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20,252 grants found
Showing 3,181 – 3,200 of 20,252 grants
NCI-sponsored Clinical Trial Research Specialist
ABSTRACT NCI-sponsored clinical trials represent some of the highest priority clinical trials conducted by the UF Health Cancer Center (UFHCC). These trials include participation b...
Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary gland
Abstract/Project Summary The goal of this proposal is to understand how transitions through pregnancy influence the molecular and cellular state of mammary epithelial cells and onc...
Small-molecule degraders of STAT5
Abstract Transducer and Activator of Transcription 5 (STAT5) is a transcriptional factor and has been proposed as an attractive cancer therapeutic target. However, successful of ta...
Regulation of FLT3 Signaling in Leukemia
Summary The temporal and spatial distribution of signaling proteins is dynamically regulated by post-translational modifications (PTMs). PTMs such as phosphorylation, ubiquitinatio...
Quantitation of nutrient metabolism in brain tumor patients using advanced 13C isotopomer technology
Project Summary/Abstract Malignant brain tumors are aggressive cancers that have high proliferative rates with much higher energy requirements and high mortality rates. Despite int...
Integrated delivery of cancer control interventions for adolescents and young adults living with HIV in Zambia
PROJECT SUMMARY/ABSTRACT Zambia is a global epicenter for HIV with a large number of adolescents and young adults living with HIV (AYAHIV). Compared with their uninfected peers, AY...
University of California, Davis: Human Papillomavirus Cancer Free (UCD: HPV Cancer Free)
This K01 award resubmission outlines an intensive five-year research career development program focused on multilevel behavioral intervention and dissemination and implementation s...
Development of CA-IL-12 for Triple Negative Breast Cancer
Most cancer patients die as a result of metastatic disease and our inability to effectively deliver therapeutic drugs into the anatomical niches where cancer cells thrive. Thus, th...
MYCN drives a ferroptotic vulnerability in neuroblastoma
Project Summary: Apoptosis is a type of programmed cell death and has for a long time been appreciated to be a hallmark of cancer cells. In recent years, drugs targeting the apopto...
Developmental Research Program
PROJECT SUMMARY– DEVELOPMENTAL RESEARCH PROGRAM (DRP) The objective of the SPORE Developmental Research Program (DRP) is to identify and support exciting prostate cancer research a...
Spatial genomics analysis of tumor samples
SUMMARY Imaging the tumor microenvironment (TME) is key to understanding tumor growth, disease progression and therapy options. The TME often consists of a complex neighborhood of...
The impact of cannabis and tobacco/nicotine product co-use in young adults: Prospective cessation evaluation and substitution
PROJECT SUMMARY/ABSTRACT The co-use of nicotine/tobacco products and cannabis among young adults is prevalent and varies widely in terms of patterns and products of use. Nicotine-c...
Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)
PROJECT SUMMARY / ABSTRACT Cancer is the second most frequent cause of death in children under 15-years of age, and primary central nervous system (CNS) tumors are the most frequen...
Elucidating the mechanisms by which the extracellular matrix contribute to gastroesophageal cancer pathobiology
ABSTRACT Gastric cancer (GC), the third leading cause of cancer death worldwide, is characterized both by histologic and molecular criteria. The two most common forms include Diffu...
Machine Learning and Radiomics Techniques for Analysis of Daily MRI in Glioblastoma Patients
PROJECT SUMMARY Glioblastoma is the most common primary brain cancer worldwide. Novel treatment strategies are urgently needed since glioblastoma is nearly universally fatal with a...
VIPCare: A cancer patient surveillance platform that runs clinical workflow for identifying, tracking, evaluating and engaging cancer surveillance cases.
Abstract Prostate cancer is the leading cancer diagnosis in men (not including skin cancer) and has high survival rates (98% at 5-years), resulting in an estimated 3.2M US men curr...
Improving the Generalizability of Deep Neural Networks by Teaching Single Nucleotide Polymorphisms Associated with LDCT Features
PROJECT SUMMARY Diagnostic and treatment approaches for non-small cell lung cancer (NSCLC) have evolved over the last decade from primarily empirical methodologies to objective str...
Defining the role of persistent DNA bridges in tumor-intrinsic immune activation in hereditary breast and ovarian cancer
PROJECT SUMMARY Chromosome segregation errors such as persistent DNA bridges accelerate genome instability, a hallmark of cancer. These toxic DNA lesions occur at a higher frequenc...
Text-messaging Communication Micro-Intervention for Couples Coping with Advanced GI Cancer
A cancer diagnosis requires patients and their intimate partners to communicate effectively to navigate illness- related challenges. Research indicates that couples who use effecti...
DELINEATE THE TUMOR IMMUNE MICROENVIRONMENT FOR BETTER UNDERSTANDING IMMUNOTHERAPY RESPONSE
Project Summary Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition in which a person has moderately elevated levels of an abnormal immunoglobulin...