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20,252 grants found
Showing 3,101 – 3,120 of 20,252 grants
Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
Abstract In women, breast cancer is the most commonly diagnosed cancer and leading cause of cancer related deaths worldwide, with approximately 2.3 million new cases and 685,000 de...
Local Tumoral Delivered Immune Checkpoint Blockades Immunotherapy and Radioembolization Combination Therapy
PROJECT SUMMARY Systemic mono- or combination- immune checkpoint blockade (ICB) immunotherapy has been an established therapeutic paradigm. However, a risk of serious autoimmune si...
Prospective international phase-III study to improve neurocognitive outcomes in young children with low-risk medulloblastoma (YCMB-LR)
PROJECT SUMMARY / ABSTRACT Cancer is the second most frequent cause of death in children under 15-years of age, and primary central nervous system (CNS) tumors are the most frequen...
NCI-sponsored Clinical Trial Research Specialist
ABSTRACT NCI-sponsored clinical trials represent some of the highest priority clinical trials conducted by the UF Health Cancer Center (UFHCC). These trials include participation b...
Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary gland
Abstract/Project Summary The goal of this proposal is to understand how transitions through pregnancy influence the molecular and cellular state of mammary epithelial cells and onc...
Investigating facilitator-driven, multi-level implementation strategies in Federally Qualified Health Centers to improve provider recommendation and HPV vaccination rates among Latino/a adolescents
Project Summary/Abstract Approximately 46,143 new cases of human papillomavirus (HPV) associated cancers occur annually in the U.S and there are substantial racial, ethnic, socioec...
Differential Wnt Dependencies in Colon Epithelium.
Project Summary/Abstract This proposal details a five-year training plan for the development of a research program focused on elucidating the therapeutic potential of superimposed...
Investigating CD4+ T cell memory in cancer immunotherapy
Project Summary/Abstract This proposal encompasses a 5-year research and training plan to support the transition of Dr. Wattenberg to an independent research career. Dr. Wattenberg...
Inferring Kinase Activity from Tumor Phosphoproteomic Data
Project Summary Kinases are fundamentally important enzymes for regulating cell physiology through regulation of proteins and protein interactions by phosphorylating tyrosine, seri...
Transcriptome and spatial analyses of tumor environment in addressing colorectal cancer racial and ethnical disparities
PROJECT ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer-related death in the US, with pronounced disparities in mortality by race and ethnicity. Disparities a...
Dissecting the tumor cell-immune TME axis to identify therapeutically actionable vulnerabilities that potentiate immunotherapy in GBM
Glioblastoma multiforme (GBM) is a common and highly aggressive form of brain cancer in adults with a dismal prognosis and limited therapeutic options. A critical component of GBM...
Identifying Inflammatory Mediators of Clonal Hematopoiesis
PROJECT SUMMARY/ABSTRACT Clonal hematopoiesis (CH) is a common phenomenon defined as the presence of somatic mutations in hematopoietic stem and progenitor cells (HSPCs) and their...
Defining the role of chromosomal break end synapsis factors for DNA repair
SUMMARY. Clastogenic cancer therapeutics, i.e., agents that induce chromosomal DNA double-strand breaks (DSBs), such as radiotherapy, remain a cornerstone of cancer treatment. A ce...
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
PROJECT SUMMARY/ABSTRACT Curative cancer treatment modalities (e.g., chemotherapy) are gonadotoxic (i.e., destroy sperm and eggs) and frequently cause infertility. Thus, clinical p...
Understanding metabolic and vascular vulnerabilities of residual disease in triple negative breast cancer to inform on treatment strategies
PROJECT SUMMARY/ABSTRACT Recurrence of cancer cells that evade therapy is a leading cause of death. Given that residual disease can persist for years to decades following therapy,...
Impact of neurofibromin on ER-alpha and nuclear speck post-transcriptional gene regulation
PROJECT SUMMARY Alternative splicing (AS) of transcripts is an essential post-transcriptional process that is instrumental for numerous cell functions including proliferation, diff...
Elucidating the role of mRNA m6A methylation in tumorigenesis
PROJECT SUMMARY/ABSTRACT The current lack of effective, targeted cancer therapies reflects a gap in knowledge surrounding the mechanisms that promote tumorigenesis and emphasizes t...
Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer
Project Summary Pancreatic ductal adenocarcinoma (PDAC) has a median 5-year survival of only 11%, and early diagnosis of PDAC is recognized as one of the highest priority areas by...
Discerning mechanisms of semaphorin 7A-mediated tumor progression via immunoevasion
Project We Summary/Abstract have identified that semaphorin 7a (SEMA7A)—a signaling molecule that activates integrin-β1 signaling in cancer—is upregulated in postpartum breast canc...
Multi-omics for obesity-associated liver disease discovery in Hispanics/Latinos: the Cameron County Hispanic Cohort
ABSTRACT We submit “Multi-omics for obesity-associated liver disease discovery in Hispanics/Latinos: the Cameron County Hispanic Cohort” (hereafter CCHC-Liver) in response to RFA-H...