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20,252 grants found
Showing 3,241 – 3,260 of 20,252 grants
SEMIColon: Somatic Exploration of Mosaicism in Colon
Project Summary/Abstract If we understand the somatic mosaicism of healthy tissues and how this changes through pathogenesis, we will be better equipped to screen for, monitor, and...
Molecular MR-PET to characterize malignant transformation and identify therapeutic vulnerabilities in human IDH-mutant gliomas
PROJECT SUMMARY/ABSTRACT The World Health Organization (WHO) classification of gliomas has been steadily shifting from a histological classification towards a molecular classificat...
Blood-Based Biomarkers for Personalized Risk Assessment of Breast and Ovarian Cancer
Project Summary There remains a need to develop biomarker tests for personalized risk assessment of breast and ovarian cancers. Such tests would not replace screening programs but...
Interrogating the Fgl2-FcgRIIB axis: A novel mechanism mediating apoptosis of tumor-specific memory CD8+ T cells
PROJECT SUMMARY One in fifty Americans will be diagnosed with melanoma in their lifetime and skin cutaneous melanoma is the deadliest skin cancer. Cancer immunotherapy is a breakth...
Molecular dissecting and targeting YAP1 mediated cancer stemness and immune suppression in advanced gastric adenocarcinoma
Project Abstract The main objectives of this proposal are to elucidate the mechanisms of YAP1-mediated metastatic niche and immunosuppression in gastric adenocarcinoma (GAC) with p...
Cognitive aging in long-term breast cancer survivors
ABSTRACT Despite significant progress in understanding cognitive change associated with cancer and cancer treatments, little is known regarding longer-term cognitive outcomes over...
Molecular Determinants of Response and Resistance to EZH2 and PARP inhibition in Prostate Cancer
PROJECT SUMMARY- PROJECT 2 Castration resistant prostate cancer (CRPC) is a lethal disease. Epigenetic dysregulation, including overexpression of the enhancer of zeste homolog 2 (E...
Dissecting and Predicting Lethal Prostate Cancer using Biologically Informed Artificial Intelligence
PROJECT SUMMARY – PROJECT THREE Treatment strategies for intermediate and high-risk localized prostate cancer (PCa) include surgery or radiation with or without hormonal therapy. M...
Biostatistics/Computational Core
PROJECT SUMMARY – BIOSTATISTICS AND COMPUTATIONAL CORE (CORE B) The Biostatistics and Computational Core (Core B) of the Dana-Farber/Harvard Cancer Center (DF/HCC) Prostate SPORE i...
Biospecimen Core
PROJECT SUMMARY – BIOSPECIMEN CORE (CORE C) Acquisition and characterization of biospecimens linked with clinical data and the development of patient relevant preclinical models,...
Structural studies of metazoan origin licensing
Project Summary Developing effective cancer therapies remains a significant challenge due to the heterogeneity of tumor physiology, cytotoxicity towards non-cancer cells, and the e...
Role of hypoxia in fibroblast reprogramming in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a prevalent form of pancreatic cancer, accounting for about 90% of all cases of this disease. PDAC is highly fatal, where...
Understanding metabolic and vascular vulnerabilities of residual disease in triple negative breast cancer to inform on treatment strategies
PROJECT SUMMARY/ABSTRACT Recurrence of cancer cells that evade therapy is a leading cause of death. Given that residual disease can persist for years to decades following therapy,...
Translation of a novel combination therapy approach for non-Hodgkin lymphoma
Translation of a novel combination therapy approach for non-Hodgkin lymphoma . Diffuse large B-cell lymphoma is the most common type of Non-hodgkin’s lymphoma (NHL) with limited tr...
Dissecting Early Tumor Evolution to Uncover Mechanisms of Tumor Initiation and Drug Resistance
PROJECT SUMMARY/ABSTRACT Despite the prevalence of prostate cancer worldwide, we lack an understanding of the genetic events that drive tumor initiation or drug resistance. Only a...
Differentiation-focused CRISPR Screen identifies LSD1 and Menin as combination therapy targets that induce terminal differentiation in AML
Project Summary Acute myeloid leukemia (AML) is a lethal blood cancer characterized by a differentiation “block” that prevents myeloid progenitor maturation resulting in uncontroll...
MYCN drives a ferroptotic vulnerability in neuroblastoma
Project Summary: Apoptosis is a type of programmed cell death and has for a long time been appreciated to be a hallmark of cancer cells. In recent years, drugs targeting the apopto...
Antibody-guided localized activation of bioorthogonal protodrugs via click chemistry
Abstract Shasqi is developing a platform to activate drugs at a specific site in the body, thus enhancing their efficacy while minimizing systemic toxicity and adverse drug events...
Controlled Antigen Delivery for Prophylactic Cancer Vaccination
ABSTRACT In the United States, cancer is the second leading cause of death, and it is projected that 39.5% of all US adults will be diagnosed with cancer in their lifetimes. Carcin...
Next generation T cell therapies for mutant KRAS solid tumors
Project Summary This proposal “Next generation T cell therapies for KRAS mutated solid tumors” was developed in response to RFA-CA-22-028 and to fulfill the Cancer Adoptive Cellula...