Browse All Grants
20,252 grants found
Showing 3,041 – 3,060 of 20,252 grants
Impact of TNF on Oncolytic Virotherapy
Project Summary: Oncolytic virotherapy (OV) represents a novel method to treat a variety of solid tumors by inducing anti-tumor immune responses. While this therapy has been extrem...
Next generation T cell therapies for mutant KRAS solid tumors
Project Summary This proposal “Next generation T cell therapies for KRAS mutated solid tumors” was developed in response to RFA-CA-22-028 and to fulfill the Cancer Adoptive Cellula...
Immunoglobulin Replacement Therapy and Infectious Complications After CD19-Targeted CAR-T-Cell Therapy
PROJECT SUMMARY/ABSTRACT Chimeric antigen receptor T cell therapy (CARTx) has transformed treatment for B cell malignancies. However, the effects of CARTx on humoral immunity and i...
The impact of cannabis and tobacco/nicotine product co-use in young adults: Prospective cessation evaluation and substitution
PROJECT SUMMARY/ABSTRACT The co-use of nicotine/tobacco products and cannabis among young adults is prevalent and varies widely in terms of patterns and products of use. Nicotine-c...
Mechanism of double-negative T cells in antitumor immunity to breast cancer
Abstract: Breast cancer (BC), the most common cancer globally as of 2021 and accounting for 12% of all new annual cancer cases worldwide, is the most commonly diagnosed cancer amon...
Quantitation of nutrient metabolism in brain tumor patients using advanced 13C isotopomer technology
Project Summary/Abstract Malignant brain tumors are aggressive cancers that have high proliferative rates with much higher energy requirements and high mortality rates. Despite int...
Epigenetic dependence of diffuse midline glioma with H3K27M mutation
Diffuse intrinsic pontine glioma (DIPG) is a deadly disease with the median survival of DIPG patients less than one year after diagnosis. DIPG tumors initiate from the pons and mid...
Social Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and Aging
By 2030, three-quarters of the 22 million US cancer survivors will be 65 and older and the number of older Hispanic and Black survivors will have grown three times faster than Whit...
MYCN drives a ferroptotic vulnerability in neuroblastoma
Project Summary: Apoptosis is a type of programmed cell death and has for a long time been appreciated to be a hallmark of cancer cells. In recent years, drugs targeting the apopto...
Multidomain Peptide Hydrogels as a Therapeutic Delivery Platform for Cancer Treatment
ABSTRACT In the United States, cancer is the second leading cause of death, and it is projected that 39.5% of all US adults will be diagnosed with cancer in their lifetimes. Carcin...
Inter-organellar communication in metabolic reprogramming of colorectal cancer
PROJECT SUMMARY Colorectal cancers (CRC) are characterized as having a hierarchical organization requiring proliferating and de-differentiated stem cells to maintain tumor growth a...
Interrogating the Fgl2-FcgRIIB axis: A novel mechanism mediating apoptosis of tumor-specific memory CD8+ T cells
PROJECT SUMMARY One in fifty Americans will be diagnosed with melanoma in their lifetime and skin cutaneous melanoma is the deadliest skin cancer. Cancer immunotherapy is a breakth...
Cancer Prevention-Interception Against MGUS Progression
Project Summary Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition in which a person has moderately elevated levels of an abnormal immunoglobulin...
Administrative Core
Project Summary The Administrative Core at the Cancer Prevention-Interception against MGUS Progression (CAP-MGUS) Center will provide administrative, scientific, fiscal, and logist...
GARDE: Scalable Clinical Decision Support for Individualized Cancer Risk Management
PROJECT SUMMARY/ABSTRACT Evidence supports individualizing risk-stratified cancer screening, with selective application of specific screening interventions best suited to the indiv...
Programmable peptide-guided protein degradation
Summary Over 600 human proteins have been recently prioritized as key cancer targets, with nearly half being considered ‘intractable’ by standard small-molecule inhibition approach...
Understanding initiation and progression of IPMNs in pancreatic cancer
Project Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal survival rate at just 10%, largely because most patients are diagnosed after the cancer h...
Deep Sequencing of Relapse and Refractory Hodgkin Lymphoma Genomes: A Study of Tumor Biology and Evolution
Hodgkin lymphoma (HL) accounts for ten percent of all lymphomas in the western world and remains a substantial clinical problem. Relapsed and refractory (R/R) HL presents a particu...
University of California, Davis: Human Papillomavirus Cancer Free (UCD: HPV Cancer Free)
This K01 award resubmission outlines an intensive five-year research career development program focused on multilevel behavioral intervention and dissemination and implementation s...
Prevalence and persistence of the ETV6/RUNX1 pre-leukemic clone
Abstract Leukemia is the most common childhood cancer and represents approximately one third of all cancer diagnoses among children age 0-14. There is strong evidence that acute ly...