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20,252 grants found
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Small-molecule degraders of STAT5
Abstract Transducer and Activator of Transcription 5 (STAT5) is a transcriptional factor and has been proposed as an attractive cancer therapeutic target. However, successful of ta...
Regulation of FLT3 Signaling in Leukemia
Summary The temporal and spatial distribution of signaling proteins is dynamically regulated by post-translational modifications (PTMs). PTMs such as phosphorylation, ubiquitinatio...
Cancer misinformation on social media and its correction
Project Summary The overarching goal of this study is to measure the prevalence of cancer misinformation on social media and understand the mechanisms that underlies its spread. Be...
2023 Annual Meeting of the American Society for Investigative Pathology
The 2023 Annual Meeting of the American Society for Investigative Pathology (ASIP), will be held in conjunction with the Tissue, Matrix, and Pathobiology conference from October 22...
Community to Molecular Approaches in Early Screening and Diagnosis to Promote Equitable Outcomes Through the Continuum of Care in Cancer Among Populations of African Ancestry
PROJECT SUMMARY The African-Caribbean Cancer Consortium (AC3) is a Global Oncology Program at Fox Chase Cancer Center and plays a unique role by addressing cancer disparities invol...
Epstein Barr Virus Driven Mechanisms of Post Transplant Lymphoproliferative Disease
PROJECT SUMMARY/ABSTRACT Epstein Barr virus (EBV) is a broadly disseminated gammaherpes virus that, in immunosuppressed or immunocompromised individuals, can cause serious, life-th...
Understanding the immune response changes to clinical interventions for Epstein-Barr virus infection prior to lymphoma development in children after organ transplants (UNEARTH)
Abstract/Summary Among the Epstein-Barr virus associated cancers is post-transplant lymphoproliferative disease (PTLD), a rare but major complication of pediatric solid organ trans...
An Inducible Swine Hepatocellular Carcinoma Platform for Enhanced Therapeutic Development
PROJECT SUMMARY Hepatocellular carcinoma (HCC) is a global health burden ranking as the fourth most common and second deadliest cancer in the world. Effective therapeutic strategie...
VIPCare: Virtual Predictive Care workflow with integrated surveillance for optimal care protocol selection and management in at-risk prostate cancer patients
Abstract Prostate cancer is the leading cancer diagnosis in men (not including skin cancer) and has high survival rates (98% at 5-years), resulting in an estimated 3.2M US men curr...
An off-the-shelf tumor cell vaccine with HLA-matching alleles for the personalized treatment of advanced solid tumors
SUMMARY Cancer vaccines hold promise as immunotherapy due to strong and durable cancer-specific immune responses. Different types of cancer vaccines have been developed, including...
Image-based risk assessment to identify women at high-risk for breast cancer
7. PROJECT SUMMARY Breast cancer is the most common cancer worldwide and the most common cancer diagnosed in American women. While there has been good progress regarding detection...
Monitoring Immunotherapy Response via Gene Silencing Landscapes in Cell-Free DNA
ABSTRACT: Immunotherapies produce remarkable, long-term responses in subsets of patients with non-small cell lung cancer, but unfortunately, most patients do not respond to such tr...
CD3 bispecific for the treatment of ROR2-positive NSCLC
Project Summary We are developing a novel CD3-bispecific antibody product, TB-Bs1, for the treatment of lung cancer. Lung cancer is the leading cause of cancer deaths in both men a...
Antibody-guided localized activation of bioorthogonal protodrugs via click chemistry
Abstract Shasqi is developing a platform to activate drugs at a specific site in the body, thus enhancing their efficacy while minimizing systemic toxicity and adverse drug events...
Development of a novel small molecule RPN13 inhibitor and therapeutic for advanced ovarian cancer patients
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy despite aggressive surgery and toxic chemotherapies. More effective and safer targeted drugs are urgentl...
Spatial genomics analysis of tumor samples
SUMMARY Imaging the tumor microenvironment (TME) is key to understanding tumor growth, disease progression and therapy options. The TME often consists of a complex neighborhood of...
Characterizing an alternatively spliced NTRK2 isoform in development and cancer
Project Summary/Abstract The link between developmental signaling and cancer initiation, maintenance and metastasis has long been known for several members of the Wnt, Hedgehog, an...
Molecular Biology and Genetics of Human Tumor Viruses
PROJECT SUMMARY/ABSTRACT Viruses cause approximately 15% of human cancers. A viral etiology to a human cancer can have substantive consequences on its treatment and prevention. For...
Improving the Generalizability of Deep Neural Networks by Teaching Single Nucleotide Polymorphisms Associated with LDCT Features
PROJECT SUMMARY Diagnostic and treatment approaches for non-small cell lung cancer (NSCLC) have evolved over the last decade from primarily empirical methodologies to objective str...
Experimental and preclinical modeling of NUP98-rearranged acute leukemia
Project Summary The overarching goals of the original FusOnC2 consortium award titled Experimental and Preclinical Modeling of NUP98-rearranged Acute Leukemia are to understand the...