Browse All Grants
20,252 grants found
Showing 3,061 – 3,080 of 20,252 grants
Elucidation of the molecular mechanisms of the RBM15-MKL1 fusion protein in acute megakaryoblastic leukemia
PROJECT SUMMARY/ABSTRACT Acute megakaryoblastic leukemia (AMKL) is a form of cancer most prevalent in children under four years old. Targeted AMKL-specific treatment options are li...
Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)
There are currently over 1.2 million people in Zambia and 1.7 million in Tanzania who are living with HIV/AIDS. Concomitant to the HIV epidemic, there is a high incidence of HIV/AI...
Admin Core
A multi-institutional, international, and integrated endeavor, the “KS in the Era of ART in Africa Program (KEAAP)” will leverage the research and training expertise of collaborati...
Project 1
Despite more than a decade of implementing universal access to antiretroviral therapy (ART) in sub-Saharan Africa (SSA), Kaposi’s sarcoma (KS) remains the most common malignancy in...
Project 2
HIV-associated Kaposi sarcoma (KS), also known as epidemic Kaposi sarcoma (EpKS), is a leading malignancy in sub-Saharan Africa (SSA). It is among the top 10 malignancies by incide...
Project 3
ABSTRACT Kaposi sarcoma (KS), an HIV/AIDS-associated malignancy, is one of the most prevalent cancers in people living with HIV-1 (PLWH) in sub-Saharan Africa (SSA). AIDS-associate...
Data Core
ABSTRACT The Data Management and Integration Core (DMIC) of the Kaposi Sarcoma (KS) in Era of Antiretroviral Therapy in Africa Program (KEAAP) is responsible for streamlining and c...
Developmental Core
ABSTRACT Human resource capacity building and training are urgently needed to establish a sustainable research enterprise that will improve prevention, diagnosis, connection to car...
Deciphering the functional role of recurrent PPP2R1A mutations on endometrial metastasis
Project Summary: Uterine serous carcinomas (USC), uterine carcinosarcomas (UCS), and leiomyosarcomas represent the most aggressive subtypes of uterine cancer and account for a disp...
Molecular mechanism of membrane association of Bruton's Tyrosine Kinase
PROJECT SUMMARY The adaptive immune system is driven by the B Cell receptor (BCR) pathway, which triggers B cell differentiation and proliferation in response to antigen binding. A...
Structural studies of metazoan origin licensing
Project Summary Developing effective cancer therapies remains a significant challenge due to the heterogeneity of tumor physiology, cytotoxicity towards non-cancer cells, and the e...
The role of the gut microbiome in ICB-induced anti-tumor response and toxicity
PROJECT SUMMARY Immune checkpoint blockade (ICB) has transformed clinical oncology by inducing durable responses and increasing survival rates in many types of cancers, including m...
Investigating splicing-derived antigens in the context of Rbm10-mutant lung adenocarcinoma
Project summary: The adaptive immune system can specifically recognize and kill cancer cells. Therapies that reinvigorate tumor-specific CD8 T cells cure a subset of patients with...
Defining the role of persistent DNA bridges in tumor-intrinsic immune activation in hereditary breast and ovarian cancer
PROJECT SUMMARY Chromosome segregation errors such as persistent DNA bridges accelerate genome instability, a hallmark of cancer. These toxic DNA lesions occur at a higher frequenc...
Text-messaging Communication Micro-Intervention for Couples Coping with Advanced GI Cancer
A cancer diagnosis requires patients and their intimate partners to communicate effectively to navigate illness- related challenges. Research indicates that couples who use effecti...
Dissecting Early Tumor Evolution to Uncover Mechanisms of Tumor Initiation and Drug Resistance
PROJECT SUMMARY/ABSTRACT Despite the prevalence of prostate cancer worldwide, we lack an understanding of the genetic events that drive tumor initiation or drug resistance. Only a...
Targeting pancreatic cancer's metabolic addiction to HuR
Pancreatic ductal adenocarcinoma (PDA) is the 3rd leading cause of cancer death in the U.S. and is generally refractory to chemotherapy. We discovered that the harsh PDA microenvir...
Generating Research Opportunities Within Statistics at Fred Hutch (GROWS@FredHutch)
Project Summary/Abstract In cancer research, the need for a diverse pool of researchers in statistics and data science has never been greater. Yet, the requisite academic pipeline...
DF/HCC Prostate SPORE
PROJECT SUMMARY – OVERALL The Dana-Farber/Harvard Cancer Center (DF/HCC) Prostate SPORE seeks to improve the understanding and treatment of prostate cancer using a highly translati...
DF/HCC Prostate SPORE
PROJECT SUMMARY – ADMINISTRATIVE CORE (CORE A) The DF/HCC Prostate SPORE Administrative Core (Core A) is instrumental for the overall function and success of the Prostate SPORE pro...