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20,252 grants found
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Deciphering the functional role of recurrent PPP2R1A mutations on endometrial metastasis
Project Summary: Uterine serous carcinomas (USC), uterine carcinosarcomas (UCS), and leiomyosarcomas represent the most aggressive subtypes of uterine cancer and account for a disp...
Examining the impact of laboratory housing temperature on murine CD28 and the response to anti-PD-1
Project Abstract/Summary For decades, animals in biomedical research have yielded significant scientific and medical breakthroughs by generating the essential preclinical data that...
Development of a novel small molecule RPN13 inhibitor and therapeutic for advanced ovarian cancer patients
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy despite aggressive surgery and toxic chemotherapies. More effective and safer targeted drugs are urgentl...
The PLOD2/succinate axis in cancer cell plasticity and stemness
Abstract Tumor cells in TNBC tissue exhibit enhanced cell plasticity and stemness, which is crucial for cancer metastasis. Metabolic and epigenetic reprogramming plays crucial role...
DF/HCC Prostate SPORE
PROJECT SUMMARY – OVERALL The Dana-Farber/Harvard Cancer Center (DF/HCC) Prostate SPORE seeks to improve the understanding and treatment of prostate cancer using a highly translati...
DF/HCC Prostate SPORE
PROJECT SUMMARY – ADMINISTRATIVE CORE (CORE A) The DF/HCC Prostate SPORE Administrative Core (Core A) is instrumental for the overall function and success of the Prostate SPORE pro...
Efficacy and Mechanisms of Resistance to Neoadjuvant Intensive Androgen Signaling Inhibition
PROJECT SUMMARY – PROJECT 1 Localized high-risk prostate cancer (PCa) comprises ~15% of newly diagnosed localized PCa, and the cure rate for these tumors after primary surgical tre...
Career Enhancement Program
PROJECT SUMMARY – CAREER ENHANCEMENT PROGRAM (CEP) The goal of the DF/HCC Prostate SPORE Career Enhancement Program (CEP) is to provide resources, financial support, and mentorship...
Understanding the immune response changes to clinical interventions for Epstein-Barr virus infection prior to lymphoma development in children after organ transplants (UNEARTH)
Abstract/Summary Among the Epstein-Barr virus associated cancers is post-transplant lymphoproliferative disease (PTLD), a rare but major complication of pediatric solid organ trans...
Epigenetic dependence of diffuse midline glioma with H3K27M mutation
Diffuse intrinsic pontine glioma (DIPG) is a deadly disease with the median survival of DIPG patients less than one year after diagnosis. DIPG tumors initiate from the pons and mid...
Modeling and Dissecting Epigenetic Drivers of Gliomagenesis
PROJECT SUMMARY Diffuse gliomas are incurable brain tumors despite aggressive therapies 1–4. Understanding the mechanisms that initiate gliomas is a critical step towards improving...
Systematic Characterization of Small Nucleolar RNAs in Cancer
Abstract Despite recent advancements in treatment options for cancer, a majority of cancer types continue to lack fully characterized and effective targeted therapies. This insuffi...
Roles of LMP1 and MYC in EBV-induced B-cell tumors
PROJECT SUMMARY/ABSTRACT Epstein-Barr virus (EBV) is an important cause of human lymphomas in both immunocompetent and immunosuppressed humans, including Burkitt lymphomas (BLs), H...
Inferring Kinase Activity from Tumor Phosphoproteomic Data
Project Summary Kinases are fundamentally important enzymes for regulating cell physiology through regulation of proteins and protein interactions by phosphorylating tyrosine, seri...
GARDE: Scalable Clinical Decision Support for Individualized Cancer Risk Management
PROJECT SUMMARY/ABSTRACT Evidence supports individualizing risk-stratified cancer screening, with selective application of specific screening interventions best suited to the indiv...
Identifying genetic vulnerabilities in KIAA1549-BRAF mutant pediatric low-grade gliomas
Project Summary: Pediatric low-grade gliomas (pLGGs) typically harbor only a single oncogenic driver event which almost universally result in MAPK pathway activation. The most freq...
Fertility legislation and unmet needs: Exploring intervenable barriers for quality oncofertility care among adolescent and young adult cancer patients
PROJECT SUMMARY/ABSTRACT Curative cancer treatment modalities (e.g., chemotherapy) are gonadotoxic (i.e., destroy sperm and eggs) and frequently cause infertility. Thus, clinical p...
Metabolism of cancer chemotherapeutics by the human gut microbiome
PROJECT SUMMARY – NO CHANGES FROM PARENT GRANT Rigorous data from our lab and others indicate that the gut microbiome may an underappreciated contributor to inter-individual variat...
Cancer misinformation on social media and its correction
Project Summary The overarching goal of this study is to measure the prevalence of cancer misinformation on social media and understand the mechanisms that underlies its spread. Be...
Cell-free DNA Analysis for Liquid Biopsy of Cancer
PROJECT SUMMARY/ABSTRACT Circulating tumor DNA (ctDNA) which mirrors the parental tumor, is present in the plasma of non-small cell lung carcinoma (NSCLC) patients. Liquid biopsy a...