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20,252 grants found
Showing 3,221 – 3,240 of 20,252 grants
Targeting Nonsense-Mediated RNA Decay in Splicing Factor Mutant Myeloid Malignancies.
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by peripheral blood cytopenias, bone marrow dysplasia, and ineff...
Targeting pancreatic cancer's metabolic addiction to HuR
Pancreatic ductal adenocarcinoma (PDA) is the 3rd leading cause of cancer death in the U.S. and is generally refractory to chemotherapy. We discovered that the harsh PDA microenvir...
HCC Ovarian Cancer SPORE
PROJECT SUMMARY/ABSTRACT – OVERALL Ovarian cancer (OvCa) has the third highest mortality to incidence ratio and is the fifth leading cause of cancer death in American women. The ty...
Administrative Core
PROJECT SUMMARY/ABSTRACT – CORE A The HCC OvCa SPORE Administrative Core (Core A) is co-directed by SPORE PIs Ronald Buckanovich, MD, PhD and Robert Edwards, MD. Core A will (i) pr...
Project 1: EZH2 Inhibition to Prevent/Overcome Chemoresistance
ABSTRACT – PROJECT 1 The ability to overcome the development of chemotherapy resistance and maintain sensitivity to the most effective chemotherapy in ovarian cancer, platinum, is...
Project 2: Combination PARPi-BETi to Overcome PARPi Resistance
ABSTRACT – PROJECT 2 PARP inhibitors have emerged as an established standard of care option in epithelial ovarian cancer (OvCa). Approximately half of OvCa patients harbor inactiva...
Project 3: Hedgehog Inhibition to Enhance Response to ICI Therapy
SUMMARY/ABSTRACT – PROJECT 3 When effective, immune checkpoint inhibitor (ICI) therapy can significantly improve the outcome of patients with ovarian cancer (OvCa). However, only 1...
Core B: TCP: Translational Pathology Core
PROJECT SUMMARY – TRANSLATIONAL PATHOLOGY CORE The high case-fatality of ovarian cancer makes translational studies essential for advancing treatment and improving outcomes. The Hi...
Core C: BBC: Biostats and Bioinformatics Core
PROJECT SUMMARY – BIOSTATISTICS/BIOINFORMATICS CORE The Biostatistics/Bioinformatics Core of the Hillman Cancer Center (HCC) Ovarian Cancer (OvCa) SPORE provides services for the d...
DRP: Developmental Research Program
PROJECT SUMMARY – DEVELOPMENTAL RESEARCH PROGRAM (DRP) The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center (HCC) Ovarian Cancer SPORE seeks to fund and facil...
CEP: Career Enhancement Program
PROJECT SUMMARY – CAREER ENHANCEMENT PROGRAM (CEP) The mission of the Hillman Cancer Center (HCC) Ovarian Cancer (OvCa) SPORE Career Enhancement Program (CEP) is to foster the deve...
Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)
There are currently over 1.2 million people in Zambia and 1.7 million in Tanzania who are living with HIV/AIDS. Concomitant to the HIV epidemic, there is a high incidence of HIV/AI...
Regulation of Genome Stability and Structure by the Nucleosome Remodeler HELLS in Leukemia
Project Summary/Abstract Eukaryotic cells require the tight regulation of global gene expression to maintain homeostasis and respond to environmental stimuli. DNA spools around his...
Developing LG007 as a novel therapeutic agent to treat triple negative breast cancer
PROJECT SUMMARY: For women in the United States, breast cancer is the most common malignancy and the second leading cause of death. In this application, we focus upon a specific su...
Southern Environmental Health Study
SUMMARY Approximately 80% of human cancers are caused by adverse environmental exposures, unhealthy lifestyles and/or their interactions with host susceptibility factors. Previous...
The roles of AP-1 pathway activation in NK cell development and exhaustion programming in AML
PROJECT SUMMARY/ABSTRACT The 5-year overall survival rate for acute myeloid leukemia (AML) is less than 35%, making it the most fatal leukemia in adults. Natural killer (NK) cells...
Investigating tRNA biology as a prognostic and oncogenic feature in pancreatic adenocarcinoma
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is uniquely difficult to treat due to late diagnosis and limited medical management options for a majority of patients. This...
Multiscale modeling of spatiotemporal evolution in Barrett's esophagus
PROJECT SUMMARY The practical goal of this project is to obtain high-resolution genetic and epigenetic maps that reveal the evolutionary relationships and dynamics over space and t...
Mechanisms of pathogenic gene activation by aberrant transcriptional hubs formed by mutant ENL
PROJECT SUMMARY Transcription is an essential and tightly regulated process that requires the coordination of many factors to ensure proper gene expression. Current models of trans...
Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomas
PROJECT SUMMARY/ABSTRACT Sacrococcygeal teratomas (SCTs) are the most common tumor in newborns, have significant perinatal morbidity and mortality, a 35% rate of recurrence, and la...