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20,252 grants found
Showing 301 – 320 of 20,252 grants
Sample-to-answer HPV DNA nucleic acid test for cervical cancer screening in Mozambique
PROJECT SUMMARY / ABSTRACT Cervical cancer is the 4th most common female cancer and cause of cancer-related mortality worldwide, despite being preventable through HPV (human papill...
A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer
7.0 Project Summary/Abstract Up to 70% of patients with advanced cancer experience significant levels of FOP. FOP is the most common psychosocial concern among GYN and other cancer...
A randomized comparative effectiveness trial of nicotine pouches for cigarette substitution: A question of public health
PROJECT SUMMARY Commercial cigarette smoking is a modifiable risk factor implicated in one-third of all cancer deaths. Nicotine is the chief addictive agent causing sustained smoki...
Mutant KRAS targeted vaccines for the interception of pancreatic cancer development
ABSTRACT The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing, and despite the use of conventional therapies, including immune checkpoint inhibitors, 5–year survi...
ComPASS Health Equity Research Hub at UMB
ABSTRACT Despite decades of concerted efforts to eliminate health disparities experienced by minority racial and ethnic groups and other underserved populations, there remains a cr...
Identification of proteins for breast cancer risk: an integrative epidemiologic and genomic study
Project Summary Genome-wide association studies (GWAS) have identified over 200 genetic loci for breast cancer. To translate these findings into an improved understanding of cancer...
Investigating the cell intrinsic and extrinsic mechanisms governing lung cancer cell plasticity
PROJECT SUMMARY During tumor evolution, cancer cells can acquire phenotypic heterogeneity, enabling them to grow more aggressively, invade neighboring tissues, evade the immune sys...
Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
ABSTRACT DNA double-strand breaks (DSB)s occur upon exposure of cells to ionizing radiation and chemicals in the environment, and when DNA replication forks become impeded by lesio...
Admin Core: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
ABSTRACT DNA double-strand breaks (DSB)s occur upon exposure of cells to ionizing radiation and chemicals in the environment, and when DNA replication forks become impeded by lesio...
Single-molecule nanopore-based identification of methylome signatures in cfDNA for early colorectal cancer detection
ABSTRACT The detection and characterization of cell-free DNA (cfDNA) is increasingly being used to detect cancer – this modality is frequently referred to as a liquid biopsy. Epige...
Project 3: Antagonistic Mechanisms of BRCA2 and the 53BP1 Axis in RAD51 Nucleoprotein Filament Assembly
Project Summary Homology-directed repair (HDR) is a major, high-fidelity pathway for the elimination of DNA double-strand breaks (DSB)s and for DNA replication fork maintenance. De...
Core 1: Protein Biochemistry and Enzymology (PBE) Core
ABSTRACT DNA double-strand breaks (DSB)s are eliminated primarily through two mechanistically distinct pathways, namely, non-homologous DNA end joining (NHEJ) and homology-directed...
Core 2: Chromosome Replication and Analysis (CRA) Core
ABSTRACT Failure to properly repair DNA double-strand breaks (DSBs) or damaged DNA replication forks leads to chromosome aberrations and neoplastic transformation of cells. Homolog...
Core 3: Structural Biology and Biophysics (SBB) Core
ABSTRACT The Structural Biology and Biophysics (SBB) Core will provide Program Project Investigators with high-qual- ity atomic resolution mapping and quantification of salient pro...
Developing a Cancer Galaxy Computational Workbench to Meet Emerging Cancer Data Analysis Needs
PROJECT SUMMARY Computational analyses have become instrumental to cancer research, but only a minority of cancer researchers are computational scientists. Cancer researchers—espec...
Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphoma
PROJECT SUMMARY/ABSTRACT Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poor outcome. Thus far, eff...
Improving CAR T-cell therapy for Pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL)
PROJECT SUMMARY My long-term career goal is to develop an independent research program focused on evaluation of novel cellular therapies designed to improve long-term outcomes for...
Targeting mitochondrial oxygen demand to overcome hypoxic immune privilege of NSCLC tumors
ABSTRACT Non-small cell lung cancer (NSCLC) is a highly aggressive disease with dismal prognosis associated with high rates of treatment resistance and disease recurrence. In the l...
Preparing Nurse Scientists to Lead the Future of Oncology Research
Until recently, the concept of the “oncology nurse” was limited to those having extra competency in administering chemotherapy, coordinating care delivery, or working with investig...
Clinical assessment of radiotherapy-induced vaginal toxicity with multiparametric ultrasound imaging
PROJECT SUMMARY/ABSTRACT Pelvic radiotherapy is the standard of care for numerous gynecological and anorectal cancers affecting women. Post-operative intravaginal brachytherapy (IV...