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20,252 grants found
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Prevention of MGUS Progression to MM by Modulating the Bone Marrow Microenvironment
PROJECT SUMMARY The long-term objective of this work is to determine the functional role of the bone marrow microenvironment in regulating the plasma cell growth of monoclonal gamm...
Prevent IgM MGUS Progression by Targeting the Driver Mutation
Prevent IgM MGUS Progression by Targeting the Driver Mutation Project Summary Patients with monoclonal gammopathy of undetermined significance of the IgM class (IgM MGUS) are at in...
Bioinformatics Core
Bioinformatics Core Project Summary All forms of the incurable plasma cell malignancies, multiple myeloma (MM), and Waldenstrom’s macroglobulinemia (WM) emerge from a precursor con...
Epigenetics, Metabolism and Cancer
Project Summary It is now well accepted that epigenetic and metabolic factors are major drivers of tumorigenesis and the link between the two pathways will be central in cancer the...
Determinants of resistance to engineered T-cell therapies targeting CD19 in lymphoma
Project Summary/Abstract The outcomes for patients with large B-cell lymphoma (LBCL) that are relapsed or refractory to frontline therapy remain quite poor. While anti-CD19 chimeri...
Metabolism of cancer chemotherapeutics by the human gut microbiome
PROJECT SUMMARY Rigorous data from our lab and others indicate that the gut microbiome may an underappreciated contributor to inter-individual variations in cancer drug efficacy an...
Alternate splicing as a source of shared neoantigens in a non-small cell lung cancer
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality in the United States. Immune checkpoint inhibitors (ICIs) like anti-PD-1 have i...
Transcriptional Regulation of Dormancy and Emergence in Breast Cancer
Breast cancer ranks second among cancer deaths in women in the United States. Breast cancer-related mortality primarily results from metastatic growth of disseminated cells. While...
Role of hypoxia in CD8+ T cell exclusion and suppression in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great prom...
Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program
PROJECT SUMMARY The goal of the Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program is to provide 25 talented first-year medical students per year...
Development of Mouse and Humanized Models to Study Sex Disparities in Tumor Progression and Treatment of NSCLC
Project Summary According to the American Cancer Society, lung cancer is the second most commonly diagnosed cancer in men and women. Outside of the sex-specific cancers, lung cance...
Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
Abstract In women, breast cancer is the most commonly diagnosed cancer and leading cause of cancer related deaths worldwide, with approximately 2.3 million new cases and 685,000 de...
A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors
Summary Cellular mRNAs are susceptible to a variety of chemical modifications that play important roles in regulating gene expression and cellular function. The most abundant inter...
Refer 2 Quit: Proactive Promotion of Tobacco Use Treatment for Underserved Household Members Who Smoke through Pediatric Primary Care
Project Summary/Abstract Racial and ethnic minority groups and those from low socioeconomic groups suffer disproportionately from the effects of tobacco marketing, have less access...
Design and implementation of a social cognitive theory-based medication adherence coaching intervention
ABSTRACTDr. Benyam Muluneh’s long-term career goal is to become a leading clinician-researcher in oncology by leveraging health behavior theories and implementation science methods...
Social Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and Aging
By 2030, three-quarters of the 22 million US cancer survivors will be 65 and older and the number of older Hispanic and Black survivors will have grown three times faster than Whit...
The role of stem-like CD8 T-cells in the abscopal response
PROJECT SUMMARY Prognosis is poor for patients diagnosed with locally advanced melanoma. Survival outcomes are improved with checkpoint blockade in the neoadjuvant, adjuvant and un...
Administrative Core
PROJECT SUMMARY (ADMINISTRATIVE CORE) The Administrative Core provides essential support to the MD Anderson Cancer Center and Temple/Fox Chase Cancer Center Leukemia SPORE PIs and...
Core 3: Biostatistics, Data Management, and Bioinformatics
Project Summary The major objective of the Biostatistics and Bioinformatics Core (Core 3) is to provide centralized biostatistics, bioinformatics, and database support for all Proj...
Epigenetic and Genetic Vulnerabilities in Synovial Sarcoma
ABSTRACT RP-4 focuses on synovial sarcoma, an aggressive pediatric/young adult sarcoma driven by the SS18-SSX fusion oncogene. SS18-SSX has emerged as a multi-faceted disruptor of...