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20,252 grants found
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CF 1: Biospecimen Repository Core
CF-1: Biospecimen Repository ABSTRACT The Biospecimen Repository Core (CF-1) is designed to provide support to the basic and translational research efforts of the SPORE. The CF-1 w...
CF 2: Biostatistics and Bioinformatics Core
Core 2: Biostatistics and Bioinformatics ABSTRACT The Biostatistics & Bioinformatics Core will support investigators of the Soft Tissue Sarcoma SPORE in the computational and s...
Novel therapeutics development and mechanisms of therapeutic resistance in gastrointestinal stromal tumor (GIST)
RP-1: Novel Therapeutics Development and Mechanisms of Therapeutic Resistance in GIST ABSTRACT Gastrointestinal stromal tumor (GIST) represents one of the most prevalent sarcoma su...
Targeting Oncogenic Pathways in Genetically Complex Sarcomas
RP-3: Targeting oncogenic pathways in genetically complex sarcomas ABSTRACT Our overall goal is to find effective targeted therapies for two of the most common and aggressive types...
Long-Term Trajectories of Accelerated Biological Aging and Functional Decline Associated with Breast Cancer and its Treatment
PROJECT SUMMARY/ABSTRACT More than 3.8 million women living in the United States have a history of invasive breast cancer, a majority of whom are over age 65. With 15-year survival...
Identifying Inflammatory Mediators of Clonal Hematopoiesis
PROJECT SUMMARY/ABSTRACT Clonal hematopoiesis (CH) is a common phenomenon defined as the presence of somatic mutations in hematopoietic stem and progenitor cells (HSPCs) and their...
HOSTING, MAINTENANCE AND PROFESSIONAL SERVICES FOR RAVE AND MEDIDATA RAVE INTEGRATED ANCILLARY SOFTWARE FOR NCI'S CANCER THERAPY EVALUATION PROGRAM (CTEP)
The Contractor shall provide the Parent IDIQ SOW Tasks (Task Areas) 1, 2, 3, 4, and 5 as further described below:a) Hosting (Task 2) and maintenance (Task 3) for Rave-Classic (or R...
Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)
There are currently over 1.2 million people in Zambia and 1.7 million in Tanzania who are living with HIV/AIDS. Concomitant to the HIV epidemic, there is a high incidence of HIV/AI...
Admin Core
A multi-institutional, international, and integrated endeavor, the “KS in the Era of ART in Africa Program (KEAAP)” will leverage the research and training expertise of collaborati...
Project 1
Despite more than a decade of implementing universal access to antiretroviral therapy (ART) in sub-Saharan Africa (SSA), Kaposi’s sarcoma (KS) remains the most common malignancy in...
Molecular mechanism of membrane association of Bruton's Tyrosine Kinase
PROJECT SUMMARY The adaptive immune system is driven by the B Cell receptor (BCR) pathway, which triggers B cell differentiation and proliferation in response to antigen binding. A...
Identification of DCLK2-TBK1 signaling axis as a potential therapeutic target in kidney cancer
Project Summary Clear cell renal cell carcinoma (ccRCC), which accounts for approximately 85% of all renal cancers, is resistant to a variety of cancer therapies and is highly leth...
Cancer Prevention-Interception Against MGUS Progression
Project Summary Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition in which a person has moderately elevated levels of an abnormal immunoglobulin...
Administrative Core
Project Summary The Administrative Core at the Cancer Prevention-Interception against MGUS Progression (CAP-MGUS) Center will provide administrative, scientific, fiscal, and logist...
Prevention of MGUS Progression to MM by Modulating the Bone Marrow Microenvironment
PROJECT SUMMARY The long-term objective of this work is to determine the functional role of the bone marrow microenvironment in regulating the plasma cell growth of monoclonal gamm...
Prevent IgM MGUS Progression by Targeting the Driver Mutation
Prevent IgM MGUS Progression by Targeting the Driver Mutation Project Summary Patients with monoclonal gammopathy of undetermined significance of the IgM class (IgM MGUS) are at in...
Understanding initiation and progression of IPMNs in pancreatic cancer
Project Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal survival rate at just 10%, largely because most patients are diagnosed after the cancer h...
Dartmouth Training Program in Quantitative Cancer Research
ABSTRACT Continued support is requested for a multidisciplinary Dartmouth Training Program in Quantitative Cancer Research (TQCR). The TQCR Program seeks to provide cross-training...
Development of Ubiquitin-Independent Degraders
Project Summary Degraders are chemical dimerizers that recruit a target protein (TP) to an E3 Ubiquitin (Ub) ligase. In favorable cases, this results in TP poly-Ubiquitylation and...
Enhancer RNAs Boost MYC-Chromatin Interaction to Regulate Gene Expression and Tumorigenesis
Enhancer RNAs Boost MYC-Chromatin Interaction to Regulate Gene Expression and Tumorigenesis Summary: Our long-term goal is to determine how MYC’s RNA binding function contributes t...