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20,252 grants found
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Development and Evaluation of Advanced Non-Contrast Perfusion MRI for Monitoring Treatment Response in Brain Metastases
Project Abstract Brain metastases (BM) are the most commonly diagnosed type of central nervous system tumor, more frequent than primary intracranial neoplasms. Progress on various...
Transcription and Replication of Oncogenic Viruses in Hypoxia
Summary Oncogenic viruses are major contributors to approximately 20% of human cancers, with about 8 well-known viruses directly shown to be causative agents. Our program will focu...
Project 1: KSHV reprograms replication and metabolic activities in hypoxia
Project #1 Abstract KSHV-associated cancers occur in hypoxic microenvironments. The effects of hypoxia on viral and host DNA replication in the context of KSHV infection are poorly...
Project 2: KSHV induces tumorigenesis by harnessing differentiation in hypoxia
Summary Hypoxia is a characteristic feature of solid tumors and an adverse prognostic factor owing to its contributions to tumor progression and resistance to therapy. Kaposi'...
METEOR-BioLogical Specimen Translation (METEOR-BLST)
The BioLogical Specimen Translation (BLST) Shared Resource of the METEOR ROBIN Center was designed in concert with the leaders of both Projects, the METEORITE cross straining core...
METEOR-Data Synthesis and Transfer (METEOR-DST)
METEOR-DST SUMMARY The METEOR Data Synthesis and Transfer (DST) shared resource provides expertise and systems for synthesizing data from across all data sources in METEOR and enab...
METEOR-Integrated Training Environment (METEORITE)
Project Summary Through existing advances in the field of radiation oncology, it has become clear that success is best achieved when experts in biology, physics, and clinical medic...
Mechanisms and strategies to rescue suboptimal T cell priming in colon cancer
PROJECT SUMMARY/ABSTRACT I propose to functionally interrogate mechanisms of cancer immune evasion and immunotherapy resistance in powerful new mouse models of colorectal cancer (C...
Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck
Abstract Profiling antibody response to disease-associated antigens is important to cancer research. In contrast to the historical approach of testing responses to individual prote...
Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline
PROJECT SUMMARY/ABSTRACT Advances in breast cancer treatment have resulted in significant survival gains. However, cure or control of breast cancer is not necessarily accompanied b...
New Hardware and Software Developments for Improving Prostate Metabolic MR Imaging
Project Summary/Abstract The proposed F31 NRSA Predoctoral Fellowship to Promote Diversity in Health-Related Research project aims to develop new MR detector hardware and acquisiti...
Targeting PRC1 in leukemia
Abstract Acute leukemia is an aggressive disease resulting from various genetic abnormalities and is characterized by the presence of undifferentiated blood cells. Emerging evidenc...
The Meharry Cancer Summer Research Program (SuRP)
PROJECT SUMMARY/ABSTRACT Meharry Medical College seeks funding to support the continuation and expansion of the Meharry Cancer Summer Research Program (SuRP), a research experience...
ATF4-SCD axis in bone metastatic prostate cancer
Project Summary Bone metastatic disease correlates with increased morbidity and mortality in prostate cancer (PCa) patients. Various studies, including our own, have determined tha...
Determining the role of nuclear envelope reformation proteins in regulating the cGAS/STING innate immune response in cancer
PROJECT SUMMARY/ABSTRACT: In cancer cells, exposure of self DNA to the cytosol is driven by a variety of genomic instabilities such as micronuclei, chromatin bridges, and nuclear r...
Dissecting the role of GPR34 in cDC1 migration and function
PROJECT SUMMARY/ABSTRACT As critical mediators of immunity against intracellular pathogens and cancer, type 1 conventional dendritic cells (cDC1s) cross-present exogenous, cell-ass...
Impact of neurofibromin on ER-alpha and nuclear speck post-transcriptional gene regulation
PROJECT SUMMARY Alternative splicing (AS) of transcripts is an essential post-transcriptional process that is instrumental for numerous cell functions including proliferation, diff...
Transcriptome and spatial analyses of tumor environment in addressing colorectal cancer racial and ethnical disparities
PROJECT ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer-related death in the US, with pronounced disparities in mortality by race and ethnicity. Disparities a...
Understanding metabolic and vascular vulnerabilities of residual disease in triple negative breast cancer to inform on treatment strategies
PROJECT SUMMARY/ABSTRACT Recurrence of cancer cells that evade therapy is a leading cause of death. Given that residual disease can persist for years to decades following therapy,...
Next Generation Sequencing Core
Summary Core C: Next Generation Sequencing core (NGSC) The next generation sequencing core (NGSC) will be responsible for all next generation sequencing activities by the four proj...