-1 have i...
Mechanisms of pathogenic gene activation by aberrant transcriptional hubs formed by mutant ENL
PROJECT SUMMARY Transcription is an essential and tightly regulated process that requires the coordination of many factors to ensure proper gene expression. Current models of trans...
Understanding the role of β2AR-signaling on ILC2 differentiation/plasticity and its implications in cancer progression
Project Summary / Abstract: In preclinical models, norepinephrine released by sympathetic nerves during chronic stress have been demonstrated to promote an immunosuppressive tumor...
Determining the role of nuclear envelope reformation proteins in regulating the cGAS/STING innate immune response in cancer
PROJECT SUMMARY/ABSTRACT: In cancer cells, exposure of self DNA to the cytosol is driven by a variety of genomic instabilities such as micronuclei, chromatin bridges, and nuclear r...
SEMIColon: Somatic Exploration of Mosaicism in Colon
Project Summary/Abstract If we understand the somatic mosaicism of healthy tissues and how this changes through pathogenesis, we will be better equipped to screen for, monitor, and...
Identification of DCLK2-TBK1 signaling axis as a potential therapeutic target in kidney cancer
Project Summary Clear cell renal cell carcinoma (ccRCC), which accounts for approximately 85% of all renal cancers, is resistant to a variety of cancer therapies and is highly leth...
ATF4-SCD axis in bone metastatic prostate cancer
Project Summary Bone metastatic disease correlates with increased morbidity and mortality in prostate cancer (PCa) patients. Various studies, including our own, have determined tha...
Support for the 2023 Society of Basic Urological Diseases annual meeting
PROJECT SUMMARY: This application requests support for 30 Trainee Travel Awards for the Society for Basic Urologic Research (SBUR) 2023 Fall Meeting entitled, “Advances in Basic Ur...