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20,252 grants found
Showing 3,141 – 3,160 of 20,252 grants
Admin-Core-001
Project Summary/Abstract: The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core combine with synergy beyond their individ...
STABLE CLONE PRODUCTION FOR ANTI-EBV MONOCLONAL ANTIBODIES
Epstein-Barr virus (EBV) is the major cause of post-transplant lymphoproliferative disease (PTLD) and EBV lymphoma in stem cell and organ transplant recipients. Persons who are EBV...
SUCCEED Administrative Core
ADMINISTRATIVE CORE: PROJECT SUMMARY The Administrative Core will provide scientific and programmatic leadership to ensure the unifying scientific mission of the Virginia State Uni...
Pragmatic Implementation Science Approaches to Assess and Enhance Value of Cancer Prevention and Control in Rural Primary Care
Project Summary/Abstract – Administrative Core The theme of our proposed Implementation Science Center is “Pragmatic implementation science approaches to assess and enhance the val...
Pragmatic Implementation Science Approaches to Assess and Enhance Value of Cancer Prevention and Control in Rural Primary Care
Project Summary/Abstract – Administrative Core The theme of our proposed Implementation Science Center is “Pragmatic implementation science approaches to assess and enhance the val...
Admin-Core-001
ADMINISTRATIVE CORE – SUMMARY The proposed Acquired Resistance to Therapy and Iron (ARTI) Center is focused on the role of ferroptosis in acquired resistance to radiation therapy.R...
Administrative Core
Summary: The Administrative Core of the University of Massachusetts, Boston (UMass Boston) and Dana- Farber/Harvard Cancer Center (DF/HCC) Partnership takes an integrated approach...
Admin-Core-001
Administrative Core (Core A) SUMMARY The Administrative Core, led by Dr. Jeffrey Myers and Dr. Vlad Sandulache, and supported by the Center Administrator Dr. Toyin Babarinde, is an...
Metabolic adaptation enables cisplatin resistance and inhibits tumor immunity
Head and neck squamous cell carcinoma (HNSCC) remains a leading cause of cancer death worldwide, with ~500,000 cases/year. Cisplatin is the gold standard systemic agent for HNSCC.C...
Determinants of resistance to engineered T-cell therapies targeting CD19 in lymphoma
Determinants of resistance to engineered T-cell therapies targeting CD19 in lymphoma The outcomes for patients with large B-cell lymphoma (LBCL) that are relapsed or refractory to...
Modeling the equity impact of age restricted in-person location policies for youth tobacco use
PROJECT SUMMARY/ABSTRACT This proposal concerns age restricted in-person location policies (ARLPs), a novel tobacco control strategy that could have a critical impact on reducing y...
Znf740 in the regulation of CD8+T cell exhaustion
ABSTRACT: CAR-T cell therapy is an emerging option for cancer treatment, but its efficacy is limited, especially in solid tumors, because the effector CD8+T cells become dysfunctio...
Project 2
HIV-associated Kaposi sarcoma (KS), also known as epidemic Kaposi sarcoma (EpKS), is a leading malignancy in sub-Saharan Africa (SSA). It is among the top 10 malignancies by incide...
Project 3
ABSTRACT Kaposi sarcoma (KS), an HIV/AIDS-associated malignancy, is one of the most prevalent cancers in people living with HIV-1 (PLWH) in sub-Saharan Africa (SSA). AIDS-associate...
Data Core
ABSTRACT The Data Management and Integration Core (DMIC) of the Kaposi Sarcoma (KS) in Era of Antiretroviral Therapy in Africa Program (KEAAP) is responsible for streamlining and c...
Developmental Core
ABSTRACT Human resource capacity building and training are urgently needed to establish a sustainable research enterprise that will improve prevention, diagnosis, connection to car...
Elucidating the role of mRNA m6A methylation in tumorigenesis
PROJECT SUMMARY/ABSTRACT The current lack of effective, targeted cancer therapies reflects a gap in knowledge surrounding the mechanisms that promote tumorigenesis and emphasizes t...
Fibroblasts in the establishment of the liver pre-metastatic niche
PROJECT SUMMARY Postpartum breast cancer (PPBC), defined as breast cancer diagnosed within 10-years after a women's last childbirth, accounts for 50% of young women's bre...
Dissecting the tumor cell-immune TME axis to identify therapeutically actionable vulnerabilities that potentiate immunotherapy in GBM
Glioblastoma multiforme (GBM) is a common and highly aggressive form of brain cancer in adults with a dismal prognosis and limited therapeutic options. A critical component of GBM...
Deep Sequencing of Relapse and Refractory Hodgkin Lymphoma Genomes: A Study of Tumor Biology and Evolution
Hodgkin lymphoma (HL) accounts for ten percent of all lymphomas in the western world and remains a substantial clinical problem. Relapsed and refractory (R/R) HL presents a particu...