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20,252 grants found
Showing 3,081 – 3,100 of 20,252 grants
Efficacy and Mechanisms of Resistance to Neoadjuvant Intensive Androgen Signaling Inhibition
PROJECT SUMMARY – PROJECT 1 Localized high-risk prostate cancer (PCa) comprises ~15% of newly diagnosed localized PCa, and the cure rate for these tumors after primary surgical tre...
Molecular Determinants of Response and Resistance to EZH2 and PARP inhibition in Prostate Cancer
PROJECT SUMMARY- PROJECT 2 Castration resistant prostate cancer (CRPC) is a lethal disease. Epigenetic dysregulation, including overexpression of the enhancer of zeste homolog 2 (E...
Dissecting and Predicting Lethal Prostate Cancer using Biologically Informed Artificial Intelligence
PROJECT SUMMARY – PROJECT THREE Treatment strategies for intermediate and high-risk localized prostate cancer (PCa) include surgery or radiation with or without hormonal therapy. M...
Biostatistics/Computational Core
PROJECT SUMMARY – BIOSTATISTICS AND COMPUTATIONAL CORE (CORE B) The Biostatistics and Computational Core (Core B) of the Dana-Farber/Harvard Cancer Center (DF/HCC) Prostate SPORE i...
Biospecimen Core
PROJECT SUMMARY – BIOSPECIMEN CORE (CORE C) Acquisition and characterization of biospecimens linked with clinical data and the development of patient relevant preclinical models,...
Developmental Research Program
PROJECT SUMMARY– DEVELOPMENTAL RESEARCH PROGRAM (DRP) The objective of the SPORE Developmental Research Program (DRP) is to identify and support exciting prostate cancer research a...
Career Enhancement Program
PROJECT SUMMARY – CAREER ENHANCEMENT PROGRAM (CEP) The goal of the DF/HCC Prostate SPORE Career Enhancement Program (CEP) is to provide resources, financial support, and mentorship...
Innovative Rapid Enabling, Affordable, point-of-Care HPV Self-Testing Strategy (I-REACH)
Abstract Each day, there are an estimated 28 cervical cancer deaths in Nigeria, making cervical cancer the second most common cancer among women in the entire country. Only a minor...
Novel circulating biomarker digital scores for assessing treatment response in liver cancer
PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Local ablation and transarterial chemoembolization (TACE) a...
Multiscale modeling of spatiotemporal evolution in Barrett's esophagus
PROJECT SUMMARY The practical goal of this project is to obtain high-resolution genetic and epigenetic maps that reveal the evolutionary relationships and dynamics over space and t...
Washington University (WU) ROBIN Center: MicroEnvironment and Tumor Effects Of Radiotherapy (METEOR)
Project Summary In addition to direct killing of rapidly proliferating tumor cells, radiation therapy (RT) modifies tumor immunity. RT increases the expression and release of tumor...
METEOR Administrative Core
ADMINISTRATIVE CORE SUMMARY Critical to the success of the Washington University (WU) ROBIN “MicroEnvironment Tumor Effects Of Radiotherapy” (METEOR) Center is a structured approac...
METEOR-Comprehensive Radiobiology Assessment TRial (METEOR-CRATR)
MOLECULAR CHARACTERIZATION TRIAL SUMMARY The standard of care (SOC) for locally advanced cervical cancer, pelvic radiation (RT) with concurrent cisplatin, is associated with a 30-5...
Research Project Cervical Cancer
PROJECT 1 SUMMARY (CERVIX) The standard of care (SOC) for locally advanced cervical cancer, pelvic radiation (RT) with concurrent cisplatin, is associated with a 30-50% failure rat...
Research Project Pancreatic Cancer
PROJECT 2 (PANCREAS) SUMMARY The prognosis for pancreatic ductal adenocarcinomas (PDAC) patients is dismal. Unfortunately, attempts at immunotherapy for PDAC to date have not achie...
METEOR-BioLogical Specimen Translation (METEOR-BLST)
The BioLogical Specimen Translation (BLST) Shared Resource of the METEOR ROBIN Center was designed in concert with the leaders of both Projects, the METEORITE cross straining core...
METEOR-Data Synthesis and Transfer (METEOR-DST)
METEOR-DST SUMMARY The METEOR Data Synthesis and Transfer (DST) shared resource provides expertise and systems for synthesizing data from across all data sources in METEOR and enab...
METEOR-Integrated Training Environment (METEORITE)
Project Summary Through existing advances in the field of radiation oncology, it has become clear that success is best achieved when experts in biology, physics, and clinical medic...
Refer 2 Quit: Proactive Promotion of Tobacco Use Treatment for Underserved Household Members Who Smoke through Pediatric Primary Care
Project Summary/Abstract Racial and ethnic minority groups and those from low socioeconomic groups suffer disproportionately from the effects of tobacco marketing, have less access...
The Meharry Cancer Summer Research Program (SuRP)
PROJECT SUMMARY/ABSTRACT Meharry Medical College seeks funding to support the continuation and expansion of the Meharry Cancer Summer Research Program (SuRP), a research experience...