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20,252 grants found
Showing 3,161 – 3,180 of 20,252 grants
Bioinformatics Core
Bioinformatics Core Project Summary All forms of the incurable plasma cell malignancies, multiple myeloma (MM), and Waldenstrom’s macroglobulinemia (WM) emerge from a precursor con...
Examining the Role of RNF168 Activity in BRCA1 Mutant Cancers
PROJECT SUMMARY/ABSTRACT My career goal is to develop an independent research program focused on DNA damage signaling and how it can be exploited for the treatment of cancer. The w...
Washington University (WU) ROBIN Center: MicroEnvironment and Tumor Effects Of Radiotherapy (METEOR)
Project Summary In addition to direct killing of rapidly proliferating tumor cells, radiation therapy (RT) modifies tumor immunity. RT increases the expression and release of tumor...
METEOR Administrative Core
ADMINISTRATIVE CORE SUMMARY Critical to the success of the Washington University (WU) ROBIN “MicroEnvironment Tumor Effects Of Radiotherapy” (METEOR) Center is a structured approac...
METEOR-Comprehensive Radiobiology Assessment TRial (METEOR-CRATR)
MOLECULAR CHARACTERIZATION TRIAL SUMMARY The standard of care (SOC) for locally advanced cervical cancer, pelvic radiation (RT) with concurrent cisplatin, is associated with a 30-5...
Research Project Cervical Cancer
PROJECT 1 SUMMARY (CERVIX) The standard of care (SOC) for locally advanced cervical cancer, pelvic radiation (RT) with concurrent cisplatin, is associated with a 30-50% failure rat...
Research Project Pancreatic Cancer
PROJECT 2 (PANCREAS) SUMMARY The prognosis for pancreatic ductal adenocarcinomas (PDAC) patients is dismal. Unfortunately, attempts at immunotherapy for PDAC to date have not achie...
Project 3: Skin hypoxia, MCPyV infection, and MCC tumorigenesis
Project Abstract Merkel cell carcinoma (MCC) is one of the most aggressive skin cancers. Clonal integration of Merkel cell polyomavirus (MCPyV) genome into the host DNA has been ob...
Project 4: Regulation of EBV Latency and Oncogenesis by Hypoxia
Abstract: Epstein-Barr Virus (EBV) a human gammaherpesvirus that is associated with diverse lymphoid and epithelial malignancies. Like all cancers, EBV-associated cancers must comp...
Administrative Core
Abstract Core A: Program Administration The mission of the Administrative core is to maintain a cohesive program through facilitating interactions between the three projects and th...
Virus, Vector and Cell Culture Core
Abstract Core B: Virus Vector and Cell Culture Core The Virus Vector and Cell Culture Core (VVCCC) will be responsible for 1) recombinant virus design consultation, 2) vector and v...
Generating Research Opportunities Within Statistics at Fred Hutch (GROWS@FredHutch)
Project Summary/Abstract In cancer research, the need for a diverse pool of researchers in statistics and data science has never been greater. Yet, the requisite academic pipeline...
Immunoglobulin Replacement Therapy and Infectious Complications After CD19-Targeted CAR-T-Cell Therapy
PROJECT SUMMARY/ABSTRACT Chimeric antigen receptor T cell therapy (CARTx) has transformed treatment for B cell malignancies. However, the effects of CARTx on humoral immunity and i...
Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression: A double-blind randomized controlled trial
ABSTRACT The incidence of metastatic prostate cancer has increased 3% per year since 2012, and the survival rate is only 29%. Muscle mass is important for metastatic prostate cance...
Multi-omics for obesity-associated liver disease discovery in Hispanics/Latinos: the Cameron County Hispanic Cohort
ABSTRACT We submit “Multi-omics for obesity-associated liver disease discovery in Hispanics/Latinos: the Cameron County Hispanic Cohort” (hereafter CCHC-Liver) in response to RFA-H...
Impact of TNF on Oncolytic Virotherapy
Project Summary: Oncolytic virotherapy (OV) represents a novel method to treat a variety of solid tumors by inducing anti-tumor immune responses. While this therapy has been extrem...
Epstein Barr Virus Driven Mechanisms of Post Transplant Lymphoproliferative Disease
PROJECT SUMMARY/ABSTRACT Epstein Barr virus (EBV) is a broadly disseminated gammaherpes virus that, in immunosuppressed or immunocompromised individuals, can cause serious, life-th...
Pediatric and Adult Translational Cancer Drug Discovery and Development Training Program (PACT-D3)
Abstract This training program is unique for our institution, creating the next generation of basic and clinical investigators who focus their efforts on strategic and comprehensiv...
Cancer Adoptive Cell Therapy (Can-ACT) Network Coordinating Center at Mayo Clinic
PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of s...
Local Tumoral Delivered Immune Checkpoint Blockades Immunotherapy and Radioembolization Combination Therapy
PROJECT SUMMARY Systemic mono- or combination- immune checkpoint blockade (ICB) immunotherapy has been an established therapeutic paradigm. However, a risk of serious autoimmune si...